Bone tissue growth enhancement by calcium phosphate coatings on porous titanium alloys: The effect of shielding metal dissolution product

Ducheyne, Paul; Bianco, P. D.; Kim, Cheol-Sang

doi:10.1016/0142-9612(92)90030-r

Cited by 20 publications

(7 citation statements)

References 23 publications

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“…[6][7][8][9][10][11][12][13][14]20 This bonding been demonstrated not only by microscopic examination, 18,19,21,28,29 but also by supporting evidence produced from mechanical testing. 2,30 Our results from measurements of bone mineralization rates and bone integration confirm this. They also repeat the finding of Dhert 1 that in a pushout test there is a higher ISS than would be obtained with a bioinert material.…”

Section: Discussionsupporting

confidence: 90%

“…1 The fundamental problems for the long-term use of these devices are associated with the mechanical and biological incompatibility between the components, particularly metal, and host bone. 2 Attention is being paid to developing composite materials as alternatives to metals for a new generation of isoelastic, structural orthopedic implant applications. 3−5 The search for an improvement to the fixation of implants in bone resulted decades ago in the introduction of calcium phosphate coatings in orthopeCorrespondence to: P. A. Revell Contract grant sponsor: Engineering Physical Science Research Council dics.…”

Section: Introductionmentioning

confidence: 99%

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In vivo biocompatibility and mechanical study of novel bone-bioactive materials for prosthetic implantation

Zhang

Revell

Evans

et al. 1999

J. Biomed. Mater. Res.

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Two epoxy materials with or without adhesively bonded hydroxyapatite (HA) coatings were studied for their biocompatibility and mechanical pushout strength using in vivo implantation in the rabbit lower femur for a duration of 10 days to 6 months. Both were two-part epoxies cured at room temperature for 24 h, with material 1 (Ampreg 26; SP Systems Limited, Cowes, UK) postcured at 110 degrees C (Tg approximately 80 degrees C) and Material 2 (CG5052; Ciba Geigy Limited, Cambridge, UK) at 125 degrees C (Tg approximately 120 degrees C). Implantation in dead rabbit bone was performed to provide mechanical baseline levels. Polymethylmethacrylate (PMMA) and conventionally HA-coated titanium alloy (Ti-6Al-4V) were used as control materials. In the biological study, different fluorescent dyes were used to label newly formed bone. After 6 weeks of implantation, results from mechanical pushout tests showed that the interfacial shear strength (ISS) values were significantly higher than for dead bones with each of the different implants (p < .01-.001). HA-coated material 2 showed a significantly higher ISS value than the uncoated material (p < .05) after 6 weeks' implantation. However, the ISS value for the uncoated material 2 was significantly higher than for PMMA controls (p < .05). No significant differences in the ISS values were shown between HA-coated materials 1 and 2 and Ti-6Al-4V on in vivo implantation for 6 weeks. Failure points of the pushout test from the three HA-coated materials were defined by scanning electron microscopy. Specimens implanted with both HA-coated epoxies were fractured within the HA-coatings or the bone, while with HA-coated Ti-6Al-4V cracked between the coating and metal implant. The percentage of bone in contact with the implant surface was obtained by image analysis which showed that there were no significant differences between different materials after short time implantation (up to 6 week). Long-term implantation of the HA-coated material 2 showed that the percentage of bone contact had increased from 52.8+/-1.1% (6 week) to 80.0+/-0.3% (3 months) (p < .01) and remained at 81.0+/-0.8% (6 months). Measurements of bone mineralization rate (BMR) showed that after 3 weeks of implantation, there were no significant differences between PMMA and uncoated materials 1 and 2. After 6 weeks, the BMRs in animals implanted with either HA-coated material 1 or 2 were significantly higher than with HA-coated Ti-6Al-4V (p < .05-.0001 in both cases), but with HA-coated material 2 was lower than with this material uncoated (p < .05-.001). No significant differences were found between the two HA-coated epoxy materials. In addition, there were always lower BMRs during the third week of implantation than other periods regardless of biomaterial implanted. The study indicated that the adhesively bonded HA-coated novel epoxy materials were superior to conventional plasma-sprayed Ti-6Al-4V implants with respect to both BMR and bone integration with the implant surfaces. Adhesively bonded HA-coated epoxy materials h...

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

In vivo biocompatibility and mechanical study of novel bone-bioactive materials for prosthetic implantation

Zhang

Revell

Evans

et al. 1999

J. Biomed. Mater. Res.

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“…[195]. Ti, Al, and V release rates were determined in vitro for Ti-6Al-4V alloy both with and without a CP coating.…”

Section: Surface Texturingmentioning

confidence: 99%

“…It was found that (i) the CP-coated specimens contained no measurable amounts of Ti, (ii) the Al ion solution around the CP-coated specimen was significantly greater than the concentration around the non-coated specimens; however (iii) Al did not increase significantly with time, at least up to 4 weeks immersion. The CP coating produced a significant increase of biological fixation, yet at the same time a greater Al release into solution, calling into question the value of calcium phosphate ceramic coating in shielding adverse metal passive dissolution to enhance bone growth [195]. …”

Section: Surface Texturingmentioning

confidence: 99%

Dental Implant Systems

Oshida

Tuna

Aktören

et al. 2010

IJMS

175

115

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Among various dental materials and their successful applications, a dental implant is a good example of the integrated system of science and technology involved in multiple disciplines including surface chemistry and physics, biomechanics, from macro-scale to nano-scale manufacturing technologies and surface engineering. As many other dental materials and devices, there are crucial requirements taken upon on dental implants systems, since surface of dental implants is directly in contact with vital hard/soft tissue and is subjected to chemical as well as mechanical bio-environments. Such requirements should, at least, include biological compatibility, mechanical compatibility, and morphological compatibility to surrounding vital tissues. In this review, based on carefully selected about 500 published articles, these requirements plus MRI compatibility are firstly reviewed, followed by surface texturing methods in details. Normally dental implants are placed to lost tooth/teeth location(s) in adult patients whose skeleton and bony growth have already completed. However, there are some controversial issues for placing dental implants in growing patients. This point has been, in most of dental articles, overlooked. This review, therefore, throws a deliberate sight on this point. Concluding this review, we are proposing a novel implant system that integrates materials science and up-dated surface technology to improve dental implant systems exhibiting bio- and mechano-functionalities.

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“…Other treatment options, the man-made devices, such as bone cement fillers and prosthetics made of metals, ceramics and polymers are also used for bone defect repair or replacing damaged bone tissue. All the conventional methods for bone repair and replacement can be long, painful and have the possibility of being rejected by the body (Ducheyne et al, 1992). Alternative approaches have been heavily researched and investigated based on a tissue engineering strategy, in an effort to overcome the inherent limitations of the currently available solutions to bone defects.…”

Section: Introductionmentioning

confidence: 99%