Bone volume–to–total volume ratio measured in trabecular bone by single‐sided NMR devices

Brizi, Leonardo; Barbieri, Marco; Baruffaldi, Fabio; Bortolotti, Villiam; Fersini, C.; Liu, Huabing; d’Eurydice, Marcel Nogueira; Obruchkov, Sergei; Zong, Fangrong; Galvosas, Petrik; Fantazzini, Paola

doi:10.1002/mrm.26697

Cited by 19 publications

(29 citation statements)

References 34 publications

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“…It is also cryogen‐free, therefore incurring negligibly low maintenance and running costs. Several researchers have investigated the potential utility of portable NMR for the imaging of biological tissues . The imaging of silicone breast implants is another biomedical (albeit not tissue imaging) application of portable NMR that is noteworthy in the context of the present study.…”

Section: Introductionmentioning

confidence: 99%

T₁‐based sensing of mammographic density using single‐sided portable NMR

Tourell

Ali

Hugo

et al. 2018

Magnetic Resonance in Med

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Purpose: A single-sided NMR instrument was used to investigate the ability of the T 1 relaxation constant to distinguish between regions of low and high mammographic density in human breast tissue.Methods: Measurements were performed on 5 breast slices obtained from 3 women undergoing breast reduction surgery or prophylactic mastectomy.Results: T 1 values measured in regions of high mammographic density in both the full breast slices (T 1 5 170 6 30 ms) and excised regions (T 1 5 160 6 30 ms) were found to be significantly different (P < .001) from those measured in regions of low mammographic density, in which T 1 5 120 6 10 ms was observed both in full slices and excised regions. There was no statistically significant difference between the T 1 values measured in the full breast slices and those measured in the excised regions. Conclusion:The findings suggest that portable NMR may provide a low-cost means of assessing mammographic density in vivo. K E Y W O R D S breast cancer risk, longitudinal spin-relaxation time constant (T 1 ), mammographic density, mammography, portable single-sided NMR | I NT ROD UCTI ONMammographic density (MD), also known as breast density, refers to the degree of radio-opacity of the breast as observed on an X-ray mammogram. Mammographic density is determined by the amount of the radiodense fibroglandular tissue (FGT), as opposed to the radiolucent adipose, or fat, tissue in the breast. In addition to having important implications for the efficacy of mammographic breast cancer risk screening, 1 MD is an independent risk factor for breast cancer, with women in the highest MD quartile having 4 to 6 times the risk of developing breast cancer than those in the lowest 10%, after normalization for body mass index and age. 2,3 Although the mammogram is still the current standard for Magn. Reson. Med. 2018;80:1243-1251.wileyonlinelibrary.com/journal/mrm

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Section: Introductionmentioning

confidence: 99%

T₁‐based sensing of mammographic density using single‐sided portable NMR

Tourell

Ali

Hugo

et al. 2018

Magnetic Resonance in Med

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“…[24] A single-side sensor has been applied to evaluate cleaning methods. [25,26] Not only stones but also paper, [27] wood, [28] bones, [29,30] and parchments [31] can be analyzed.…”

Section: Introductionmentioning

confidence: 99%

Identification of complex structures of paintings on canvas by NMR: Correlation between NMR profile and stratigraphy

Brizi

Bortolotti

Marmotti³

et al. 2020

Magnetic Reson in Chemistry

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Paintings on canvas are complex structures created by superimposing layers of different composition. Investigations on the structure of these artworks can provide essential information on their state of conservation, pictorial technique, possible overpaintings, and in planning a proper conservation plan. Standard methods of investigation consist in sampling a limited number of fragments for stratigraphic analyses. Despite the recognized validity of these methods, they are affected by evident limitations. Nuclear magnetic resonance (NMR) profiling, often named NMR stratigraphy, is an NMR relaxometry technique applied by single‐sided portable devices developed to overcome the disadvantages of microinvasive stratigraphic analyses. The potential of this approach on artworks, including wall paintings and a few examples of painted canvas, is described in the literature. In this study, NMR profiles of painting on canvas were examined by analyzing transverse relaxation time data by T2 quasi‐continuous distributions and the results compared with standard stratigraphic cross‐sections analysis. Combining signal intensity and T2 quasi‐continuous distributions, the identification of textile, preparatory, and paint layers was enhanced. The diction “NMR stratigraphy” for these inhomogeneous layered artworks is also discussed. Indeed, unlike the stratigraphic cross‐sections, NMR profiles provide information on a volume (flat slice), rather than on a surface, and the collected signal can derive from nonuniform and partially overlapping layers. This study paves the way for extensive investigations on relaxation time quasi‐continuous distributions in various binder/pigment mixtures in order to improve the reliability of NMR profile as an innovative, non–invasive, and nondestructive method for analyzing paintings on canvas.

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“…Portable NMR also has the added advantages of low purchasing and running cost and low maintenance, largely due to the absence of superconducting magnets (which obviates the need for cryogens). Portable‐NMR systems, most notably NMR‐MOUSE, are commercially available and have been used in a number of biomedical applications including testing of silicone breast implants and studies of various biological tissues, including tendon, articular cartilage, skin, and trabecular bone …”

Section: Introductionmentioning

confidence: 99%

Transverse relaxation‐based assessment of mammographic density and breast tissue composition by single‐sided portable NMR

Ali

Tourell

Hugo

et al. 2019

Magnetic Resonance in Med

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Purpose: Elevated mammographic density (MD) is an independent risk factor for breast cancer (BC) as well as a source of masking in X-ray mammography.High-frequency longitudinal monitoring of MD could also be beneficial in hormonal BC prevention, where early MD changes herald the treatment's success. We present a novel approach to quantification of MD in breast tissue using single-sided portable NMR. Its development was motivated by the low cost of portable-NMR instrumentation, the suitability for measurements in vivo, and the absence of ionizing radiation. Methods: Five breast slices were obtained from three patients undergoing prophylactic mastectomy or breast reduction surgery. Carr-Purcell-Meiboom-Gill (CPMG) relaxation curves were measured from (1) regions of high and low MD (HMD and LMD, respectively) in the full breast slices; (2) the same regions excised from the full slices; and (3) excised samples after H 2 O-D 2 O replacement. T 2 distributions were reconstructed from the CPMG decays using inverse Laplace transform. Results: Two major peaks, identified as fat and water, were consistently observed in the T 2 distributions of HMD regions. The LMD T 2 distributions were dominated by the fat peak. The relative areas of the two peaks exhibited statistically significant (P < .005) differences between HMD and LMD regions, enabling their classification as HMD or LMD. The relative-area distributions exhibited no statistically significant differences between full slices and excised samples. Conclusion: T 2 -based portable-NMR analysis is a novel approach to MD quantification. The ability to quantify tissue composition, combined with the low cost of instrumentation, make this approach promising for clinical applications. 1200 | ALI et AL. K E Y W O R D S breast cancer, mammographic density, NMR-MOUSE, nuclear magnetic resonance, single-sided portable NMR, transverse spin relaxation time constant (T 2 )

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Bone volume–to–total volume ratio measured in trabecular bone by single‐sided NMR devices

Cited by 19 publications

References 34 publications

T₁‐based sensing of mammographic density using single‐sided portable NMR

T₁‐based sensing of mammographic density using single‐sided portable NMR

Identification of complex structures of paintings on canvas by NMR: Correlation between NMR profile and stratigraphy

Transverse relaxation‐based assessment of mammographic density and breast tissue composition by single‐sided portable NMR

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Bone volume–to–total volume ratio measured in trabecular bone by single‐sided NMR devices

Cited by 19 publications

References 34 publications

T1‐based sensing of mammographic density using single‐sided portable NMR

T1‐based sensing of mammographic density using single‐sided portable NMR

Identification of complex structures of paintings on canvas by NMR: Correlation between NMR profile and stratigraphy

Transverse relaxation‐based assessment of mammographic density and breast tissue composition by single‐sided portable NMR

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T₁‐based sensing of mammographic density using single‐sided portable NMR

T₁‐based sensing of mammographic density using single‐sided portable NMR