Bony Manifestations of Thyrotoxicosis

Meunier, Pierre J.; Bianchi, Guy G.S.; Edouard, C.; Bernard, J; Courpron, P.; Vignon, G

doi:10.1016/s0030-5898(20)30490-9

Orthopedic Clinics of North America

1972

DOI: 10.1016/s0030-5898(20)30490-9

|View full text |Cite

Bony Manifestations of Thyrotoxicosis

Pierre J. Meunier

Guy G.S. Bianchi

C. Edouard

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1978

1995

Publication Types

Select...

Article6

Relationship

Self Cite0

Independent6

Authors

Journals

Cited by 152 publications

(1 citation statement)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The histomorphometric and dynamic bone changes in hyperthyroidism have previously been described in detail (Meunier et al 1972. The resulsts demonstrate that an excess of thyroid horm'one ( s ) stimulates bone formabion and bone resorption followed by a decrease in the amount of trabecular bone, an increase in cortical porosity and by mobilikation of bone mineral.…”

mentioning

confidence: 95%

Morphometric and Dynamic Studies of Bone Changes in Hypothyroidism

Melsen

Mosekilde

1978

Acta Pathologica Microbiologica Scandinavica Section A Patholog

View full text Add to dashboard Cite

Mosekilde, L. & Melsen, F. Morphometric and dynamic studies of bone changes in hypothyroidim. Aota path. microbhl. scand. Sect. A, 86: 56-62, 1978. Born biopsies were performed after tetracycline double-labelling by transfixing the right iliac crest in fourteen hypothymid patients. The bone changes in cortical and trabecular bone were determined by s:mple measurement and point counting on decalcified and undecalcified stained sections and compared to normal controls and to sex and age matched hyperthyroid patients. The amount of trabecular bone and the cortical porosity were unchanged in the hypothyroid patients compared to normal controls, whereas the mean oortical thickness was increased. The amount of osteoid and the length of the oaeoid seams were normal, whereas the mean width of the osteoid seams was decreased. The linear calcification rate in cancellous bone was decreased, as were the active calcification surfaces (tetracycline-labelled) and the percentage of osteoid covered surfaces active in mineralization. The mteoclastic resorption surfaces were unchanged in trabecular bone, whereas the osteoclastl activitty in cortical bone was decreased. The osteocytic outeolysis was normal. The bone changes in hypothyroidism were opposite to the changes in hyperthvroidism charaoterized by a very low bone turn-over w:th a reduced osteoid apposition and bone minerahization rate, an inaotive osteoclastic resorption in trabecular bone and a decreased mteoclastic resorption in captical bone. Mewre hiiumlolagique de la mitsse et de la r6mrption dw travees wseuses. Path. Biol. 12: 23, 24, Castro, J . H., Genuth, S. M., Klein, L.: Comparative response to parathyroid hormone in 1238-1243, 1964.

show abstract

mentioning

confidence: 95%

Morphometric and Dynamic Studies of Bone Changes in Hypothyroidism

Melsen

Mosekilde

1978

Acta Pathologica Microbiologica Scandinavica Section A Patholog

View full text Add to dashboard Cite

show abstract

Effect of Hyperthyroidism and Its Treatment on Bone Mineral Content

1985

View full text Add to dashboard Cite

A short course of recombinant human growth hormone treatment stimulates osteoblasts and activates bone remodeling in normal human volunteers

Brixen

Nielsen

Mosekilde

et al. 1990

Journal of Bone and Mineral Research

153

View full text Add to dashboard Cite

The effects of recombinant human growth hormone (rhGH) on biochemical markers of bone turnover and bone mineral content (BMC) were investigated in 20 normal male volunteers (aged 22-31 years) randomized to treatment for 7 days with either rhGH (0.1 IU/kg subcutaneously twice a day) or placebo. Serum somatomedin C rose during treatment (p less than 0.001) but was not significantly different from baseline at day 14. The fasting urinary hydroxyproline/creatinine (p less than 0.001) and calcium/creatinine ratios (p less than 0.01) increased during treatment and remained elevated for 4 and 2 weeks, respectively. Serum bone gamma-carboxyglutamic acid-containing protein (BGP) increased during treatment (p less than 0.001) and remained elevated for 6 months (p less than 0.02). Serum bone alkaline phosphatase (B-AP), after an initial fall in the treatment period (p less than 0.001), increased slightly in the following months (p less than 0.01). In the rhGH group BMC was significantly higher than the prestudy value at day 14 (p less than 0.05) but was unaltered at the end of study. The simultaneous increase in markers of bone resorption and formation during rhGH treatment followed by a decline in resorption parameters within a few weeks and the prolonged effect on BGP and B-AP demonstrate that rhGH treatment stimulates osteoblasts and activates bone remodeling.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Bony Manifestations of Thyrotoxicosis

Cited by 152 publications

References 34 publications

Morphometric and Dynamic Studies of Bone Changes in Hypothyroidism

Morphometric and Dynamic Studies of Bone Changes in Hypothyroidism

Effect of Hyperthyroidism and Its Treatment on Bone Mineral Content

A short course of recombinant human growth hormone treatment stimulates osteoblasts and activates bone remodeling in normal human volunteers

Contact Info

Product

Resources

About