Bone scans in the diagnosis of bone crisis in patients who have Gaucher disease.

Pediatric non-neuronopathic Gaucher disease: presentation, diagnosis and assessment. Consensus statements

“…Evidence of old bone crises can be sought with a 99m Tc methylene diphosphonate bone scan. These studies may be helpful in deciding whether enzyme therapy is indicated [25]. Dual-energy X-ray absorptiometry (of the lumbar spine and nondominant femoral neck) at baseline may be used to measure generalized osteopenia in children with Gaucher disease, but requires age-specific normative data [6,31,36].…”

Paediatric non-neuronopathic Gaucher disease: recommendations for treatment and monitoring

“…When MRI is not available, a bone scan is a sensitive way to assess bone marrow infiltration throughout the body [27] and also has proven efficacy in diagnosing bone crises [35].…”

Re-evaluation of bone pain in patients with type 1 Gaucher disease suggests that bone crises occur in small bones as well as long bones

“…Bone crises in the small bones of the hands and 127 feet also occur but have been described rarely; they have been reported 128 previously in studies of the hands [24] and feet [25] and in series of bone 129 scans in Gaucher disease [7]. 130 In this study, we retrospectively examined the incidence of bone 131 pain and bone crises, including small bone pain, in patients followed 132 at the Rabin Medical Center, Petah Tikva, Israel, before and following 133 the initiation of ERT.…”

“…Patients' 142 spleen status [25][26][27][28] and history of pregnancy [29,30] were document-143 ed as possible risk factors for exacerbated bone disease. 144 For patients under the Center's care at the time of bone crises, bone 145 crises were confirmed by radionuclide bone scan [7] or MRI imaging (or 146 both) (see Figs. [1][2][3][4].…”

“…[1][2][3][4]. For patients with a history of bone crises referred 147 by other physicians, bone crises were considered to have occurred if im-148 aging showed evidence of old foci of avascular necrosis supported by 149 adequate documentation from the referring physicians (it is acknowl-150 edged that this definition, published previously by our group and others 151 [6,7], is not universally accepted by the Gaucher community). Self-152 reports by patients were also included if they were considered by the 153 authors to be clinically authentic although they may not have been asso-154 ciated with specific dates of occurrence or with any evidence from im- The clinical and demographic characteristics of patients with bone cri-176 ses are shown in Table 1S (Supplementary material).…”