Bone Tissue Engineering

Reichert, Johannes C.; Kuaha, Kunnika; Rijckaert, B.; Nöth, Ulrich; Hutmacher, Dietmar W.

doi:10.1142/9789812833303_0006

Cited by 1 publication

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“…In 1995, the concept of bone tissue engineering was proposed based on the combination of cells, engineering and materials, as well as suitable biochemical and physicochemical factors to improve or replace biological tissues. 1,2 Although tissue engineering has been developed for decades, it is still a hot topic in repairing and replacing bone defect. In bone tissue engineering, one of the key factors is the preparation of tissue scaffold for promoting the adhesion and growth of seed cells or new cells.…”

Section: Introductionmentioning

confidence: 99%

Nano-hydroxyapatite/polyamide66 composite scaffold conducting osteogenesis to repair mandible defect

Cai

Jiang

Zhang

et al. 2018

Journal of Bioactive and Compatible Polymers

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In this study, nano-hydroxyapatite/polyamide66 composite scaffold was prepared by combining thermally induced phase separation and particulate leaching. The morphological structure and compositional phases of the scaffold were analyzed, while the in vitro and in vivo biological behaviors were assessed by comparing with the control of the commercial porous polyethylene (MEDPOR ®). Results indicate that nano-hydroxyapatite/polyamide66 scaffold showed excellent biocompatibility and the ability to accelerate bone marrow mesenchymal stem cells differentiation in vitro and bone marrow mesenchymal stem cells/nano-hydroxyapatite/polyamide66-engineered constructs exhibited much better in vivo biocompatibility and osteoconductivity with the surrounding host bone than bone marrow mesenchymal stem cells/MEDPOR constructs. The porous nano-hydroxyapatite/ polyamide66 scaffold demonstrates a potential to be applied in the orthopedic or maxillofacial surgery.

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Section: Introductionmentioning

confidence: 99%