Borderline Clear Cell Adenofibroma of the Ovary

Kleebkaow, Pilaiwan; Aue-aungkul, Apiwat; Temtanakitpaisan, Amornrat; Kietpeerakool, Chumnan

doi:10.1155/2017/3860107

Cited by 8 publications

(9 citation statements)

References 6 publications

(11 reference statements)

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“…Although endometriosis has been implicated as a precursor for certain types of epithelial ovarian cancer [7,8], the occurrence of ascites secondary to endometriosis is rarely encountered, particularly among Asian women. This entity simulates gynecological malignancy and is seldom recognized before surgical exploration of the abdomen.…”

Section: Discussionmentioning

confidence: 99%

Endometriosis-Associated Massive Ascites in an Asian Woman: A Case Report of a Rare Clinical Entity

Eamudomkarn

Likitdee

Kleebkaow

et al. 2020

Case Reports in Obstetrics and Gynecology

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Massive ascites as a presentation of endometriosis is a rare clinical entity that is most commonly seen in black nulliparous females. Herein, we describe a case of a 32-year-old multiparous Thai woman who presented with a two-year history of abdominal distension. Computerized tomography of the abdominopelvic region showed an infiltrative enhancing lesion involving the cul-de-sac and perirectal region with massive loculated ascites, suggesting carcinomatosis peritonei. Abdominal paracentesis was performed to yield fluid samples for evaluation, which revealed no malignant cells, and polymerase chain reaction (PCR) was negative for tuberculosis. The patient underwent exploratory laparotomy which revealed a large amount of serosanguinous ascites, thickened matted bowel loops, and necrotic debris covering the entire surface of the peritoneum and visceral organs. The surgical procedures included drainage of 6.5 liters of ascites, lysis adhesion, biopsy of the peritoneum, and right salpingo-oophorectomy. Histologic examination revealed benign endometrial glands with stroma at the peritoneum tissue and broad ligament. Other causes of ascites were excluded. The ascites responded to drainage and hormonal suppression. A final diagnosis of endometriosis was made based on these findings. Endometriosis should therefore be considered in differential diagnosis in women of childbearing age who present with ascites.

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Section: Discussionmentioning

confidence: 99%

Endometriosis-Associated Massive Ascites in an Asian Woman: A Case Report of a Rare Clinical Entity

Eamudomkarn

Likitdee

Kleebkaow

et al. 2020

Case Reports in Obstetrics and Gynecology

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“…Thus, CCBT was regarded as deriving from only clear cell adenofibroma in the adenofibromatous pathway. In previous reports, 95.1% of cases with CCBT coexisted fibromatous component (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26). However, in case 1 in our case, CCBT was considered to develop from endometriosis because CCBT was adjacent to atypical endometriosis and endometriosis.…”

Section: Discussionmentioning

confidence: 56%

“…A review of literature of CCBT with and without fibromatous component including our study were demonstrated in Table II (8,(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26). There were 81 cases with CCBT; 77 cases (95.1%) with fibromatous component and 4 cases (4.9%) without fibromatous component.…”

Section: Discussionmentioning

confidence: 78%

Clear cell borderline tumor without fibromatous component: Pathological and literature review and report of two cases

et al. 2021

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The aim of the present study was to examine the clinical outcome of ovarian clear cell borderline tumor (CCBT) through pathological review for cases with clear cell carcinoma (CCC) and CCBT between 1984 and 2015 who received surgery at the National Defense Medical College Hospital using 2020 World Health Organization (WHO) criteria. In addition to the definition of CCBT in 2020 WHO criteria, clear cell with atypia of the glandular epithelium without fibromatous component was added to the diagnostic criteria of CCBT. Two cases with CCBT were identified through review in the current study. There were no cases that changed from the initial CCBT diagnosis that were included in the current study. Case 1 was a 43-year-old woman who received total hysterectomy, bilateral salpingo-oophorectomy and partial omentectomy. Pathologically, cysts were lined by cuboidal, hobnail and clear cells with eosinophilic cytoplasm and moderate nuclear atypia without the fibromatous component. These cells were adjacent to atypical endometriosis and non-atypical endometriosis, and the patient was diagnosed with CCBT. She exhibited no evidence of the disease for 37 months following surgery. Case 2 was a 42-year-old woman who received left salpingo-oophorectomy, partial omentectomy and pelvic lymphadenectomy. The tumor exhibited a cyst (80 mm) and nodular component. Pathologically, the tumor cells were lined by hobnail cells with mild atypia and eosinophilic cytoplasm without the fibromatous component. This patient was diagnosed with CCBT and exhibited no evidence of disease for 20 months following surgery. CCBT without fibromatous component is a rare and non-aggressive histological subtype. Additionally, regardless of fibromatous component, CCBT was able to be diagnosed.

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“…However, in the case series of this review, we failed to find a prevalent fibrosis pattern within the AWE; interestingly, we reported the first case in the literature of BCCT growth on AWE, that support this hypothesis. These types of lesions represent less than 1% of ovarian borderline tumors and little is known about the mechanisms involved in the neoplastic progression of this entity 67 . When occurs, tumor arises from AWE become a challenge for both surgical and medical management.…”

Section: Discussionmentioning

confidence: 99%

Clear cell degeneration associated with endometriosis of abdominal wall after cesarean section: A case report and systematic review of literature

Ferrari

Forte

Ardighieri

et al. 2021

J of Obstet and Gynaecol

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Aim The scar of cesarean section (CS) is the most common site of abdominal wall endometriosis (AWE), whose tumor degeneration has been reported in an increasing number of cases; the most frequent histological type is clear cell carcinoma (CCC). Methods We conducted a systematic research of the literature, collecting data regarding the evidence on tumor degeneration from AWE after CS. Moreover, we reported a case of clear cell borderline tumor (CCBT) originating from AWE. Results We included data of 37 patients with diagnosis of CCC. The average time between the last CS and the diagnosis of CCC was around 15 years. Overall, 26.0% and 73.9% patients received exclusive local abdominal resection of the lesion and additional surgery, respectively. Lymph nodes involvement was detected in 26.0 % patients and adjuvant chemotherapy was administered in 52.0 % cases. During follow‐up period, 15.2% patients died of disease, 32.6% had no evidence of disease, and 17.4% recurred. We diagnosed a CCBT arose in a patients with AWE and a personal history of several surgical procedures for endometriosis, a CS and a subsequent transverse laparotomy. We performed an open bilateral ovariectomy and a large excision of the endometriotic abdominal lesion. Conclusion Tumor degeneration from AWE seems to be a real occurrence with an increasing number of events. Considering the lack of risk factors and diagnostic instruments for tumor degeneration, the removal of AWE localization could be advisable, even though there was long average time between the trigger surgery and the tumor finding.

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Borderline Clear Cell Adenofibroma of the Ovary

Cited by 8 publications

References 6 publications

Endometriosis-Associated Massive Ascites in an Asian Woman: A Case Report of a Rare Clinical Entity

Endometriosis-Associated Massive Ascites in an Asian Woman: A Case Report of a Rare Clinical Entity

Clear cell borderline tumor without fibromatous component: Pathological and literature review and report of two cases

Clear cell degeneration associated with endometriosis of abdominal wall after cesarean section: A case report and systematic review of literature

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