Books reviews

The Tandem of Full Spin Analysis and qHNMR for the Quality Control of Botanicals Exemplified with Ginkgo biloba

“…In particular, the use of botanical dietary supplements (BDSs) and herbal remedies to improve health and treat different diseases and ailments has become a common practice among the general public. However, as the popularity of BDSs grows, concern about the quality of commercially available products also increases. − Considering the relatively complex chemical composition of herbal preparations, which may contain tens, hundreds, or even more bioactive and nonbioactive constituents in a wide concentration range, both qualitative and quantitative information becomes essential to ensure the consistency, safety, and efficacy of these materials.…”

“…The first group includes the ginkgolides A, B, C, and J (1−4), which are known antagonists of the platelet-activating factor receptor, and bilobalide (5), a potent neuroprotective agent. The second group is considered responsible for the antioxidant properties of Ginkgo extracts and comprises a large number of flavonol derivatives, primarily mono-, di-, and triglycosides, with quercetin (6), kaempferol (7), and isorhamnetin (8) as the main aglycones. In addition, the content of rutin ( 9), one of the major flavonol glycosides in Ginkgo biloba, was evaluated in order to test the applicability of this approach to the analysis of this class of compounds in complex botanical mixtures.…”

“…Figure 5. Experimental (exp) qHNMR spectrum of sample D50 (DMSO-d 6 , 600 MHz) and intensity-adjusted subspectra (in blue) of ginkgolide A (1), ginkgolide B (2), ginkgolide C (3), ginkgolide J (4), bilobalide (5), quercetin(6), kaempferol(7), and rutin(9). The subspectra were determined by PERCH iteration of individual 1 H fingerprints.…”

“…Figure 6. Identification of ginkgolide A (1), ginkgolide B (2), ginkgolide C (3), ginkgolide J (4), bilobalide (5), quercetin(6), kaempferol(7), and rutin (9) in a commercial Ginkgo preparation (sample D53) using a magnitude-mode 1 H, 1 H-COSY experiment (DMSO-d 6 , 600 MHz).…”