Bone Turnover Markers Predict Bone Mass Development in Young Adult Men: A Five-Year Longitudinal Study

Darelid, Anna; Nilsson, Martin; Kindblom, Jenny M.; Mellström, Dan; Ohlsson, Claes; Lorentzon, Mattias

doi:10.1210/jc.2014-3947

Cited by 11 publications

(13 citation statements)

References 36 publications

(40 reference statements)

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“…After 5 years, those with an initial high level of OCN had the most favorable development in bone size and BMD . The study further demonstrated that those with a higher OCN at baseline were younger, and had experienced peak height velocity at a later age, compared with those with low OCN, possible indicating a lower maturation level . It is noteworthy that the study did not use Z‐scores to compare the changes during the 5‐year period, nor did the participants fast before OCN was examined …”

Section: Discussionmentioning

confidence: 88%

“…The predictive role of BTM for the future BMD was tested in 817 healthy young men with a mean age of 18.9 years at baseline . After 5 years, those with an initial high level of OCN had the most favorable development in bone size and BMD . The study further demonstrated that those with a higher OCN at baseline were younger, and had experienced peak height velocity at a later age, compared with those with low OCN, possible indicating a lower maturation level .…”

Section: Discussionmentioning

confidence: 98%

“…Participants in such studies are often postmenopausal women and men of similar age and the results might not apply in children and adolescents with T1D. The predictive role of BTM for the future BMD was tested in 817 healthy young men with a mean age of 18.9 years at baseline . After 5 years, those with an initial high level of OCN had the most favorable development in bone size and BMD .…”

Section: Discussionmentioning

confidence: 99%

“…Other independent mechanisms such as altered bone turnover with accumulation of older bone mineral and inadequate repair of microdamages have been suggested . Although BMD is not decreased in children and adolescents with T1D, bone turnover might still be impaired and some studies have indicated that BMD later in life can be predicted by bone turnover markers (BTM) in young adulthood …”

Section: Introductionmentioning

confidence: 99%

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Decreased markers of bone turnover in children and adolescents with type 1 diabetes

et al. 2020

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Background and aim: Adults with type 1 diabetes (T1D) have increased risk of bone fractures and decreased bone mineral density (BMD). Alterations in bone turnover have been suggested as the link between T1D and the impaired bone health. Furthermore, bone turnover has been suggested to have beneficial effects on glucose metabolism. This study aimed at describing bone turnover markers (BTM), and the relationship with glycemic control, in children and adolescents with T1D.Methods: A total of 173 (47% girls) children and adolescents aged 7.7 to 17.5 years with T1D for more than 1 year were included. Participants were evaluated by BMD together with measurements of selected BTM; two formation markers: osteocalcin (OCN) and procollagen type-1 amino-terminal propeptide (P1NP) and one resorption marker, C-terminal cross-linked telopeptide of type-1 collagen (CTX). BTM were converted into Z-scores utilizing new national references.Results: Mean OCN Z-score (−0.68 ± 1.31), P1NP Z-score (−0.33 ± 1.03) and CTX Z-score (−0.43 ± 1.10) were all significantly lower than the reference population (P < .001). No associations were seen between BTM and T1D duration. BMD Z-score was comparable to the reference population and associated with none of individual BTMs. CTX Z-score was negatively associated with HbA1c (P = .007) independent of both exogenous and residual endogenous insulin.Conclusions: Markers of bone formation and resorption were decreased in children and adolescents with T1D. CTX Z-score associated negatively with HbA1c adjusted for insulin treatment and endogenous insulin production indicating a potential

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Decreased markers of bone turnover in children and adolescents with type 1 diabetes

et al. 2020

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“…Two previously published reference cohorts from the two large city regions in the southwest of Sweden were pooled and used as controls in this study: (i) 1068 population-based young adult men in the age range of 18-25 years from the greater Gothenburg area (the GOOD study [30,31]), and (ii) 221 men and women in the age range of 18-30 years from the greater Malm€ o area [32]. The pooled control cohort consisted of 1181 men and 108 women in the age range of 18-30 years.…”

Section: Subjectsmentioning

confidence: 99%

Altered body composition profiles in young adults with childhood-onset inflammatory bowel disease

Sigurdsson

Schmidt

Mellström

et al. 2020

Scandinavian Journal of Gastroenterology

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Background: Patients with inflammatory bowel disease (IBD) often develop alterations in body composition in terms of their proportions of lean mass and fat mass, as well as reduced bone mineral density (BMD). However, there are limited data on the skeletal muscle index (SMI) and percentage fat (fat %) for young adults with childhood-onset IBD. Our aim was to investigate the body compositions of these patients, with the focus on SMI and fat %. Methods: Body composition was estimated by dual x-ray absorptiometry for 94 young adults with childhood-onset IBD aged 18-27 years, 65 of whom had ulcerative colitis. The Z-scores for SMI, fat %, and BMD were calculated using the normative data from 1,289 individuals with corresponding age. Based on the SMI and fat % Z-scores, each patient was classified as having a body composition profile that was: (i) normal; (ii) obese (fat % Z-score >1); (iii) myopenic (SMI Z-score < À1); or (iv) myopenic-obese. Results: A higher proportion of young adults with childhood-onset IBD had a body composition profile classified as myopenic (24%) or myopenic-obese (9%), as compared to the controls (myopenic [16%, p ¼ .016]; myopenic-obese [2%, p ¼ .002]). Patients with the myopenic or myopenic-obese profile had significantly lower total body BMD Z-scores (À1.3 ± 0.7 and À1.4 ± 0.9, respectively) than patients with the normal profile (À0.2 ± 1.1; p < .001 and p ¼ .004, respectively). Diagnosis of IBD in childhood represented an additional risk for low BMD, regardless of SMI Z-score. Conclusion: Young adults with childhood-onset IBD have a high risk for having altered body composition traits.

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Bone Turnover in Young Adult Men: Cross-Sectional Determinants and Associations With Prospectively Assessed Bone Loss

Verroken

Zmierczak

Goemaere

et al. 2017

Journal of Bone and Mineral Research

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Biochemical markers of bone turnover are higher in young adult men than in middle-aged men or young adult women. Nonetheless, little is known about the determinants and clinical significance hereof. The present study examined determinants of serum bone turnover markers in men around peak bone mass age, and explored whether bone turnover at this age predicts subsequent changes in bone mass. We used cross-sectional and longitudinal data from 973 and 428 healthy men, respectively, aged 25 to 45 years at baseline, including baseline procollagen type I amino-terminal propeptide (P1NP), osteocalcin, and C-terminal telopeptide of type I collagen (CTX) from fasting serum samples, baseline questionnaire-assessed physical activity levels, and baseline and follow-up dual-energy X-ray absorptiometry-derived areal bone mineral density (aBMD) and body composition. Mean follow-up time was 12.4 ± 0.4 years. At baseline, all bone turnover markers were inversely associated with total body fat mass (β ≤ -0.20, p < 0.001), and positively with physical activity during sports activities (β ≥ 0.09, p ≤ 0.003), and, albeit not independently from fat mass, total body lean mass (β ≥ 0.20, p ≤ 0.003). Mean annual aBMD changes in the longitudinal cohort were -0.19% ± 0.24% at the total body, -0.14% ± 0.42% at the spine, -0.49% ± 0.47% at the femoral neck, and -0.25% ± 0.37% at the total hip (all p < 0.001). Higher bone turnover markers at baseline were associated with larger decreases in aBMD at all measurement sites (β ≤ -0.08, p ≤ 0.081 for P1NP; β ≤ -0.16, p ≤ 0.002 for osteocalcin; and β ≤ -0.21, p < 0.001 for CTX). In conclusion, our findings show that sports activities and body composition, primarily fat mass, are the main identified determinants of bone turnover in men around peak bone mass age. Further, bone turnover at this age is an important determinant of subsequent changes in bone mass, with higher levels of bone turnover markers being associated with greater decreases in aBMD. © 2017 American Society for Bone and Mineral Research.

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Bone Turnover Markers Predict Bone Mass Development in Young Adult Men: A Five-Year Longitudinal Study

Abstract: A high OC level at the age of 19 predicts a favorable development in BMD, BMC, and bone size between 19 and 24 years of age.

Cited by 11 publications

References 36 publications

Decreased markers of bone turnover in children and adolescents with type 1 diabetes

Decreased markers of bone turnover in children and adolescents with type 1 diabetes

Altered body composition profiles in young adults with childhood-onset inflammatory bowel disease

Bone Turnover in Young Adult Men: Cross-Sectional Determinants and Associations With Prospectively Assessed Bone Loss

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