Bone tissue engineering and bone regeneration

Kanczler, Janos M.; Wells, Julia; Gibbs, David; Marshall, Karen; Tang, Daniel

doi:10.1016/b978-0-12-818422-6.00052-6

Cited by 16 publications

(13 citation statements)

References 102 publications

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“…Tissue engineering strategies, including the regeneration, repair and healing of bone [1], myocardium [2], skin [3] and other soft tissues, use temporary synthetic scaffolds to aid the natural healing of tissue defects. Electrospinning is a well-known method for fabricating micro-and nano-fiber mats from polymer solutions or melts [4].…”

Section: Introductionmentioning

confidence: 99%

Electrospun PCL Fiber Mats Incorporating Multi-Targeted B and Co Co-Doped Bioactive Glass Nanoparticles for Angiogenesis

Chen

Galusková²,

Kaňková³

et al. 2020

Materials

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Vascularization is necessary in tissue engineering to keep adequate blood supply in order to maintain the survival and growth of new tissue. The synergy of biologically active ions with multi-target activity may lead to superior angiogenesis promotion in comparison to single-target approaches but it has been rarely investigated. In this study, polycaprolactone (PCL) fiber mats embedded with B and Co co-doped bioactive glass nanoparticles (BCo.BGNs) were fabricated as a tissue regeneration scaffold designed for promoting angiogenesis. BCo.NBGs were successfully prepared with well-defined spherical shape using a sol-gel method. The PCL fiber mats embedding co-doped bioactive glass nanoparticles were fabricated by electrospinning using benign solvents. The Young’s moduli of the nanoparticle containing PCL fiber mats were similar to those of the neat fiber mats and suitable for scaffolds utilized in soft tissue repair approaches. The mats also showed non-cytotoxicity to ST-2 cells. PCL fiber mats containing BCo.BGNs with a relatively high content of B and Co promoted the secretion of vascular endothelial growth factor to a greater extent than PCL fiber mats with a relatively low B and Co contents, which demonstrates the potential of dual ion release (B and Co) from bioactive glasses to enhance angiogenesis in soft tissue engineering.

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Section: Introductionmentioning

confidence: 99%

Electrospun PCL Fiber Mats Incorporating Multi-Targeted B and Co Co-Doped Bioactive Glass Nanoparticles for Angiogenesis

Chen

Galusková²,

Kaňková³

et al. 2020

Materials

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“…It is noteworthy that it is not necessary for the biomaterial to resemble the bone structure since it is a temporary resorbable substitute material for promoting bone repair. A number of properties have been found to contribute significantly to biocompatibility, including porosity, surface topography, biodegradability, and bioresorbability 27 . The biocomposite shown here formed without covalent crosslinking and behaves as a carrier material made of collagen, which allows introducing silica nanoparticles into the tissue during surgery.…”

Section: Discussionmentioning

confidence: 98%

A collagen‐silica‐based biocomposite for potential application in bone tissue engineering

Echazú

Renou

Álvarez

et al. 2021

J Biomedical Materials Res

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Bone is a hierarchical material that has inspired the design of biopolymer‐derived biocomposites for tissue engineering purposes. The present study sought to synthesize and perform the physicochemical characterization and biocompatibility of a collagen‐silica‐based biocomposite for potential application in bone tissue engineering. Ultrastructure, biodegradability, swelling behavior, and biocompatibility properties were analyzed to gain insight into the advantages and limitations to the use of this biomaterial as a bone substitute. Scanning electron microscopy analysis showed a packed‐collagen fibril matrix and silica particles in the biocomposite three‐dimensional structure. As shown by analysis of in vitro swelling behavior and biodegradability, it would seem that the material swelled soon after implantation and then suffered degradation. Biocompatibility properties were analyzed in vivo 14‐days postimplantation using an experimental model in Wistar rats. The biocomposite was placed inside the hematopoietic bone marrow compartment of both tibiae (n = 16). Newly formed woven bone was observed in response to both materials. Unlike the pure‐collagen‐tissue interface, extensive areas of osseointegration were observed at the biocomposite‐tissue interface, which would indicate that silica particles stimulated new bone formation. Agglomerates of finely particulate material with no inflammatory infiltrate or multinucleated giant cells were observed in the bone marrow implanted with the biocomposite. The biocomposite showed good biocompatibility properties. Further studies are necessary to evaluate their biological behavior over time.

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“…The healing process can be supported by porous scaffolds that facilitate cell adhesion and growth, while allowing the diffusion of oxygen and nutrients to the adhered cells [105]. In order to mimic the same environment as that in real bone, the scaffold ought to feature optimal porosity for osteoblasts to properly diffuse, and contain osteogenic factors to promote bone repair [106]. The supporting scaffold is usually loaded with derivatives from the apatite family, which are known to induce cell differentiation in biological tissue [107].…”

Section: Bone Tissue Engineeringmentioning

confidence: 99%

Colloidal systems toward 3D cell culture scaffolds

Vila-Parrondo

García‐Astrain

Liz‐Marzán

2020

Advances in Colloid and Interface Science

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Three-dimensional porous scaffolds are essential for the development of tissue engineering and regeneration, as biomimetic supports to recreate the microenvironment present in natural tissues. To successfully achieve the growth and development of a specific kind of tissue, porous matrices should be able to influence cell behavior by promoting close cell-cell and cell-matrix interactions. To achieve this goal, the scaffold must fulfil a set of conditions, including ordered interconnected porosity to promote cell diffusion and vascularization, mechanical strength to support the tissue during continuous ingrowth, and biocompatibility to avoid toxicity. Among various building approaches to the construction of porous matrices, selected strategies afford hierarchical scaffolds with such defined properties. The control over porosity, microstructure or morphology, is crucial to the fabrication of high-end, reproducible scaffolds for the target application. In this review, we provide an insight into recent advances toward the colloidal fabrication of hierarchical scaffolds. After identifying the main requirements for scaffolds in biomedical applications, conceptual building processes are introduced. Examples of tissue regeneration applications are provided for different scaffold types, highlighting their versatility and biocompatibility. We finally provide a prospect about the current state of the art and limitations of porous scaffolds, along with challenges that are to be addressed, so these materials consolidate in the fields of tissue engineering and drug delivery.

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Bone tissue engineering and bone regeneration

Cited by 16 publications

References 102 publications

Electrospun PCL Fiber Mats Incorporating Multi-Targeted B and Co Co-Doped Bioactive Glass Nanoparticles for Angiogenesis

Electrospun PCL Fiber Mats Incorporating Multi-Targeted B and Co Co-Doped Bioactive Glass Nanoparticles for Angiogenesis

A collagen‐silica‐based biocomposite for potential application in bone tissue engineering

Colloidal systems toward 3D cell culture scaffolds

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