Bone-specific alkaline phosphatase activity in dairy cows

Mohebbi, Abdonnaser; Khaghani, Amin; Mohammadnia, Ahmad Raza

doi:10.1007/s00580-009-0900-1

Cited by 12 publications

(10 citation statements)

References 22 publications

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“…It is possible to increase the specificity of total ALP tests for the bone-specific isoform by using lectin precipitation and heat inactivation before testing, and, in general, this has yielded more definitive results. Higher and more variable bone ALP activity was observed in young growing cattle than in mature animals (Yamagishi et al 2009), with a decline in bone ALP activity noted in cows with increasing parity/age (Mohebbi et al 2010). Furthermore, in early lactation in dairy cows, serum ALP activity increased (Sato et al 2005) and this was attributable to increases in both bone and liver isoforms.…”

Section: Balp As a Marker Of Bone Mineralisationmentioning

confidence: 93%

New candidate markers of phosphorus status in beef breeder cows

et al. 2017

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Determining the phosphorus (P) status of cattle grazing P-deficient rangelands in northern Australia is important for improving animal production in these areas. Plasma inorganic P concentration is currently the best diagnostic marker of dietary P deficiency in growing cattle but is not suitable for assessing the P status of breeder cows, which often mobilise substantial bone and soft tissue reserves in late pregnancy and lactation. Markers of bone turnover offer potential as markers of P status in cattle, as they reflect bone mobilisation or bone formation. Recent experiments investigating the physiology of beef breeder cows during diet P deficiency have indicated that the ratio of plasma total calcium concentration to plasma inorganic P concentration might be suitable as a simple index of P deficiency. However, a more specific measure of increased bone mobilisation in P-deficient breeders is plasma concentration of C-terminal telopeptide of Type 1 collagen. Also, plasma concentration of bone alkaline phosphatase is a marker of defective bone mineralisation in dietary P deficiency. These candidate markers warrant further investigation to determine their predictive value for P deficiency in cattle.

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Section: Balp As a Marker Of Bone Mineralisationmentioning

confidence: 93%

New candidate markers of phosphorus status in beef breeder cows

et al. 2017

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“…Plasma t-ALP and BAP activities were measured spectrophotometrically using a LabAssay ALP kit (Wako Pure Chemical Industries, Ltd., Osaka, Japan). Plasma BAP activity was measured using the heat-inactivation method [ 14 ]; plasma samples were incubated at 56°C for 15 min, and aliquots were removed for measurement of heat-insensitive ALP. The plasma BAP activity was calculated by subtracting the heat-insensitive ALP activity from the t-ALP activity.…”

mentioning

confidence: 99%

Changes in the plasma levels of several bone markers in newborn calves during the first two days of life

Hatate

Shinya

Matsuo-Sato

et al. 2016

The Journal of Veterinary Medical Science

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ABSTRACT. The fluctuations in the plasma levels of several bone markers were investigated in newborn calves. Experiment 1 monitored the postnatal changes in the plasma levels of tartrate-resistant acid phosphatase isoform 5b (TRAP5b), total alkaline phosphatase (t-ALP) and bone-specific alkaline phosphatase (BAP) in four calves. These markers increased significantly from 9−20 hr after the first colostrumsuckling compared with the values immediately after birth. Experiment 2 evaluated changes in the plasma TRAP5b, t-ALP, BAP and type I collagen cross-linked N-telopeptide (NTx) levels within 2 days post-birth in five calves with successful passive immunization via colostrum (non-deficient group) and five others with poor colostrum intake (deficient group). The non-deficient group had significantly higher plasma levels of the four parameters around 12 hr of life compared with the deficient group. The results suggest that the increase in plasma bone markers in calves in the first day of life is related to the colostrum intake.

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“…The plasma HYP concentration was determined spectrophotometrically [ 4 ]. Plasma BALP activity was measured spectrophotometrically using the heat-inactivation method [ 15 ]. Briefly, 200 µl of plasma samples were incubated at 56°C for 15 min.…”

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Diurnal Variation of Plasma Bone Markers in Japanese Black Calves

Matsuo

Togashi

Sasaki

et al. 2014

The Journal of Veterinary Medical Science

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To evaluate diurnal variation of plasma bone markers, blood samples were collected from five calves at 2-hr intervals throughout a 24-hr period. Tartrate-resistant acid phosphatase isoform 5b (TRAP5b), carboxy-terminal collagen crosslinks of type-I collagen (CTX), hydroxyproline, bone specific alkaline phosphatase (BALP) and osteocalcin were measured. Cosinor analysis showed a significant rhythm in all bone markers. The acrophase of each bone marker appeared from the early to late morning. The percentage ratio of the amplitude to mesor and the within-subject variability for CTx and osteocalcin were significantly larger than those for TRAP5b and BALP. This marked diurnal variation in five bone markers suggested that the time of blood sampling should be fixed when studying bone marker concentrations in bovine plasma.

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Bone-specific alkaline phosphatase activity in dairy cows

Cited by 12 publications

References 22 publications

New candidate markers of phosphorus status in beef breeder cows

New candidate markers of phosphorus status in beef breeder cows

Changes in the plasma levels of several bone markers in newborn calves during the first two days of life

Diurnal Variation of Plasma Bone Markers in Japanese Black Calves

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