Bone Remodelling Dynamics

Frost, Harold M.; Straatsma, C. R.

doi:10.1097/00006534-196402000-00013

Cited by 89 publications

(28 citation statements)

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“…The deposition of calcified aggregates, dif ferent from bone apposition, has clearly been demonstrated in the present study. Therefore, it seems difficult to confirm the hypothesis of Frost [11][12][13][14] who holds that the enlargement of the bone marrow cavity observed in the elderly is linked with a con tinuous periosteal bone growth. To some ex tent, periosteal calcifications also participate in this phenomenon of subperiosteal expan sion of bones.…”

Section: Discussionmentioning

confidence: 97%

Age Changes in Human Bone: A Microradiographic and Histological Study of Subperiosteal and Periosteal Calcifications

Zagba-Mongalima

Goret-Nicaise²,

Dhem³

1988

Gerontology

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Age changes in subperiosteal areas of human bones are described in 56 subjects of both sexes aged 18–96 years, using microradiographic and histological analysis of thick undecalcified sections from the midshaft of the femur, the tibia, the third metacarpal bone and the third rib. Till the age of 39, most areas of the subperiosteal bone consist of circumferential fundamental lamellae. From the age of 48, certain areas of the subperiosteal bone appear hypercalcified, while in others mineral precipitations occur in the inner layer of the periosteum close to the bone cortex, involving the deep periosteal fibers. These periosteal calcifications should partially account for the increase in transverse diameter of bones throughout adult life.

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Section: Discussionmentioning

confidence: 97%

Age Changes in Human Bone: A Microradiographic and Histological Study of Subperiosteal and Periosteal Calcifications

Zagba-Mongalima

Goret-Nicaise²,

Dhem³

1988

Gerontology

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“…This process involves groups of cells functioning as organized units, called "basic multicellular units" (BMUs) by Frost (1963a). This name recognizes that cells do not function independently in adult bone as they may in other biological tissues, but collectively form part of an intermediary organization (Frost, 1985a(Frost, , 1986a) that coordinates and mediates cell-level and tissue-level events in all skeletal tissues.…”

Section: Introductionmentioning

confidence: 99%

Errors in bone remodeling: Toward a unified theory of metabolic bone disease

1989

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Recent evidence suggests that skeletal adaptation is organized by a functional unit that includes cells of diverse origin working in coordination. Genetic and metabolic factors control and regulate the processes of modeling and remodeling, only rarely acting on the isolated individual functions of specific cell lines. Errors in the genetic or metabolic regulation of the functional unit affect the entire process of skeletal adaptation rather than specific elements of it. Viewed in this way, some metabolic bone diseases can be understood as relatively simple errors in factors that control the coordinated activities of the entire functional unit. This paper reviews the modeling and remodeling processes and demonstrates how abnormal morphological characteristics of bone tissue can be viewed as products of specific errors in the adaptive process.

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“…When a remodelling process has just been completed, a small amount of bone (trabecular or cortical) has been removed and has been replaced by new bone. The process seems designed to renew old bone -possibly having microfractures or with dead osteocytes (Frost 1963) -and to reorganize trabecular structures to achieve the maximum strength obtainable with the remaining bone mass (Frost 1983A). The remodelling process has another role: it ensures the maintenance of calcium homeostasis.…”

Section: Remodellingmentioning

confidence: 99%

Dynamics of Bone Remodelling

Mosekilde¹,

Thomsen²,

Mosekilde³

1995

Springer Series in Synergetics

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The skeleton is formed during childhood through the constant influence of daily mechanical loading. Later, the skeleton is remodelled in order to renew bone tissue and reorganise bone structure. Bone remodelling is a dynamic process, with several types of cells working close together in time and space. It occurs in anatomically discrete sites, which are active for a few months and then rest for several years. During each remodelling process, some bone mass is lost, causing the normal age-related bone loss. The bone remodelling process mediates at any time the effect of both hormonal and mechanical agents that act on the skeleton. Different naturally-occurring events or therapeutic regimens can influence the activation frequency, the balance, and all phases of the remodelling process. This dynamic remodelling process can be simulated during normal aging, the menopause, and also during different therapeutic regimens. A simulation model thereby provides "non-invasive" information concerning the influence of the remodelling process on bone mass, architecture, and thereby bone strength -and it also provides a tool for evaluating existing and new regimens for the treatment of osteoporosis.

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Bone Remodelling Dynamics

Cited by 89 publications

References 0 publications

Age Changes in Human Bone: A Microradiographic and Histological Study of Subperiosteal and Periosteal Calcifications

Age Changes in Human Bone: A Microradiographic and Histological Study of Subperiosteal and Periosteal Calcifications

Errors in bone remodeling: Toward a unified theory of metabolic bone disease

Dynamics of Bone Remodelling

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