Bone repair inhibited by indomethacin: Effects on bone metabolism and strength of rabbit osteotomies

Keller, Johnny; Biinger, Cody; Andreassen, Troels T.; Bak, Bue; Lucht, Ulf

doi:10.3109/17453678709146360

Cited by 100 publications

(60 citation statements)

References 13 publications

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“…Radiographic callus formation was evident in 21 days, compatible with normal fracture healing (Piermattei et al, 1997) and consistent with other reports (Aguiar et al, 2013) and even other rodent species (Keller et al, 1987). Nonunion is a possible outcome when the necessary rest is not done (Quesenberry and Carpenter, 2011), fortunately this was not the case.…”

Section: Discussionsupporting

confidence: 74%

Tibial osteosynthesis in a guinea pig (Cavia porcellus)

Macedo¹,

Goulart

Alievi

et al. 2015

Arq. Bras. Med. Vet. Zootec.

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A guinea pig was presented with left pelvic limb lameness after unknown trauma. Radiographs revealed complete oblique diaphyseal fracture of the distal third of the left tibia and fibula. The guinea pig was treated surgically with an intramedullary pin. The day after surgery the guinea pig was using the limb comfortably (grade 1/5 lameness). Callus formation was obtained 21 days after surgery without complications.Keywords: wild animals, Kirschner wires, tibia, fracture RESUMO Um cobaio foi atendido com claudicação de membro pélvico esquerdo após trauma desconhecido. Radiografias revelaram fratura completa oblíqua da diáfise do terço distal da tíbia e fíbula esquerdas. O cobaio foi tratado cirurgicamente com um pino intramedular. No dia seguinte à cirurgia, o paciente utilizava o membro confortavelmente (grau 1/5 de claudicação). Calo ósseo foi obtido 21 dias após a cirurgia, sem complicações.

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Section: Discussionsupporting

confidence: 74%

Tibial osteosynthesis in a guinea pig (Cavia porcellus)

Macedo¹,

Goulart

Alievi

et al. 2015

Arq. Bras. Med. Vet. Zootec.

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“…28 This group of drugs has been found to inhibit prostaglandin-mediated bone remodelling in vitro and in animal models in a dose-dependent fashion. 19 Numerous reports have shown their interference with the healing of bone in both experimental and human fractures, 13,[15][16][17][18]22,23,25 which may be due to inhibition of cyclo-oxygenase 2 activity, 29 and this may also be expected to occur with the newest anti-inflammatory drugs, the COX2 inhibitors.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, in multiple animal models and clinical studies, indomethacin and other non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to impair healing of fractures with reduced callus and altered remodelling of the Haversian systems. [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] Our aim was to determine if indomethacin, when used for prophylaxis for HO after surgery for acetabular fracture, increases the risk of nonunion in patients with associated fracture of a long bone.…”

mentioning

confidence: 99%

Heterotopic ossification prophylaxis with indomethacin increases the risk of long-bone nonunion

Burd

Hughes

Anglen

2003

The Journal of Bone and Joint Surgery. British volume

238

160

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“…These drugs inhibit disordered osteoclast activity, retard woven-fibered bone tissue formation, and impair fracture healing [1,2,23,34,37,52,54,62,63]. COX inhibitors are, however, very efficient drugs in the treatment of postoperative inflammation and pain in orthopaedic trauma and surgery.…”

Section: Introductionmentioning

confidence: 99%

Parecoxib and Indomethacin Delay Early Fracture Healing: A Study in Rats

Dimmen

Nordsletten

Madsen

2009

Clinical Orthopaedics &Amp; Related Research

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Nonsteroidal antiinflammatory drugs (NSAIDs) are used to reduce inflammatory response and pain. These drugs have been reported to impair bone metabolism. Parecoxib, a specific COX-2 inhibitor, exerts an inhibitory effect on the mineralization of fracture callus after a tibial fracture in rats. Decreased bone mineral density (BMD) at a fracture site may indicate impairment of early healing, casting doubt on the safety of using COX-2 inhibitors during the early treatment of diaphyseal fractures. Fortytwo female Wistar rats were randomly allocated to three groups. They were given parecoxib, indomethacin, or saline intraperitoneally for 7 days after being subjected to a closed tibial fracture stabilized with an intramedullary nail. Two and 3 weeks after surgery, the bone density at the fracture site was measured using dual energy xray absorptiometry (DEXA). Three weeks after the operation the rats were euthanized and the healing fractures were mechanically tested in three-point cantilever bending.Parecoxib decreased BMD at the fracture site for 3 weeks after fracture, indomethacin for 2 weeks. Both parecoxib and indomethacin reduced the ultimate bending moment and the bending stiffness of the healing fractures after 3 weeks. These results suggest COX inhibitors should be avoided in the early phase after fractures.

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Bone repair inhibited by indomethacin: Effects on bone metabolism and strength of rabbit osteotomies

Cited by 100 publications

References 13 publications

Tibial osteosynthesis in a guinea pig (Cavia porcellus)

Tibial osteosynthesis in a guinea pig (Cavia porcellus)

Heterotopic ossification prophylaxis with indomethacin increases the risk of long-bone nonunion

Parecoxib and Indomethacin Delay Early Fracture Healing: A Study in Rats

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