Borderline personality disorder and substance use disorders A review and integration

Personality Disorders and the 3-Year Course of Alcohol, Drug, and Nicotine Use Disorders

“…When studied, this personality disorder is also associated with substance use disorders in clinical 33, 80 and general population samples 29, 79 . Using structural modeling techniques, we recently showed that borderline personality disorder is located on both the internalizing and externalizing domains of psychopathology 79 .…”

Borderline Personality Traits and Substance Use: Genetic Factors Underlie the Association with Smoking and Ever Use of Cannabis, but Not with High Alcohol Consumption

“…The personality traits affective instability (i.e., emotional dysregulation) and impulsivity are associated with both BPD and SUD and therefore proposed to reflect the genetic liability to develop both BPD and SUD (Bornovalova, Lejuez, Daughters, Rosenthal, & Lynch, 2005;Sher & Trull, 2002;Trull et al, 2000). First, regarding affective instability, several studies suggest that substance use may serve to decrease feelings of negative affect or increase feelings of positive affect (Baker, Brandon, & Chassin, 2004;Baker, Piper, McCarthy, Majeskie, & Fiore, 2004;Jahng, Solhan et al, 2011;Trull et al, 2000).…”

“…The presentation of borderline personality disorder (BPD) with a comorbid substance use disorder (SUD) is common in clinical and population samples (Feske, Tarter, Kirisci, & Pilkonis, 2006;Tomko, Trull, Wood, & Sher, in press;Trull, Sher, Minks-Brown, Durbin, & Burr, 2000;Trull, Jahng, Tomko, Wood, & Sher, 2010). Also, higher rates of alcohol and drug abuse and dependence and a higher rate of new onsets of SUD are found in patients with BPD than in patients with other personality disorders (McGlashan et al, 2000;Walter et al, 2009;Zanarini et al, 2011).…”

“…Also, higher rates of alcohol and drug abuse and dependence and a higher rate of new onsets of SUD are found in patients with BPD than in patients with other personality disorders (McGlashan et al, 2000;Walter et al, 2009;Zanarini et al, 2011). In a comprehensive review, Trull et al (2000) report that almost 60% of the individuals diagnosed with BPD meets criteria for a general category of substance use disorder, almost 50% meets criteria for an alcohol use disorder (abuse or dependence) and almost 40% meets criteria for a drug use disorder (abuse or dependence). The co-occurrence of BPD and SUD is associated with an increased risk for suicide attempts, poorer school performance, a higher level of unemployment, more promiscuity, and more early termination from treatment (Karterud, Arefjord, Andresen, & Pedersen, 2009;Miller, Abrams, Dulit, & Fyer, 1993;van den Bosch, Verheul, & van den Brink, 2001).…”

Childhood trauma and functional disability in psychosis, bipolar disorder and borderline personality disorder: a review of the literature

“…Volumetric reductions in the amygdala (Soloff et al 2008;Aas et al 2012a;Hoy et al 2012), hippocampus (Hoy et al 2012), ventrolateral prefrontal cortex (Morandotti et al 2013) and in total grey matter (Sheffield et al 2013) have been reported among patients with psychotic disorders and borderline personality disorder with a history of childhood trauma compared with those without such a history. Structural brain changes as a result of childhood maltreatment have been associated with the severity of substance use relapse (Van Dam et al 2014), which may represent a significant problem given the high rates of such disorders reported among psychosis and borderline personality disorder cohorts (Regier et al 1990;Trull et al 2000). There is also evidence that childhood trauma may increase stress sensitivity among patients with psychosis, potentially through alterations in functioning of the hypothalamicpituitary-adrenal axis, the body's neurobiological stress response system (Neigh et al 2009;Lardinois et al 2011).…”