Bone-sparing effect of soy protein in ovarian hormone–deficient rats is related to its isoflavone content

Arjmandi, Bahram H.; Birnbaum, Roger S.; Goyal, Noopur; Getlinger, Mary J.; Juma, Shanil; Alekel, L.; Hasler, Clare M.; Drum, Melinda L.; Hollis, Bruce W.; Kukreja, Subhash C.

doi:10.1093/ajcn/68.6.1364s

Cited by 184 publications

(95 citation statements)

References 23 publications

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“…Because bile acids are synthesized from cholesterol, enhancing their excretion would enhance hepatic bile acid synthesis, triggering an up-regulation of LDL-C receptors, thus reducing the circulating concentrations of cholesterol carried by LDL-C and other atherogenic particles (Cho et al 2008). SOphytoestrogens may prevent bone loss through reducing the lipid profile, thereby increasing osteoblastic activity (Arjmandi et al 1998). Additionally, the positive effects of the other selected phytoestrogen rich oil (SO) on the bone health were recorded as achieved by the decreased lipid profile.…”

Section: Discussionmentioning

confidence: 99%

Role of phytoestrogenic oils in alleviating osteoporosis associated with ovariectomy in rats

2012

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The objective of this study was to elucidate the effect of soybean oil (SbO) and sesame oil (SO) supplemented diets on bone biomarkers changes in OVX (ovariectomized) rats. The current data exhibited significant decrease in BMD (bone mineral density), accompanied with marked depletion in the level of Ca, P and Mg in both serum and bone of OVX rats. Also, serum estrogen, total protein, HDL-C (high density lipoprotein cholesterol), bone NO levels were decreased in OVX rats. However, a significant increase in the level of serum TL (total lipids), TC (total cholesterol), TG (triglycerides), LDL-C (low density lipoprotein cholesterol), VLDL-C (very low density lipoprotein cholesterol), urine minerals (Ca, P, Mg), as well as serum, bone and urine ALP (alkaline phosphatase) and ACP (acid phosphatase) activity were recorded in OVX rats. Further changes were also detected by the increased level of urine hydroxyproline, serum parathyroid hormone and osteocalcin, as well as urea and creatinine level in both serum and urine. On the other hand, when OVX rats were fed on SbO (soy bean oil) (15 % w/w) or SO (sesame oil) (10 % w/w) supplemented diets, the data recorded a significant improvement in all the above mentioned parameters. So, it can be concluded that consumption of SbO or SO supplemented diets might be considered as a functional food for retarding risks of osteoporosis associated with estrogen deficiency in OVX states.

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Section: Discussionmentioning

confidence: 99%

Role of phytoestrogenic oils in alleviating osteoporosis associated with ovariectomy in rats

2012

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“…Kaempferol is a flavanoid associated with good skeletal health [43,44]. It has been demonstrated to overcome the deleterious effect on bone density in oestrogen deficiency [43], to exhibit an antiosteoclastogenic effect [45,46] and to promote osteoblast differentiation [42]. Layer-by-layer nano-matrix was prepared by the sequential absorption of two bilayers of sodium alginate and protamine sulphate over the CaCO 3 loaded kaempferol microparticles.…”

Section: Nanotechnology For Osteoporosismentioning

confidence: 99%

Nanotechnology towards prevention of anaemia and osteoporosis: from concept to market

Shukla

Dasgupta

Ranjan

et al. 2017

Biotechnology & Biotechnological Equipment

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The application of nanotechnology in medicine, diagnostics, therapeutics, drug delivery, etc. in order to overcome the limitations faced by these fields has already been established. Anaemia and osteoporosis are two of the most widely prevalent iron and calcium deficiency diseases among women. Conventional drugs for both have their inherent limitations which can be overcome by nanotechnology. Nanonization of drugs has been established as a very efficient way to enhance the bioavailability and absorption of the drug in the gastrointestinal tract. In addition to this, encapsulation of drugs in solid lipid nanoparticles is also employed to increase the stability of the drug in the gastrointestinal tract and to facilitate its controlled release. Nanotechnology is also applied in bone tissue engineering to prepare bone grafts for bone injury. Nanotechnology-based bone grafts have shown to possess enhanced mechanical properties and better biocompatibility and osteoconduction than the conventional bone grafts. This review article highlights the research trends and challenges of nanotechnology based drugs to combat iron deficiency anaemia and osteoporosis. This review outlines the recent research trends in nano-drugs and touches on issues concerning the market, industries and patents pertaining to drugs for anaemia and osteoporosis. To provide the safety and risk factors of nanomaterials, we have briefly highlighted the toxicological aspects of nanomaterials used in drugs.

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“…(Ishida et al, 1998) • 22.7% soy protein diet -Reduced bone loss as effectively as estrogen. (Arjmandi et al, 1998;Harrison et al, 1998) • 8 mg genistin/day in the diet -Increased bone density compared to casein diet. (Blair et al, 1996) Lactating ovariectomized Sprague-Dawley rat model of osteoporosis • 0.5 mg genistein/day for 2 weeks in the diet -Prevented bone loss as effective as Premarin.…”

Section: Serum and Urine Concentrations Of Isoflavones In Adult Rats mentioning

confidence: 99%

Animal Models Impacted by Phytoestrogens in Commercial Chow: Implications for Pathways Influenced by Hormones

Brown

Setchell

2001

Laboratory Investigation

267

239

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SUMMARY:It is generally not known that most commercial rodent diets are formulated with soy protein and deliver large daily doses of isoflavones to animals throughout their lifespan, including the in utero period. Here, we demonstrate that isoflavones are bioavailable and show that commercial rodent diets universally used by animal facilities lead to very high steady-state serum isoflavone concentrations in adult rats (2613 Ϯ 873 ng/mL) and mice (2338 Ϯ 531 ng/mL), exceeding the animal's endogenous estrogen level by 30,000-to 60,000-fold. We demonstrate the maternal-fetal intrauterine transfer of isoflavones in animals fed a standard Purina 5001 soy-containing diet and show that newborn rat pups have high serum isoflavones levels (540 Ϯ 174 ng/mL) that are maintained throughout the suckling period by passage of isoflavones into maternal milk. These findings have profound implications for all animal experiments, including multigenerational studies and studies of transgenic animals, especially if biochemical or morphological end-points are influenced by the hormonal or nonhormonal properties of phytoestrogens. These compounds have the potential to modulate genotypic and phenotypic expression in general, and therefore, all investigators should be vigilant to the phytoestrogen composition of commercial rodent diets because there is a history of potent biological effects in larger animals and in humans from high circulating isoflavone concentrations. (Lab Invest 2001, 81:735-747).A lthough phytoestrogens are ubiquitous in the plant kingdom, it is soybeans and foods made with purified soy proteins that are by far the greatest contributors of isoflavones to animal and human diets (Coward et

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Bone-sparing effect of soy protein in ovarian hormone–deficient rats is related to its isoflavone content

Cited by 184 publications

References 23 publications

Role of phytoestrogenic oils in alleviating osteoporosis associated with ovariectomy in rats

Role of phytoestrogenic oils in alleviating osteoporosis associated with ovariectomy in rats

Nanotechnology towards prevention of anaemia and osteoporosis: from concept to market

Animal Models Impacted by Phytoestrogens in Commercial Chow: Implications for Pathways Influenced by Hormones

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