Bone remodeling regulation under unloading conditions: Numerical investigations

Baïotto, Sébastien; Labat, Béatrice; Vico, Laurence; Zidi, M.

doi:10.1016/j.compbiomed.2008.10.008

Cited by 9 publications

(6 citation statements)

References 25 publications

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“…Continuing work to identify whether the extent of the network varies across species, including extinct species, may also provide insights into how this network complexity has evolved [68][69][70][71]. Finally, as mathematical models of the biomechanical regulation of the skeleton become more comprehensive [49,[72][73][74][75][76][77][78][79][80][81], valid quantifications of the osteocyte network from the cellular to the whole organ scale will allow realistic predictions of this complex dynamic system and its emergent behaviours [82,83]. High-resolution 3D imaging of bone is improving, thus revealing new understandings of the function of the osteocyte network.…”

Section: Discussionmentioning

confidence: 99%

Quantifying the osteocyte network in the human skeleton

Buenzli

Sims

2015

Bone

243

194

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Section: Discussionmentioning

confidence: 99%

Quantifying the osteocyte network in the human skeleton

Buenzli

Sims

2015

Bone

243

194

View full text Add to dashboard Cite

“…That is, in the infrequent walking, the number of loading cycles per day decreased from the daily-loading condition (Table 2) while the same loading forces were applied to the femur; in the cane-assisted walking, the numbers of loading cycles per day remained unchanged but the loading forces were reduced according to the leaning force from the daily-loading condition. * The interval with no loading is embedded into the daily loading condition as unloading (14) .…”

Section: Finite Element Model Of Human Proximal Femurmentioning

confidence: 99%

“…In postmenopausal woman, the statistics analysis showed the correlation between body mass index and osteoporosis (10), (11) . The experimental and simulation results showed that tail suspension induces reduced bone formation in rat tibiae (12) ~ (14) . Furthermore, the predominant effect of unloading was found to be the down-regulation of osteoblast activity possibly with the up-regulation of osteoclast activity in canine studies (15) ~ (16) .…”

Section: Introductionmentioning

confidence: 96%

Computational Study on Trabecular Bone Remodeling in Human Femur under Reduced Weight-bearing Conditions

Kwon

Naito

Matsumoto

et al. 2010

JBSE

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Trabecular bone structure is determined by a balance between osteoblastic bone formation and osteoclastic bone resorption, which is regulated partly by osteocytes according to their mechanical environments. There have been a number of studies on bone remodeling in response to mechanical stimuli, mainly in the physiological range. This study uses a mathematical model previously formulated for surface remodeling available even for disuse and overuse ranges considering osteocyte apoptosis and targeted remodeling. Thus, the present model allows exhibiting the changes of trabecular bone structure under, below, and beyond the daily loading condition. In this study, we carried out computer simulation of bone remodeling in human femur under normal daily loading condition and reduced weight-bearing conditions (infrequent and cane-assisted walking conditions). Decreased trabecular bone with reducing loading condition was shown, and the trabecular bone structure at various degrees of disuse was consistent to Singh Index for osteoporosis diagnosis.

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“…Mathematical models have been utilized by a number of researchers to improve our understanding of complicated biological processes, including bone remodelling, based on fragmented experimental data [4,[19][20][21][22][23][24][25][26][27][28]. These studies have indeed obtained many useful findings and demonstrated that mathematical modelling is an effective way to investigate complicated biological processes.…”

Section: Introductionmentioning

confidence: 99%

Mathematical modelling of bone remodelling cycles including the NFκB signalling pathway

Zhang

Zhen

et al. 2019

Computers in Biology and Medicine

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RANKL can promote the differentiation of osteoclast precursors into mature osteoclasts by binding to RANK expressed on the surfaces of osteoclast progenitor cells during bone remodelling. The NF-B signalling pathway is downstream of RANKL and transmits the RANKL signal to nuclear promoter-bound protein complexes from cell surface receptors, which then regulates target gene expression to facilitate osteoclastogenesis. However, this important role of the NF-B signalling pathway is usually ignored in published mathematical models of bone remodelling. This paper describes the construction of a mathematical model of bone remodelling in a normal bone microenvironment with inclusion of the NF-B signalling pathway. The model consisted of a set of ordinary differential equations and reconstructed variations in the bone cells, resultant bone volume, and biochemical factors involved in the NF-B signalling pathway over time. The model was used to investigate how the NF-B pathway is activated in osteoclast precursors to promote osteoclastogenesis during bone remodelling. Model simulations agreed well with published experimental data. It is hoped that this model can improve our understanding of bone remodelling. It has the obvious potential to examine the influence of NF-B dysregulation on bone remodelling, and even propose potential therapeutic strategies to combat related bone diseases in future research.

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Bone remodeling regulation under unloading conditions: Numerical investigations

Cited by 9 publications

References 25 publications

Quantifying the osteocyte network in the human skeleton

Quantifying the osteocyte network in the human skeleton

Computational Study on Trabecular Bone Remodeling in Human Femur under Reduced Weight-bearing Conditions

Mathematical modelling of bone remodelling cycles including the NFκB signalling pathway

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