Bone Repair in Periodontal Defect Using a Composite of Allograft and Calcium Sulfate (DentoGen) and a Calcium Sulfate Barrier

Mazor, Ziv; Mamidwar, Sachin; Ricci, John L.; Tovar, Nick

doi:10.1563/aaid-joi-d-10-00006.1

Cited by 25 publications

(22 citation statements)

References 22 publications

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“…Freeze-dried bone allografts (FDBA) have been extensively used for treatment of periodontal defects [216,217,218,219,220,221,222,223,224,225]. Compelling evidence suggests that the health risks associated with fresh frozen bone is minimal [226], and clinical success of grafting procedures is high [227].…”

Section: Natural Transplants and Synthetic Bone Replacement Graft mentioning

confidence: 99%

Bone Replacement Materials and Techniques Used for Achieving Vertical Alveolar Bone Augmentation

Sima²,

2015

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Alveolar bone augmentation in vertical dimension remains the holy grail of periodontal tissue engineering. Successful dental implant placement for restoration of edentulous sites depends on the quality and quantity of alveolar bone available in all spatial dimensions. There are several surgical techniques used alone or in combination with natural or synthetic graft materials to achieve vertical alveolar bone augmentation. While continuously improving surgical techniques combined with the use of auto- or allografts provide the most predictable clinical outcomes, their success often depends on the status of recipient tissues. The morbidity associated with donor sites for auto-grafts makes these techniques less appealing to both patients and clinicians. New developments in material sciences offer a range of synthetic replacements for natural grafts to address the shortcoming of a second surgical site and relatively high resorption rates. This narrative review focuses on existing techniques, natural tissues and synthetic biomaterials commonly used to achieve vertical bone height gain in order to successfully restore edentulous ridges with implant-supported prostheses.

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Section: Natural Transplants and Synthetic Bone Replacement Graft mentioning

confidence: 99%

Bone Replacement Materials and Techniques Used for Achieving Vertical Alveolar Bone Augmentation

Sima²,

2015

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“…Hydroxyapatite, calcium sulfate (CS), coralline, calcium carbonate has been successfully used in the treatment of a variety of bone defects . CS, also known as POP (Plaster of Paris), is a self‐setting, biocompatible, and osteoconductive biomaterial with a long history for the treatment of skeletal defects . Despite these advantages, CS cements show a too fast resorption rate and are unable to provide a long‐term 3D framework during the osteogenesis process .…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3] CS, also known as POP (Plaster of Paris), is a self-setting, biocompatible, and osteoconductive biomaterial with a long history for the treatment of skeletal defects. 2 Despite these advantages, CS cements show a too fast resorption rate and are unable to provide a long-term 3D framework during the osteogenesis process. [4][5][6] To solve this problem, a biocompatible and osteoconductive hydrogel calcium carbonate has been incorporated into CS formulations.…”

Section: Introductionmentioning

confidence: 99%

Preparation of a calcium carbonate‐based bone substitute with cinnamaldehyde crosslinking agent with potential anti‐inflammatory properties

Dewi

Ana

Jansen

2017

J Biomedical Materials Res

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Calcium sulfate (CS), also known as POP (Plaster of Paris) is a self-setting, biocompatible, and osteoconductive biomaterial with a long history for the treatment of skeletal defects. However, CS cements show a too fast resorption rate and are unable to provide a long-term 3D framework during the osteogenesis process. In our previous studies, it was found that the incorporation of CaCO and CaCO hydrogel provided enhanced mechanical and degradation properties of POP composites. Furthermore, it was also found that the use of cinnamaldehyde to crosslink CaCO hydrogel may have some advantages, for example to crosslink the hydrogel and to act as anti-inflammatory control agent. The objective of the current study was to evaluate the effect of adding cinnamaldehyde crosslinked CaCO hydrogel into POP on the diametral tensile strength, weight loss, age swelling, degradation, cinnamaldehyde release, and porosity. The following composites were prepared: POP/HCin-025 (25% addition of hydrogel microsphere) and POP/HCin-050 (50% addition of hydrogel microsphere). The composites were assessed on their diametral tensile strength, weight loss of the POP composite, age swelling, degradation of the hydrogel CaCO , cinnamaldehyde release, and porosity, as well as XRD-patterns and FT-IR spectra. It was confirmed from the study that incorporation of cinnamaldehyde into CaCO hydrogel system significantly increased the mechanical strength of the POP composite. Weight loss, swelling ratio in both acid to neutral pH, and biodegradability of the POP composites were controllable by the addition of cinnamaldehyde-CaCO hydrogel. Moreover, the cinnamaldehyde incorporated into the hydrogel was proven to be released in a controlled manner. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1055-1062, 2017.

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“…Calcium sulfate (CS) has been shown to be completely bio absorbable, osteoconductive, allow fibroblast migration, do not cause an inflammatory response and also do not elevate serum calcium levels. Recently, it has been shown that CS can be manufactured into a granular composite of CS and poly-l-lactic acid to decrease the degradation rate [18] .…”

Section: Calcium Hydroxidementioning

confidence: 99%

Biomimetic Materials in Dentistry

Ali¹,

Saraf²,

Patil³

et al. 2017

Res. Rev. J Mat. Sci

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Bone Repair in Periodontal Defect Using a Composite of Allograft and Calcium Sulfate (DentoGen) and a Calcium Sulfate Barrier

Cited by 25 publications

References 22 publications

Bone Replacement Materials and Techniques Used for Achieving Vertical Alveolar Bone Augmentation

Bone Replacement Materials and Techniques Used for Achieving Vertical Alveolar Bone Augmentation

Preparation of a calcium carbonate‐based bone substitute with cinnamaldehyde crosslinking agent with potential anti‐inflammatory properties

Biomimetic Materials in Dentistry

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