Borderline personality disorder in major depression: Symptomatology, temperament, character, differential drug response, and 6-month outcome

Joyce, Peter R.; Mulder, Roger; Luty, Suzanne E.; McKenzie, Janice M.; Sullivan, Patrick F.; Cloninger, Robert

doi:10.1053/comp.2003.50001

Cited by 119 publications

(85 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Adult patients with attempted suicide scored higher in the temperamental dimension 'harm avoidance' and lower in the character dimensions 'self-directedness' and 'cooperativeness' [59] when compared to normal controls. Studies in adult patients with depression [64,65] , previous suicide attempts [66] and BPD [42] found associations between SIB and 'harm avoidance' or 'novelty seeking'. This was not confirmed in our patients.…”

Section: Discussionmentioning

confidence: 99%

Self-Injurious Behavior in Adolescent Girls

et al. 2008

View full text Add to dashboard Cite

Background: Self-injurious behavior (SIB) is increasingly popular in psychically ill adolescents, especially in girls with posttraumatic stress (PTSD) and personality disorders. Adolescents with SIB frequently exhibit neurofunctional and psychopathological deficits. We speculated that specific neuropsychological deficits and temperamental factors could predispose patients to SIB and prospectively explored adolescent psychiatric patients with and without SIB in order to find out differences in psychopathology, and neuropsychological or temperamental factors. Sampling and Methods: Ninety-nine psychically ill adolescent girls with SIB, aged 12–19 years and treated at our clinic, were prospectively recruited during a period of 5.5 years (1999–2005). The clinical (ICD-10) diagnoses were mainly substance abuse, eating disorders, depression, PTSD and personality disorders. The control group was also prospectively recruited during the same period and consisted of 77 girls with similar diagnoses and ages but no SIB. All patients were subjected to the same selection of clinical and neuropsychological tests, mainly self-rating questionnaires and tests evaluating executive functions. Results: Adolescent girls with psychiatric disease and SIB were more severely traumatized and depressed. They reported severe emotional and behavioral problems and deficits of self-regulation. In addition, their parents more frequently had psychiatric problems. Temperament, intelligence, investigated executive functions and presence of dissociative symptoms were not different in patients with and without SIB. Conclusions: We could not verify our primary hypothesis that SIB is related to specific neuropsychological deficits or temperamental factors. SIB was associated with traumatic experience, depression, problems of self-regulation and parental psychiatric disease. The prevention of SIB should therefore focus on improving affect regulation, the management of emotional distress and problem-solving strategies.

show abstract

Section: Discussionmentioning

confidence: 99%

Self-Injurious Behavior in Adolescent Girls

et al. 2008

View full text Add to dashboard Cite

show abstract

“…A negative impact on self-esteem was noted from the discriminatory behaviour; this is an unsurprising result as negative ideas about the self may be especially available to those diagnosed with BPD (Joyce et al 2003). Due to the availability of these negative ideas, clients with a BPD diagnosis might be viewed as particularly vulnerable to perceived discrimination due to the likelihood that any stigma from professionals may be interpreted as legitimate (Corrigan & Watson 2002).…”

Section: S Veyseymentioning

confidence: 99%

People with a borderline personality disorder diagnosis describe discriminatory experiences

Veysey

2014

Kōtuitui: New Zealand Journal of Social Sciences Online

View full text Add to dashboard Cite

The psychiatric diagnosis of borderline personality disorder (BPD) attracts considerable stigma. People given this diagnosis may be characterised as manipulative, difficult, attention-seeking or untreatable. This paper describes a New Zealand study where eight people with a BPD diagnosis who selfidentified as encountering discriminatory experiences from healthcare professionals were interviewed. Themes found included that discriminatory experiences contributed to participants' negative selfimage and negative messages about the BPD label were communicated. A self-harm history appeared to be related to an increased number of discriminatory experiences. Connecting with the person and 'seeing more' (beyond an individual's diagnosis and/or behaviour) epitomised helpful experiences. Additionally, a relationship between stigma and the complaints process was noted. This study privileges the voice of those interviewed and may stimulate thought and discussion for services and health professionals working with this group.

show abstract

“…It is a very common phenomenon 33 and a recent meta-analysis reported that it has been considered a possible clinical negative predictor of response to treatment, 34 consistently with early studies [35][36][37][38] whereas others reported a similar outcome for people with and without personality disorders comorbidity using only well-designed study 39 consistent with some recent studies. [40][41][42] Apart from specific personality disorders, also temperament traits have been associated with response, generally in the direction of a poorer response in subjects with high harm avoidance. 43,44 The influence of genes on personality is debated as well, though some studies reported the associations of personality disorders with genetic polymorphism, particularly DRD4 and 5-HTTLPR, 45 also in depressed patients 46 these remain still controversial.…”

Section: Clinical Features Of Comorbid Disorders: Axis IImentioning

confidence: 99%

Pharmacogenetic studies in depression: a proposal for methodologic guidelines

2007

View full text Add to dashboard Cite

Pharmacogenetic studies in mood disorders are rapidly proliferating after the initial reports linking gene variants to treatment outcomes. However, a considerable range of methodologies has been used, making it difficult to compare results across studies and limiting the representativeness of findings. Specification of sampling source (inpatients vs outpatients, primary vs tertiary settings), standardization of diagnostic systems and treatments, adequate monitoring of compliance through plasma levels, sufficient length of observation (at least 6 weeks for acute antidepressant treatments, though 3-6 months are preferable), the use of a range of response criteria and the inclusion of possible environmental confounding variables (life events, social support, temperament) are all potentially important issues when planning pharmacogenetic studies. We reviewed the state-of-the-art methodology and suggested possible guideline for future studies.

show abstract

Borderline personality disorder in major depression: Symptomatology, temperament, character, differential drug response, and 6-month outcome

Cited by 119 publications

References 20 publications

Self-Injurious Behavior in Adolescent Girls

Self-Injurious Behavior in Adolescent Girls

People with a borderline personality disorder diagnosis describe discriminatory experiences

Pharmacogenetic studies in depression: a proposal for methodologic guidelines

Contact Info

Product

Resources

About