Bone Sclerosis in Multiple Myeloma

Engels, Edward P.; Smith, Robert C.; Krantz, Simon

doi:10.1148/75.2.242

Cited by 36 publications

(2 citation statements)

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“…Reitain et al (1980) reported that only 3.3% of their multiple myeloma patients radiographically presented osteolysis at the lesion rim. Others also report that myeloma may demonstrate diffuse osteolysis, although all admit that this finding is rare (Wiederman et al, 1966;Engels & Smith, 1971;Brown & Paterson, 1973;Kricun, 1983). The slight osteolysis observed by several investigators may indicate a more substantial periosteal reaction.…”

Section: Multiple Myelomamentioning

confidence: 99%

Metastatic carcinoma: palaeopathology and differential diagnosis

Marks

Hamilton

2006

Intl J of Osteoarchaeology

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A 62 year-old contemporary white female diagnosed with metastatic carcinoma of the breast was examined after skeletonisation. She never received chemical, hormonal or radiation therapy. Because of the confirmed clinical diagnosis, lack of medicinal intervention, and quality of bone preservation, this specimen provides a comparative standard for metastatic carcinoma and differential diagnosis of idiopathic dry bone pathology. We detail gross and radiographic bone response to this disease and differentially diagnose the skeleton against Langerhans cell histiocytosis and multiple myeloma, conditions capable of modifying bone in characteristic patterns that may mimic metastatic carcinoma.

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Section: Multiple Myelomamentioning

confidence: 99%

Metastatic carcinoma: palaeopathology and differential diagnosis

Marks

Hamilton

2006

Intl J of Osteoarchaeology

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“…The most characteristic is a circumscribed, purely destructive lesion of varying size and resembling a punched-out cavity radiologically. We have, however, been able to find references to 20 cases of multiple myeloma with osteosclerotic lesions (Rypins, 1933;Krainin, D'Angio, and Smelin, 1949;Kohler and Laur, 1950;Galgano, 1955;Lewin and Stein, 1958;Engels, Smith, and Krantz, 1960;Porter, 1961;Tuboku-Metzger, 1961;Yentis, 1961). In three of these 20 cases, a coexistent polyneuropathy was described.…”

Section: Discussionmentioning

confidence: 99%