Book Reviews

Bone formation and the response of bone to implant insertion

“…The lower limb bud appears in the fourth menstrual week when the human femur is 2-5 mm in length. Each limb bud develops in a proximal sequence (the femur appears before the tibia) [4]. The cartilaginous model of the femoral head has appeared but has not yet been invaded by blood vessels.…”

“…After formation of the ossification center, growth in length occurs from the epiphyseal plate. Immature proliferating chrondroblasts originate from the area of the plate nearest the secondary ossification center called the zone of transitional cartilage [4] . The chondroblasts receive their nutrition from model of the pelvis is beginning to approach its adult form although ossification has not yet occurred.…”

“…(2) The interzone forms the early joint space and contains homogenous cellular areas. (3) The cartilaginous model of the femoral head has appeared but has not yet been invaded by blood vessels, (4) The diaphysis of the cartilaginous model has hypertrophied cells which semte phosphatase. Some calcification of the intracellular cartilaginous matrix has taken place.…”

“…The bars of calcified matrix form a scaffold upon which the primary trabeculae of bone deposit. Primitive mesenchymal cells mature into osteoblasts and lay down trabeculae in the region of the metaphysis [4,11,121. As these trabeculae pass down into the shaft of the bone, osteoblasts remodel them.…”

“…This type of biological background information is essential for progress in implant research. While the included references [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] are by n o means exhaustive, they will lead you to many of the key reference works.…”