Borderline personality disorder and rTMS: A pilot trial

Cailhol, Lionel; Roussignol, Bruno; Klein, Richard; Bousquet, Benjamin; Simonetta‐Moreau, Marion; Schmitt, Laurent; Thalamas, Claire; Tap, Gérard; Birmes, Philippe

doi:10.1016/j.psychres.2014.01.030

Cited by 36 publications

(37 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our preliminary results are similar to those reported previously for clinical areas (anger, affective instability, impulsiveness) with the application of high-frequency rTMS (10 Hz) to the left 17 and right DLPFC. 18,19 Cailhol et al 18 observed improvement in neuropsychological areas (decision-making). While most BPD studies apply fewer sessions with higher excitatory frequencies, earlier works by Reyes et al 20 showed that at lower frequencies (which enhance tolerability with a lower risk of adverse effects), applying rTMS to the left and right DLPFC (5 Hz and 1 Hz, respectively) yielded similar improvement in all clinical domains, as reported by the CGI-BPD and other clinical instruments, like the Beck Depression Inventory (BDI), BIS, HARS, and BEST.…”

Section: Discussionmentioning

confidence: 98%

Improvement in borderline personality disorder symptomatology after repetitive transcranial magnetic stimulation of the dorsomedial prefrontal cortex: preliminary results

Calderón-Moctezuma

Reyes-López

Rodríguez-Valdés

et al. 2021

Braz. J. Psychiatry

View full text Add to dashboard Cite

Objective: Current treatment for borderline personality disorder (BPD) involves psychological and pharmacological interventions. However, neuromodulation techniques such as repetitive transcranial magnetic stimulation (rTMS) may positively affect BPD symptomatology. The objective of this study was to evaluate the clinical and neuropsychological effects of rTMS on the dorsomedial prefrontal cortex (DMPFC) in BPD patients. Methods: Fourteen patients with BPD were randomized into two groups (active vs. sham) for 15 sessions of rTMS on the DMPFC. Clinical effects were measured using the Borderline Symptoms List (BSL), Clinical Global Impression Scale for BPD (CGI-BPD), Borderline Evaluation of Severity over Time (BEST), Hamilton Depression Rating Scale (HDRS), Hamilton Anxiety Rating Scale (HARS), and Barratt's Impulsiveness Scale (BIS). Neuropsychological effects were determined by a Stop-Signal Task (SST), the Wisconsin Card-Sorting Test (WCST), and the Iowa Gambling Test (IGT). Results: Within-group comparison showed significant differences (p o 0.05) in CGI-BPD (total score and six of nine psychopathologic domains), BEST, HDRS, HARS, and IGT scores for active modality. Conclusion: The 5 Hz-DMPFC rTMS technique was well tolerated and lessened the severity of BPD symptomatology, especially abandonment, affective issues, interpersonal relationships, suicidal behavior, anger, and paranoid ideation. Cognitive improvement was seen in decision-making. Additional studies are needed to fully evaluate the effects of rTMS on BPD symptomatology. Clinical Trial Registration: NCT03832777.

show abstract

Section: Discussionmentioning

confidence: 98%

Improvement in borderline personality disorder symptomatology after repetitive transcranial magnetic stimulation of the dorsomedial prefrontal cortex: preliminary results

Calderón-Moctezuma

Reyes-López

Rodríguez-Valdés

et al. 2021

Braz. J. Psychiatry

View full text Add to dashboard Cite

show abstract

“…Further, severe BPD patients have impairment in decision-making functionality ( 67 ). In view of the above findings, Cailhol et al evaluated the advantages of intermittent application of high-frequency transcranial magnetic stimulation (TMS) application on the right cerebral cortex in treating BPD ( 68 ).…”

Section: Treatmentmentioning

confidence: 99%

Patients with Borderline Personality Disorder in Emergency Departments

et al. 2017

View full text Add to dashboard Cite

Borderline personality disorder (BPD) patients, when in crisis, are frequent visitors of emergency departments (EDs). When these patients exhibit symptoms such as aggressiveness, impulsivity, intense anxiety, severe depression, self-harm, and suicidal attempts or gestures, diagnosis, and treatment of the BPD becomes challenging for ED doctors. This review will, therefore, outline advice to physicians and health-care providers who face this challenging patient population in the EDs. Crisis intervention should be the first objective of clinicians when dealing with BPD in the emergency. For the patients with agitation, symptom-specific pharmacotherapy is usually recommended, while for non-agitated patients, short but intensive psychotherapy especially dialectical behavior therapy (DBT) has a positive effect. Although various psychotherapies, either alone or integrated, are preferred modes of treatment for this group of patients, the effects of psychotherapies on BPD outcomes are small to medium. Proper risk management along with developing a positive attitude and empathy toward these patients will help them in normalizing in an emergency setting after which treatment course can be decided.

show abstract

“…After excluding duplicates and nonrelevant contributions (e.g. theoretical articles), five studies were included in the review [70][71][72][73][74].…”

Section: Review Of Rtms Treatment Studies In Bpdmentioning

confidence: 99%

“…Cailhol et al [71] performed a randomized controlled stimulation of 10 BPD patients by HF 10 Hz rTMS over the right DLPFC. Five patients received active stimulation, and five patients received sham stimulation.…”

Section: Review Of Rtms Treatment Studies In Bpdmentioning

confidence: 99%

Repetitive Transcranial Magnetic Stimulation Treating Impulsivity in Borderline Personality Disorder and Attention Deficit/Hyperactivity Disorder

Svěrák¹,

Linhartová²,

Fiala³

et al. 2018

Transcranial Magnetic Stimulation in Neuropsychiatry

View full text Add to dashboard Cite

The need for novel treatment approaches that target impulsivity symptoms in neuropsychiatric disorders is clear. Repetitive transcranial magnetic stimulation (rTMS) allows selective neuromodulation of regions involved in the functional neuroanatomy of neuropsychiatric disorders. This chapter presents impulsivity in psychiatry, especially in borderline personality disorder (BPD) and attention-deficit hyperactivity disorder (ADHD), its neural underpinnings, and its possible treatment by rTMS. We reviewed available studies on rTMS in impulsivity in BPD and ADHD published before August 13, 2017, systematically searching in the PubMed, Web of Science, and Scopus databases. The results are discussed in the context of the latest neuropsychological models of impulsivity and their underlying functional neuroanatomy. rTMS treatment of impulsivity in BPD and ADHD seems to be a plausible approach. The functional neuroanatomy of processes related to impulsive behavior and decision making in these disorders is linked with abnormalities in the fronto-limbic structures that can be targeted and modulated by rTMS. Although limited evidence is available, rTMS seems to be a safe and potentially effective method of impulsivity treatment in patients with BPD and ADHD. However, more studies are needed to determine the most efficient cortical location and design for rTMS treatment of impulsivity.

show abstract

Borderline personality disorder and rTMS: A pilot trial

Cited by 36 publications

References 24 publications

Improvement in borderline personality disorder symptomatology after repetitive transcranial magnetic stimulation of the dorsomedial prefrontal cortex: preliminary results

Improvement in borderline personality disorder symptomatology after repetitive transcranial magnetic stimulation of the dorsomedial prefrontal cortex: preliminary results

Patients with Borderline Personality Disorder in Emergency Departments

Repetitive Transcranial Magnetic Stimulation Treating Impulsivity in Borderline Personality Disorder and Attention Deficit/Hyperactivity Disorder

Contact Info

Product

Resources

About