Book Review: Hematology–Oncology Therapy

Boyiadzis, Michael; Lebowitz, Peter F.; Frame, James N.; Fojo, Tito; Cockerham, Michael B

doi:10.1345/aph.1h577

Cited by 19 publications

(53 citation statements)

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“…26 Only 7 texts cite either guideline in their lists of references. 10,11,[13][14][15]23,27 Nonetheless, treatment recommendations are consistent with these guidelines in only 2 of them. 10,15 Comparison with opioid use in other acute pain settings VOC is often treated by physicians with little experience in acute pain management in other settings.…”

Section: Textbook Recommendations For Opioid Use For Vocs In Scdmentioning

confidence: 99%

“…[6][7][8] These observations prompted a review of 19 textbooks in hematology, internal medicine, and emergency medicine published during or after the year 2003 to identify barriers to the effective management of VOCs in SCD. [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] (Specific chapters reviewed in each textbook are listed in Document S1, available on the Blood website; see the Supplemental Materials link at the top of the online article).…”

Section: Introductionmentioning

confidence: 99%

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Treatment and prevention of pain due to vaso-occlusive crises in adults with sickle cell disease: an educational void

Solomon

2008

Blood

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Pain due to vaso-occlusive crisis is the major cause of hospital use in sickle cell disease. Although available guidelines provide recommendations for opioid administration in this setting, only 4 (21%) of 19 medical textbooks present treatment regimens that are consistent with them. Moreover, only 7 texts (37%) note that addiction is infrequent in this population, while 11 (92%) of 12 texts provide such reassurance for cancer-related pain (P < .005). Finally, hydroxyurea use to decrease the frequency of vasoocclusive crises is completely defined only in 2 textbooks. Thus, most medical texts provide neither adequate information for the treatment or prevention of pain due to vaso-occlusive crisis in sickle cell disease nor reassurance of the unlikelihood of addiction in this population. In contrast, treatment recommendations for less common hematologic disorders are consistent with current standards in 53% to 84% of appropriate texts (P < .05). Limited knowledge regarding the principles and appropriateness of opioid therapy; a lack of evidence-based research on pain control; and misconceptions and prejudices about drug abuse and addiction contribute to this educational void. Thus, research and training on pain control in sickle cell disease are needed to parallel studies of environmental and genetic factors contributing to the known clinical heterogeneity of this disorder. (Blood. 2008;111:997-1003)

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Section: Textbook Recommendations For Opioid Use For Vocs In Scdmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Treatment and prevention of pain due to vaso-occlusive crises in adults with sickle cell disease: an educational void

Solomon

2008

Blood

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“…The most common side effects are nausea and/or vomiting. Aggressive and proactive management of these symptoms with antiemetic medications is extremely important to mitigate these effects, Another very frequent problem with the FOLFIRI chemotherapy is diarrhea which, like the nausea, requires active management by one's oncology team 6,7 . It has rarely been involved in hypersensitivity reactions as flushing, pruritus, abdominal pain,erythema, oedema developed over the face and thorax 8 .…”

Section: Discussionmentioning

confidence: 99%

Kolorektal kanserli hastada akut batını taklit eden radyolojik bulgular: FOLFIRI tedavisinin yan etkileri mi?

Karadeli¹,

Erbay²,

Koç³

2016

Cukurova Medical Journal (Çukurova Üniversitesi Tıp Fakültesi Dergisi)

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AbstractÖz Bowel perforation is an emergency problem, it presents as an acute abdomen. Computurize tomography (CT) is important imaging modality used to evaluate patients with acute abdomen. CT shows anatomical detail and intestinal wall, evaluating secondary signs of bowel disease within the surrounding mesentery and detecting even small amounts of extraluminal air or oral contrast leakage into the peritoneal cavity. The aim of this article is to illustrate acute abdominal CT findings due to FOLFIRI therapy of a patient with colorectal cancer. Interestingly, this patient was an emergency case based on radiologic findings, but he felt good, had no emergency problem clinically.Bağırsak perforasyonu, akut batını işaret eden tehlikeli bir problemdir. Bilgisayarlı tomografi (BT), akut batını olan hastaları değerlendirmede kullanılan önemli bir metoddur. BT, anotomik detayları ve bağırsak duvarını göstermekte, çevre mezenterde bağırsak hastalığı ile ilgili ikincil işaretleri değerlendirmekte ve peritonel kavitede oral kontrast sızıntıları ya da az miktarda ekstraluminal havayı saptamaktadır. Bu makalenin amacı, kolorektal kanserli hastada FOLFIRI tedavisine bağlı olarak akut batının BT bulgularını açıklamaktır. İlginç olarak, bu hastanın radyolojik bulgularının aciliyeti olmasına rağmen, hasta kendini iyi hissetmekte ve klinik olarak acil bir problemi bulunmamaktadır.

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“…Paclitaxel -no adjustment required. 33,34 B. Liver Function 1. Carboplatin -no dose adjustment required.…”

Section: Dosage Modifications a Renal Functionmentioning

confidence: 99%

“…Carboplatin -no dose adjustment required. 33 2. Paclitaxel -bilirubin and ALT/AST: a. Bilirubin less than 1.5 mg/dL and/or ALT/ AST greater than 2 times the ULN, reduce the dose 25%.…”

Section: Dosage Modifications a Renal Functionmentioning

confidence: 99%