Bone turnover markers in medicamentous and physiological hyperprolactinemia in female rats

Radojkovic, Danijela; Pešić, Milica; Ristić, Tatjana

doi:10.2298/vsp1406559r

Cited by 2 publications

(2 citation statements)

References 45 publications

(36 reference statements)

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“…The literature data regarding OC levels in drug-induced HP are contradictory, with some studies reporting increased levels in certain conditions [28,37] and others showing decreased levels [15,38,39]. In this study, sulpiride-induced HP with calcium and vitamin D supplementation resulted in a significant decrease in OC levels.…”

Section: Changes In Bone Turnover Markers During Sulpiride-induced Hpmentioning

confidence: 50%

Significance of Duodenal Prolactin Receptor Modulation by Calcium and Vitamin D in Sulpiride-Induced Hyperprolactinemia

Radojkovic,

Pesic,

Radojkovic

et al. 2024

Medicina

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Background and Objectives: Hyperprolactinemia, as a potential side-effect of some antipsychotic medications, is associated with decreased bone density and an increased risk of fractures. This study investigates whether calcium and vitamin D supplementation affects prolactin receptor (Prlr) gene expression in the duodenum, vertebrae, and kidneys of female rats with sulpiride-induced hyperprolactinemia. Materials and Methods: Twenty-one-week-old female Wistar rats were assigned to three groups: Group S consisted of ten rats who received sulpiride injections (10 mg/kg) twice daily for 6 weeks; Group D (10 rats) received daily supplementation of 50 mg calcium and 500 IU vitamin D along with sulpiride for the last 3 weeks; and Group C consisting of seven age-matched nulliparous rats serving as a control group. Real-time PCR was used to assess Prlr gene expression in the duodenum, vertebrae, and kidneys. Results: In Group S, Prlr gene expression was notably decreased in the duodenum (p < 0.01) but elevated in the vertebrae and kidneys compared to Group C. Conversely, Group D exhibited significantly increased Prlr expression in the duodenum (p < 0.01) alongside elevated expression in the vertebrae and kidneys. Conclusions: In sulpiride-induced hyperprolactinemia, decreased Prlr gene expression in the duodenum may lead to reduced intestinal calcium absorption. Consequently, prolactin may draw calcium from the skeletal system to maintain calcium balance, facilitated by increased Prlr gene expression in the vertebrae. However, vitamin D supplementation in sulpiride-induced hyperprolactinemia notably enhances Prlr gene expression in the duodenum, potentially ameliorating intestinal calcium absorption and mitigating adverse effects on bone health.

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Section: Changes In Bone Turnover Markers During Sulpiride-induced Hpmentioning

confidence: 50%

Significance of Duodenal Prolactin Receptor Modulation by Calcium and Vitamin D in Sulpiride-Induced Hyperprolactinemia

Radojkovic,

Pesic,

Radojkovic

et al. 2024

Medicina

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“…However, ALP levels of rats in the three groups treated with ZGGJ showed no remarkable differences from the model group, which may be due to ZGGJ decreasing bone resorption rather than increasing bone formation. However, P1NP, which is another important marker of bone formation [ 16 ], showed an increasing trend in ovariectomized mice. Ryu et al [ 17 ] reported similar results in castrated rats in which P1NP increased gradually after orchiectomy, the generally accepted approach to induce osteoporosis in male rats.…”

Section: Discussionmentioning

confidence: 99%

The Antiosteoporosis Effects of Zhuanggu Guanjie Pill In Vitro and In Vivo

Chai

Zhang

et al. 2018

BioMed Research International

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We investigated the beneficial effects and underlying mechanisms of Zhuanggu Guanjie (ZGGJ) pill in osteoporosis in vitro and in vivo. Bone marrow macrophages from 4–6-week-old mice were cultured in the presence of macrophage colony-stimulating factor (15 ng/mL) and receptor activator of nuclear factor-κB ligand (30 ng/mL). Osteoclast differentiation was determined by quantification of tartrate-resistant acid phosphatase activity. Gelatin zymography was used to detect the activity of matrix metalloproteinases in osteoclasts. Ovariectomized rats were administered orally with estradiol valerate or ZGGJ for 8 weeks. Blood was collected to measure serum indices. Tibiae were harvested to carry out bone microcomputed tomography scanning, histomorphological analysis, and bone strength determination. ZGGJ inhibited tartrate-resistant acid phosphatase activity, matrix metalloproteinase 9 expression, and bone resorption in vitro. At doses of 0.55, 1.1, and 2.2 g/kg, ZGGJ exerted significant osteoprotective effects including inhibition of bone turnover markers and improved tibia bone strength in ovariectomized rats. Microcomputed tomographic analysis showed that ZGGJ improved the trabecular architecture with increased connectivity density and trabecular thickness and decreased trabecular spacing. These results revealed that ZGGJ prevents bone loss induced by ovariectomy in rats and that inhibition of bone resorption is involved in the bone-protective effects of ZGGJ.

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Bone turnover markers in medicamentous and physiological hyperprolactinemia in female rats

Cited by 2 publications

References 45 publications

Significance of Duodenal Prolactin Receptor Modulation by Calcium and Vitamin D in Sulpiride-Induced Hyperprolactinemia

Significance of Duodenal Prolactin Receptor Modulation by Calcium and Vitamin D in Sulpiride-Induced Hyperprolactinemia

The Antiosteoporosis Effects of Zhuanggu Guanjie Pill In Vitro and In Vivo

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