Borderline sebaceous neoplasm in a renal transplant patient without Muir‐Torre syndrome

Kaminska, Edidiong Celestine Ntuen; Iyengar, Vivek; Tsoukas, Maria M.; Shea, Christopher R.

doi:10.1111/cup.12046

Cited by 16 publications

(16 citation statements)

References 17 publications

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“…8,9 The case of a borderline sebaceous neoplasm in a renal transplant patient without MTS, founding an aberrant loss of MLH-1 expression in the sebaceous neoplasm and intact MSH-2 expression, recently has been reported. 10 However, we did not find any pathologic mutations in MLH1 and MSH2, but we did in MSH6-eson1 (c116G>A). However, MSH6-eson1 mutation (present in 10% to 20% of Lynch syndrome) can be ascribed to a polymorphism rather than a pathologic mutation linked to MTS.…”

Section: Discussioncontrasting

confidence: 62%

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Donati

Paolino

Muscardin

et al. 2017

Exp Clin Transplant

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Nonmelanoma skin cancers are the most common malignancies in transplant recipients under immunosuppression; nevertheless, appendage tumors also may appear. The onset of several cutaneous neoplasms in transplant patients can cause deterioration in quality of life of these patients.A 62-year-old white woman patient developed several malignant and benign sebaceous neoplasms during an immunosuppressive treatment for a renal transplant. The genetic study showed a mutation in MSH6-eson 1 (c116G>A), without mutations in MLH1 gene and MSH2. A final diagnosis of multiple sebaceous tumors in an immunosuppressed patient without Muir-Torre syndrome was made. The spreading of further cutaneous neoplasms led to a change in immunosuppression: namely, that clinicians suspended tacrolimus and add everolimus. After 2 months, all tumor lesions on the face and on the limbs have disappeared, and no further lesions occurred.Everolimus could represent a valid therapeutical treatment for transplant patients at high risk for cutaneous tumors. A genetic consult and a consequent study of the genetic profile should be performed on each of these patients, to avoid risks of recurrent cutaneous tumors and negative effects on the quality of life.

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Section: Discussioncontrasting

confidence: 62%

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Donati

Paolino

Muscardin

et al. 2017

Exp Clin Transplant

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“…Some authors use this term for lesions identical to sebaceoma that they consider to be benign sebaceous neoplasms with predominant proliferation of immature cells . Kaminska et al . reported a similar neoplasm in a renal transplant patient without Muir–Torre syndrome, and designated it as a borderline sebaceous neoplasm (BSN).…”

Section: Sebaceous Neoplasmsmentioning

confidence: 99%

Topics in histopathology of sweat gland and sebaceous neoplasms

Ansai

2017

The Journal of Dermatology

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This article reviews several topics regarding sweat gland and sebaceous neoplasms. First, the clinicopathological characteristics of poroid neoplasms are summarized. It was recently reported that one-fourth of poroid neoplasms are composite tumors and one-fourth are apocrine type lesions. Recent progress in the immunohistochemical diagnosis of sweat gland neoplasms is also reviewed. CD117 can help to distinguish sweat gland or sebaceous tumors from other non-Merkel cell epithelial tumors of the skin. For immunohistochemical differential diagnosis between sweat gland carcinoma (SGC) other than primary cutanesous apocrine carcinoma and skin metastasis of breast carcinoma (SMBC), a panel of antibodies may be useful, including p63 (SGC + , SMBC ). Comparison of antibodies used for immunohistochemical diagnosis of sebaceous carcinoma (SC) suggests that adipophilin has the highest sensitivity and specificity. Some authors have found that immunostaining for survivin, androgen receptor and ZEB2/ SIP1 has prognostic value for ocular SC, but not extraocular SC. In situ SC is rare, especially extraocular SC, but there have been several recent reports that actinic keratosis and Bowen's disease are the source of invasive SC. Finally, based on recent reports, classification of sebaceous neoplasms into three categories is proposed, which are sebaceoma (a benign neoplasm with well-defined architecture and no atypia), borderline sebaceous neoplasm (low-grade SC; an intermediate tumor with well-defined architecture and nuclear atypia) and SC (a malignant tumor with invasive growth and evident nuclear atypia).

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“…Furthermore, sebaceous carcinoma is commonly associated with a genetic predisposition for MTS, an autosomal dominant hereditary disease characterized by the association of a skin tumor of sebaceous lineage, with or without a keratoacanthoma associated with one or more visceral neoplasms3,5. Several cases have been reported after kidney transplantation and immunosuppression6,7.…”

Section: Discussionmentioning

confidence: 99%

“…An association between microsatellite instability and sebaceous carcinoma in immunosuppressed patients who underwent organ transplantation and who do not have MTS has been suggested11. Kaminska et al7 reported a case of sebaceous carcinoma mixed with sebaceous adenoma after kidney transplantation, suggesting the possibility of a sebaceous adenoma-sebaceous carcinoma neoplastic sequence. The present patient also had a specimen consisting mostly of well-differentiated sebaceous gland-forming sebocytes, with a focal region of infiltrative growth, mitotic figures, pleomorphic nuclei, and atypia, all of which may implicate a similar pathological sequence.…”

Section: Discussionmentioning

confidence: 99%

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Sebaceous Carcinoma of the Suprapubic Area in a Liver Transplant Recipient

et al. 2014

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Sebaceous carcinoma is a very rare and potentially aggressive carcinoma originating from the epithelial lining of the sebaceous gland. More than 70% of all cases are in the head and neck region, especially the periorbita; therefore, they are classified into ocular and extraocular sebaceous carcinoma. The reported risk factors are advanced age, male sex, previous irradiation, and genetic predisposition for Muir-Torre syndrome. The current case is of sebaceous carcinoma found in the suprapubic area of a 67-year-old male patient who had received liver transplantation 6 years before, and had been receiving oral tacrolimus. Examination of the gastrointestinal system did not reveal any other malignancies. Although nonmelanoma skin cancers may occur as a complication after liver transplantation, there have been no previous reports of sebaceous carcinoma after liver transplantation. Furthermore, the sebaceous carcinoma in this case occurred in an uncommon location. We report this case along with a review of the literature.

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Borderline sebaceous neoplasm in a renal transplant patient without Muir‐Torre syndrome

Cited by 16 publications

References 17 publications

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Topics in histopathology of sweat gland and sebaceous neoplasms

Sebaceous Carcinoma of the Suprapubic Area in a Liver Transplant Recipient

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