Bone Turnover Markers and Vitamin D Status in Postmenopausal Turkish Women

Abstract

The aim of this study was to examine some biochemical markers of bone metabolism such as C-telopeptide of type 1 collagen (CTx), procollagen I N-peptide (PINP), 25 hydroxy vitamin D [25(OH)D], parathormone (PTH), and alkaline phosphatase (total- and bone-ALP) in postmenopausal Turkish women, and to evaluate the influence of dietary factors on these parameters. This cross-sectional study comprised 70 postmenopausal and 25 premenopausal subjects from a similar socio-economical status. The postmenopausal group was further stratified with regard to vitamin plus calcium supplementation. A fasting blood sample was obtained for the biochemical analysis of bone markers. Ca, P, tALP, and CTx levels were significantly higher in postmenopausal women free of supplementation than those in premenopausal period; whereas 25(OH)D concentrations were below the reference value in both groups. Supplementations of vitamin and calcium resulted in significantly lower levels of PINP in the postmenopausal group (p = 0.017). A significant association was found between plasma 25(OH)D level and frequency of fish consumption. Dietary strategies to fortify calcium and vitamin D intake should be considered to decrease the complications due to D hypovitaminosis after the onset of menopause.

A randomised controlled trial comparing the efficacy of micellised and fat-soluble vitamin D3 supplementation in healthy adults

“…Although most studies report no change in bone resorption/formation markers, some show decrease in either resorption marker alone or both following supplementation. Evaluation of bone markers in the present study may have provided additional information on bone turnover status ( 20 – 23 ) .…”

The increase of osteopontin and β‐carboxy‐terminal cross‐linking telopeptide of type I collagen enhances the risk of hip fracture in the elderly

“…Carboxy‐terminal cross‐linking telopeptide of type I collagen is a significant marker of bone metabolism . Urinary CTX‐II is closely correlated with the dynamic bone turnover of knees signified by scintigraphy, thereby contributing to joint space narrowing and osteophyte severity along with progression of osteophytes in osteoarthritis .…”

SEASONAL VARIATION IN HbA1c AND 25(OH) VITAMIN D CONCENTRATIONS IN THE TURKISH POPULATION: COULD RAMADAN BE CHANGING EXPECTATIONS?

“…In recent years, the growing public awareness of vitamin D functions, as well as bone metabolism, has led to increased vitamin D supplementation. Also, seasonal variations of vitamin D concentration depending on latitude, diet, and clothing habits have been investigated in previous studies (20,21). Changes in HbA1c and 25(OH)D levels have been reported between seasons or months throughout the year and in both hemispheres (22)(23)(24).…”