Boosting with updated COVID-19 mRNA vaccines

Bhattacharya, Deepta; Victora, Gabriel D.

doi:10.1038/s41591-022-02048-y

Nat Med

2022

DOI: 10.1038/s41591-022-02048-y

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Boosting with updated COVID-19 mRNA vaccines

Deepta Bhattacharya

Gabriel D. Victora

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2024

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Cited by 3 publications

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One‐Component Cationic Lipids for Systemic mRNA Delivery to Splenic T Cells

Zhang,

Su,

et al. 2024

Angewandte Chemie

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Unlocking the full potential of mRNA immunotherapy necessitates targeted delivery to specific cell subsets in the spleen. Four‐component lipid nanoparticles (LNPs) utilized in numerous clinical trials are primarily limited in hepatocyte and muscular targeting, highlighting the imperative demand for targeted and simplified non‐liver mRNA delivery systems. Herein, we report the rational design of one‐component ionizable cationic lipids to selectively deliver mRNA to the spleen and T cells with high efficacy. Unlike the tertiary amine‐based ionizable lipids involved in LNPs, the proposed cationic lipids rich in secondary amines can efficiently deliver mRNA both in vitro and in vivo as the standalone carriers. Furthermore, these vectors facilitate efficacious mRNA delivery to the T cell subsets following intravenous administration, demonstrating substantial potential for advancing immunotherapy applications. This straightforward strategy extends the utility of lipid family for extrahepatic mRNA delivery, offering new insights into vector development beyond LNPs to further the field of precise mRNA therapy.

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One‐Component Cationic Lipids for Systemic mRNA Delivery to Splenic T Cells

Zhang,

Su,

et al. 2024

Angewandte Chemie

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One‐Component Cationic Lipids for Systemic mRNA Delivery to Splenic T Cells

Zhang,

Su,

et al. 2024

Angew Chem Int Ed

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A novel multitargeted self-assembling peptide-siRNA complex for simultaneous inhibition of SARS-CoV-2-host cell interaction and replication

Tuttolomondo,

Pham,

Terp

et al. 2024

Molecular Therapy - Nucleic Acids

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Boosting with updated COVID-19 mRNA vaccines

Cited by 3 publications

References 11 publications

One‐Component Cationic Lipids for Systemic mRNA Delivery to Splenic T Cells

One‐Component Cationic Lipids for Systemic mRNA Delivery to Splenic T Cells

One‐Component Cationic Lipids for Systemic mRNA Delivery to Splenic T Cells

A novel multitargeted self-assembling peptide-siRNA complex for simultaneous inhibition of SARS-CoV-2-host cell interaction and replication

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