Introduction: Ossification of auricular cartilage was first described in 1866 and its incidence is unclear, it is most commonly caused by trauma, frostbite, and inflammation but metabolic disorders have also been associated with it. Case Report: A 38-year-old male with long-term diagnosis of hypopituitarism with poor adherence to treatment presented with bilateral auricular calcification. The patient had improvement of pain in the ears once reported compliance with medication but calcification of ears showed to be not reversible with treatment. Conclusion: The pathophysiology of bilateral auricular calcification in metabolic cases remains unclear but cortisol deficiency seems to have an important role. Treatment with hormonal replacement shows improvement of pain but there was no reversibility of auricular calcification.