This thematic literature review explores the contribution of family/systemic approaches in the treatment and care of people with borderline personality disorder (BPD) in acute adult mental health care settings. It recognises the importance of early childhood trauma, family dynamics, and relationships in the aetiology of BPD and outlines key benefits and constraints of a family systems approach. The article discusses institutional, cultural, and power structures that influence the diagnosis and treatment process for adult clients with BPD and the value of relational ethics in guiding or mediating care between the family, healthcare system, and community.1 This thematic literature review examines family systemic therapy for adults with a diagnosis of borderline personality disorder (BPD). 2 Diagnosis and treatment may contribute to positive and negative experiences associated with stigma and power differentials in and between the family, healthcare system, and community. 3 Power structures in medical and family systems influence the treatment process for BPD. 4 Family systemic approaches and relational ethics are useful guiding frameworks in shaping and mediating treatment, care, and decision making. 5 There are benefits and constraints in using family systemic approaches in the treatment of BPD in acute adult mental health care settings.