Bone Regenerative Biomaterials in Periapical Surgery

Abstract

Introduction: Successful treatment in the endodontics and periodontics depends on the periapical status. Hence, in the present meta-analysis, we evaluate the various bone regenerative materials in the periapical surgeries. Materials and Methods: Online data were collected from the search engines of EBSCO, PubMed, Google Scholar, and Scopus. The searched terms were bone regenerative, bone grafts, bio materials, periapical surgery, and endodontic surgery. Based on the PRISMA guidelines, the meta-analysis was performed. The studies for the past 10 years were considered that included at least 10 patients. The translatable articles were included that had the human studies that were clinical studies and/or trials and also had the bone regenerative materials used in the procedure. Results: A total of 475 articles were selected, of which 30 were selected based on the criteria. Of these, after the removal of the 21 duplicate articles, 9 articles were finalized. The meta-analysis showed that when the bone graft materials are used along with the barriers for the regeneration, there were observed higher success rates. Conclusions: The bone regenerative materials can be used for the successful outcome for the periapical surgeries. The guided tissue regeneration along with the bone regenerative materials may aid in the good prognosis of the endodontic and periodontal cases.

Treatment-Related Factors Affecting the Success of Endodontic Microsurgery and the Influence of GTR on Radiographic Healing—A Cone-Beam Computed Tomography Study

“…Some studies [17,39,40] showed no beneficial effect regarding the rate of healing of such defects, which is in line with the current results. The application of bone grafts and membranes in these cases has even been criticized as an unnecessary cost [39]. On the other hand, Torres et al [41] and Dominiak et al [42] demonstrated that the combined GTR technique allows for a greater success rate in four-wall defects.…”

“…In previous studies [17,[39][40][41][42], there was no consensus on the use of GTR in four-wall defects. Some studies [17,39,40] showed no beneficial effect regarding the rate of healing of such defects, which is in line with the current results. The application of bone grafts and membranes in these cases has even been criticized as an unnecessary cost [39].…”

Assessment of Postoperative Edema in Different Bone Graft Cases in Vertical Defects in Periodontal Surgery: An Original Research

“…This study standardized surgical methods to minimize confounding factors and focus on graft materials and postoperative edema. [ 8 9 10 11 ]…”

Microsurgical management of radicular cyst using guided tissue regeneration technique: A case report

“…The determinants of the success of GTR are the type of bone regenerative biomaterial and the barriers applied. In a systematic review and meta-analysis, Sumangali et al [ 19 ] analyzed the success of GTR in periapical surgeries based on clinical, histological, and radiographic evaluations with different materials, and reported that the use of xenograft in combination with collagen membrane produced a superior result. In the present case, in order to improve the healing of the periapical tissue and avoid tissue collapse due to bone defect, a resorbable type I bovine collagen membrane was used to cover the particulate bovine xenograft after the enucleation of the cyst and the apicoectomy.…”