Bonnet Monkey Model for Pancreatic Changes in Induced Malnutrition

Abstract

Pancreatic degenerative lesions of identical nature could be induced in bonnet monkeys (Macaca radiata) fed protein-deficient tapioca or cassava starch-based and cornstarch-based diets for 3 or 5 months. Marked to severe lobular and acinar cell atrophy in animals fed low-protein diets resembled human pancreatic atrophy resulting from protein deficiency. Animals fed low-protein, high-carbohydrate diets showed lesions akin to tropical chronic calculus pancreatopathy with diabetes mellitus. The pancreatic lesions comprised moderate to marked acinar cell atrophy, marked islet hyperplasia or nesidioblastosis with hypertrophy and mucoid metaplasia of the duct epithelium. Mucoid vasculopathy of the pancreatic artery and arterioles was observed in all animals given proteindeficient diets. It was enhanced in those given additional carbohydrate. Identical lesions were observed after using either

Effects of the GLP-1 Receptor Agonist Dulaglutide on the Structure of the Exocrine Pancreas of Cynomolgus Monkeys

“…It is less clear if the effects of dulaglutide on food consumption, body weight, or general metabolic status could have contributed to the goblet cell alterations in this subset of monkeys. Bonnet monkeys provided mildly protein-deficient diets were observed to have a variety of structural changes in the pancreas, including ductular hyperplasia and goblet cell metaplasia, which supports the concept that nutritional factors can modify pancreatic duct morphology in the primate (Sandhyamani, Vijayakumari, and Nair 1999). In this protein-deficient model other structural changes such as acinar atrophy and islet cell hyperplasia were noted, changes that were not observed in the present study of dulaglutide.…”

Síndrome de emagrecimento progressivo dos calitriquídeos - processo de má absorção semelhante à doença celíaca humana - caracterização clínica, laboratorial e anatomopatológica

“…Alguns estudos experimentais utilizando dietas deficientes em proteína têm reproduzido quadro semelhante a marasmo e kwashiorkor em primatas não-humanos, sendo esses animais considerados como modelos para o estudo de má-nutrição (GEIST et al, 1972;RANA et al, 2001;SANDHYAMANI et al, 1999;WOLF, 1972).…”

“…Essas alterações podem ser observadas em humanos, assim como experimentalmente em primatas não-humanos (JUNIOR et al, 1997;RANA et al, 2001;SANDHYAMANI et al, 1999).…”

Genetic aspects of tropical calcific pancreatitis

“…However, TCP is uncommon in many regions of the world where malnutrition is rife [1][2][3][4], and furthermore, it is reported in all socioeconomic strata [2,12,14]. In addition, in monkeys fed low protein diets changes of pancreatic atrophy, but no inflammation, was observed [26]. The role of other environmental agents including oxidative stress related to xenobiotics and micronutrient deficiency, infections and autoimmunity has been proposed.…”