Bone Tissue and Biomaterial Design Based on the Anisotropic Microstructure

Nakano, Takayoshi

doi:10.1007/978-3-662-46836-4_1

Cited by 6 publications

(4 citation statements)

References 49 publications

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“…4 In our previous review articles reported variety of the preferential alignment of the BAp c-axis of various type bones by the micro-beam X-ray diffractometer (mXRD) system equipped with two-dimensional detectors. 10,11 The orientation c-axis of BAp crystallites analyzed by mXRD offers a new index as a bone quality parameter; which can obtain relative intensity ratio of the 002 diffraction peak to the 310 peak in the X-ray prole. 3,12 Additionally, bone quality was dened by the National Institute of Health (NIH) in 2000 as parameters contributing to bone strength independent of bone mineral density (BMD).…”

Section: Introductionmentioning

confidence: 99%

Bone apatite anisotropic structure control via designing fibrous scaffolds

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Bone apatite anisotropic structure control via designing fibrous scaffolds

et al. 2020

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“…Bone is a highly calcified tissue consisting of collagen fibril and biological apatite (BAp) with several nanoscale to microscale hierarchical levels [1,2]. The multiscale structure of bone tissue indicates a highly anisotropic structure, which is strongly associated with the collagen fibril orientation and the direction of the c-axis of the BAp crystals [3,4].…”

Section: Introductionmentioning

confidence: 99%

Oriented siloxane-containing vaterite/poly(lactic acid) composite scaffolds for controlling osteoblast alignment and proliferation

Lee

Kiyokane

Kasuga

et al. 2019

Journal of Asian Ceramic Societies

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Bone tissue has an anisotropic structure, which is strongly associated with the collagen fibril orientation and the direction of the c-axis of the bone apatite crystal. The bone regeneration process contains two main phases: bone mineral density (BMD; bone quantity) restoration and reconstruction of the bone apatite c-axis orientation (bone quality), which is the dominant factor for the mechanical properties of bone. Hence, restoration of the bone quality and quantity is required for bone tissue regeneration. In this work, novel, oriented siloxanecontaining vaterite/poly(lactic acid) composite scaffolds were developed by controlling the cell alignment and proliferation, which play an important role in regenerating the bone quality and quantity, respectively. Our strategy controlled the cell alignment and proliferation using a morphological design of the scaffolds and the ions released from the siloxanecontaining vaterite. The scaffolds were designed to control of the cell alignment, which successfully induced cell orientation along the fibermats. In addition, the released ions from the siloxane-containing vaterite improved osteoblast proliferation, indicating that the released Mg 2+ and silicate ions stimulated cell adhesion and proliferation. These results indicated that the fibermats developed in this work could be used for bone tissue regeneration scaffolds that enable the recovery of bone quality and quantity.

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“…The dentistry represents one of the most growing areas with commercially available products for regenerative medicine proposals. The teeth loss leads to the local bone reabsorption, decreasing the bone volume [1][2][3], rendering the site infeasible for the implant installation. Thus, before the implant insertion, it is necessary to increase the local bone volume.…”

Section: Introductionmentioning

confidence: 99%

Bone-bioglass graft - an alternative to improve the osseointegration

Lopes

Furlan

Correr

et al. 2022

PAC

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Homologues and xenogenous bones are currently the most used grafts in dentistry because of their performance. However, some inherent disadvantages of these materials have not yet been overcome, such as the lack of biological properties to improve the new bone formation in situ and the long remodeling time. The main aim of this work was to improve the performance of the commercial bone-based grafts and study its properties in vitro. For this purpose, rat bone was combined with bioglass, a synthetic biomaterial that displays high degradation kinetics and bioactivity properties, endowed with biological properties. The sol-gel method was used for 45S5 bioglass (45S5) synthesis, using TEOS and water soluble salts as starting materials. 45S5 was then associated with the rat bone, generating the new graft. FTIR results indicated the hydroxyapatite formation after the bioactivity tests. SEM and bioactivity results were used to assess the evolution of the graft. The bioactivity tests showed that after 30 days the mass gain of about 30 wt.% was due to the deposition of hydroxyapatite crystals at the surface of the grafts, suggesting the potential properties of this new graft for application in implantology.

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Bone Tissue and Biomaterial Design Based on the Anisotropic Microstructure

Cited by 6 publications

References 49 publications

Bone apatite anisotropic structure control via designing fibrous scaffolds

Bone apatite anisotropic structure control via designing fibrous scaffolds

Oriented siloxane-containing vaterite/poly(lactic acid) composite scaffolds for controlling osteoblast alignment and proliferation

Bone-bioglass graft - an alternative to improve the osseointegration

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