Boosting of retinol activity using novel lecithin: Retinol acyltransferase inhibitors
Dominik Imfeld,
André Fischer,
Leithe Budel
et al.
Abstract:Lecithin:retinol acyltransferase (LRAT) is the main enzyme catalysing the esterification of retinol to retinyl esters and, hence, is of central importance for retinol homeostasis. As retinol, by its metabolite retinoic acid, stimulates fibroblasts to synthesize collagen fibres and inhibits collagen‐degrading enzymes, the inhibition of LRAT presents an intriguing strategy for anti‐ageing ingredients by increasing the available retinol in the skin. Here, we synthesized several derivatives mimicking natural lecit… Show more
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