Boosting image-guiding radiation therapy through W18O49 nanospheres and the second near-infrared light irradiation

Zheng, Nannan; Zhang, Shouhao; Wang, Lu; Zhang, Qi; Peng, Qiang; Jian, Lingrui; Bai, Yang; Feng, Yue; Shen, Jiachen; Wang, Ranxu; Jia, Jiao; Xu, Wanhai; Liu, Shaoqin

doi:10.1007/s12274-021-3814-0

Cited by 13 publications

(4 citation statements)

References 60 publications

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“…Consequently, an emerging hot topic is the efficient diagnosis of the condition, as well as quick and rational allocation of medical resources and the reduction of the medical burden. In recent decades, the main diagnosis and treatment methods for the early disease stages included magnetic resonance imaging (MRI) [1,2], X-ray computed tomography (CT) [3,4], positron emission tomography (PET) [5][6][7], single-photon emission computed tomography (SPECT) [8,9], magnetic particle imaging (MPI) [10,11], and optical fluorescent light imaging (FLI) [12,13]. It is worth noting that photoacoustic imaging (PAI) is expected to become a powerful tool for clinical detection due to its super-spatial resolution, high penetration, and non-invasive imaging technology [14,15].…”

Section: Introductionmentioning

confidence: 99%

Achieving Effective Multimodal Imaging with Rare-Earth Ion-Doped CaF2 Nanoparticles

Schomann

et al. 2022

Pharmaceutics

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Nowadays, cancer poses a significant hazard to humans. Limitations in early diagnosis techniques not only result in a waste of healthcare resources but can even lead to delays in diagnosis and treatment, consequently reducing cure rates. Therefore, it is crucial to develop an imaging probe that can provide diagnostic information precisely and rapidly. Here, we used a simple hydrothermal method to design a multimodal imaging probe based on the excellent properties of rare-earth ions. Calcium fluoride co-doped with ytterbium, gadolinium, and neodymium (CaF2:Y,Gd,Nd) nanoparticles (NPs) is highly crystalline, homogeneous in morphology, and displays a high biosafety profile. In addition, in vitro and ex vivo experiments explored the multimodal imaging capability of CaF2:Y,Gd,Nd and demonstrated the efficient performance of CaF2:Y,Gd,Nd during NIR-II fluorescence/photoacoustic/magnetic resonance imaging. Collectively, our novel diagnosis nanoparticle will generate new ideas for the development of multifunctional nanoplatforms for disease diagnosis and treatment.

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Section: Introductionmentioning

confidence: 99%

Achieving Effective Multimodal Imaging with Rare-Earth Ion-Doped CaF2 Nanoparticles

Schomann

et al. 2022

Pharmaceutics

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“…[ 243 ] For example, our group has utilized W 18 O 49 nanospheres to generate intracellular 1 O 2 and ·OH under X‐ray irradiation, resulting in three‐times enhancement in the inhibition of 4T1 cell proliferation. [ 244 ] Moreover, to increase O 2 concentrations in hypoxia tumor tissues, oxygen‐carrying and oxygen‐generating strategies have been also employed to improve nanomaterials‐sensitized radiotherapy. Gu's group synthesized SnS 2 @Fe 3 O 4 nanocomposite consisting of SnS 2 nanoplates and Fe 3 O 4 quantum dots and proposed a concept of X‐ray‐facilitated redox cycling of peroxidase‐like nanozyme for high‐efficiency and persistent ROS generation in tumor therapy.…”

Section: Nanomaterials That Manipulating Redox Balance In Cancer Cell...mentioning

confidence: 99%

Nanomaterials‐Induced Redox Imbalance: Challenged and Opportunities for Nanomaterials in Cancer Therapy

Wu,

Zhou,

et al. 2024

Advanced Science

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Cancer cells typically display redox imbalance compared with normal cells due to increased metabolic rate, accumulated mitochondrial dysfunction, elevated cell signaling, and accelerated peroxisomal activities. This redox imbalance may regulate gene expression, alter protein stability, and modulate existing cellular programs, resulting in inefficient treatment modalities. Therapeutic strategies targeting intra‐ or extracellular redox states of cancer cells at varying state of progression may trigger programmed cell death if exceeded a certain threshold, enabling therapeutic selectivity and overcoming cancer resistance to radiotherapy and chemotherapy. Nanotechnology provides new opportunities for modulating redox state in cancer cells due to their excellent designability and high reactivity. Various nanomaterials are widely researched to enhance highly reactive substances (free radicals) production, disrupt the endogenous antioxidant defense systems, or both. Here, the physiological features of redox imbalance in cancer cells are described and the challenges in modulating redox state in cancer cells are illustrated. Then, nanomaterials that regulate redox imbalance are classified and elaborated upon based on their ability to target redox regulations. Finally, the future perspectives in this field are proposed. It is hoped this review provides guidance for the design of nanomaterials‐based approaches involving modulating intra‐ or extracellular redox states for cancer therapy, especially for cancers resistant to radiotherapy or chemotherapy, etc.

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“…NIR light used in photothermal therapy has a limited penetration depth and fails to eradicate tumor cells in the deep tissue. Relatively, radiotherapy has a stronger penetrating ability, which can effectively break through the restriction while also improving the photothermal conversion capability (Zheng et al, 2021). At the same time, photothermal therapy can improve oxygen perfusion and relieve hypoxic environment, thus amplifying the effect of radiotherapy (Luo et al, 2020).…”

Section: Radiotherapy Combined With Phototherapymentioning

confidence: 99%

“…Research has shown that nanomaterials based on high-Z element can simultaneously promote photothermal therapy and radiotherapy. Zheng designed a W 18 O 49 nanosphere which showed excellent radiation sensitization and photothermal performance, promoted the production of 1 O 2 and • OH, increased radiation-induced DNA damage and significantly inhibited tumor cell proliferation and metastasis (Zheng et al, 2021). In addition, the combined application with nano-heterostructure is conducive to the production of ROS.…”

Section: Radiotherapy Combined With Phototherapymentioning

confidence: 99%

Recent Advance of Nanomaterial-Mediated Tumor Therapies in the Past Five Years

Hao

Xiang

et al. 2022

Front. Pharmacol.

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Cancer has posed a major threat to human life and health with a rapidly increasing number of patients. The complexity and refractory of tumors have brought great challenges to tumor treatment. In recent years, nanomaterials and nanotechnology have attracted more attention and greatly improved the efficiency of tumor therapies and significantly prolonged the survival period, whether for traditional tumor treatment methods such as radiotherapy, or emerging methods, such as phototherapy and immunotherapy, sonodynamic therapy, chemodynamic therapy and RNA interference therapeutics. Various monotherapies have obtained positive results, while combination therapies are further proposed to prevent incomplete eradication and recurrence of tumors, strengthen tumor killing efficacy with minimal side effects. In view of the complementary promotion effects between different therapies, it is vital to utilize nanomaterials as the link between monotherapies to achieve synergistic performance. Further development of nanomaterials with efficient tumor-killing effect and better biosafety is more in line with the needs of clinical treatment. In a word, the development of nanomaterials provides a promising way for tumor treatment, and here we will review the emerging nanomaterials towards radiotherapy, phototherapy and immunotherapy, and summarized the developed nanocarriers applied for the tumor combination therapies in the past 5 years, besides, the advances of some other novel therapies such as sonodynamic therapy, chemodynamic therapy, and RNA interference therapeutics have also been mentioned.

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Boosting image-guiding radiation therapy through W18O49 nanospheres and the second near-infrared light irradiation

Cited by 13 publications

References 60 publications

Achieving Effective Multimodal Imaging with Rare-Earth Ion-Doped CaF2 Nanoparticles

Achieving Effective Multimodal Imaging with Rare-Earth Ion-Doped CaF2 Nanoparticles

Nanomaterials‐Induced Redox Imbalance: Challenged and Opportunities for Nanomaterials in Cancer Therapy

Recent Advance of Nanomaterial-Mediated Tumor Therapies in the Past Five Years

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