Bone regeneration with glass ceramic implants and calcium phosphate cements in a rabbit cranial defect model

Schneider, G; Blechschmidt, K.; Linde, Dirk; Litschko, P.; Körbs, Thomas; Beleites, E.

doi:10.1007/s10856-010-4143-0

Cited by 31 publications

(23 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, the implants made of hardened BoneSource TM (an apatite cement) were partly resorbed and replaced by natural bone, depending upon the size of the cranial defect [103]. Replacement of BoneSource TM by bone with a minimal invasion of connective tissue was detected in another study, while ChronOS™ Inject (a brushite cement) samples exhibited a higher rate of connective tissue formation and an insufficient osseointegration [360]. α-BSM ® was evaluated in a canine femoral slot model.…”

Section: Bioresorption and Replacement Of The Self-setting Formulatiomentioning

confidence: 99%

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Dorozhkin¹

2012

IJMC

View full text Add to dashboard Cite

In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are a bioactive and biodegradable grafting material in the form of a powder and a liquid. Both phases after mixing form a viscous paste that after being implanted sets and hardens within the body as either a non-stoichiometric calcium deficient hydroxyapatite (CDHA) or brushite, sometimes blended with un-reacted particles and other phases. As both CDHA and brushite are remarkably biocompartible and bioresorbable (therefore, in vivo they can be replaced with a newly forming bone), self-setting calcium orthophosphate cements represent a good correction technique of non-weight-bearing bone fractures or defects and appear to be very promising materials for bone grafting applications. Besides, these cements possess an excellent osteoconductivity, molding capabilities, and easy manipulation. Nearly perfect adaptation to the tissue surfaces in bone defects and a gradual bioresorption followed by new bone formation are additional distinctive advantages of calcium orthophosphate cements. Besides, reinforced formulations are available; those are described as calcium orthophosphate concretes. Furthermore, formulations with high viscosity, such as pastes and putties are also known. The discovery of self-setting formulations has opened up a new era in the medical application of calcium orthophosphates; several commercial compositions have already been introduced as a result. Many more formulations are in experimental stages. In this review, an insight into the self-setting calcium orthophosphate formulations, as excellent biomaterials suitable for both dental and bone grafting applications, has been provided.

show abstract

Section: Bioresorption and Replacement Of The Self-setting Formulatiomentioning

confidence: 99%

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Dorozhkin¹

2012

IJMC

View full text Add to dashboard Cite

show abstract

“…8 mm); (d) specific functionalizations of a middle ear prosthesis with a mesoporous silica coating, which is used for a site-specific attachment of a growth factor and for local drug delivery. [21][22][23][24][25] A typical middle ear prosthesis made from this material is shown in Fig. 1c.…”

Section: Thomas Lenarzmentioning

confidence: 99%

Mesoporous silica films as a novel biomaterial: applications in the middle ear

et al. 2013

View full text Add to dashboard Cite

In this tutorial review we present the process of the development of functional implants using mesoporous silica. The different steps from chemical synthesis and physicochemical characterization followed by in vitro testing in cell culture assays to clinically relevant in vivo animal studies are examined. Since the end of the 1990s, mesoporous silicas have been considered as biomaterials. Numerous investigations have demonstrated their non-toxic and biocompatible properties. These qualities in combination with the unique properties of high surface area and pore volume, uniform and tunable pore sizes and chemical modifiability are the reasons for the great scientific interest in this field. Here we show that besides bulk materials or mesoporous silica nanoparticles, mesoporous silica films are highly promising as coatings on medical prostheses or implants. We report on the development of functionalized mesoporous silica materials specifically for middle ear applications. Middle ear prostheses are used to restore the sound transmission through this air-filled cavity when the small bones of the middle air (the ossicular chain) have been destroyed by disease or by accidents. In addition to optimal restoration of sound transmission, this technique bears several challenges, e.g. an ongoing bacterial infection or the displacement of the prosthesis due to insufficient fixation. To improve the healing process, a mesoporous silica coating was established on ceramic middle ear prostheses, which then served as a base for further functionalizations. For example, the bone growth factor BMP2 was locally attached to the coating in order to improve the fixation of the prosthesis by forming a bony connection to the remainder of the ear bones. Further, an implant-based local drug delivery system for the antibiotic ciprofloxacin was developed with the aim of fighting bacterial infections. Further possibilities using mesoporous silica nanoparticles as part of a composite on an implant are briefly discussed. Key learning pointsThe way from clinical problems to improved implant materials: materials development, in vitro and in vivo testing. Establishment of mesoporous thin silica films on ceramic surfaces. Degradation of mesoporous silica films in physiological medium. Implant-carried mesoporous silica films as drug delivery systems. Implant-based delivery of biomolecules using mesoporous silica coatings.

show abstract

“…Namely, the implants made of hardened BoneSource TM (an apatite-forming formulation) were found to be partly resorbed and replaced by natural bone, depending upon the size of the cranial defect [127]. Replacement of BoneSource TM by bone with a minimal invasion of connective tissue was detected in another study, while ChronOS TM Inject (a brushite-forming formulation) samples exhibited a higher rate of connective tissue formation and an insufficient osseointegration [406]. α-BSM ® was evaluated in a canine femoral slot model.…”

Section: Bioresorption and Replacement Of The Self-setting Formulatiomentioning

confidence: 99%

Self-Setting Calcium Orthophosphate Formulations

Dorozhkin¹

2012

Calcium Orthophosphates

View full text Add to dashboard Cite

Abstract:In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are bioactive and biodegradable grafting bioceramics in the form of a powder and a liquid. After mixing, both phases form pastes, which set and harden forming either a non-stoichiometric calcium deficient hydroxyapatite or brushite. Since both of them are remarkably biocompartible, bioresorbable and osteoconductive, self-setting calcium orthophosphate formulations appear to be promising bioceramics for bone grafting. Furthermore, such formulations possess excellent molding capabilities, easy manipulation and nearly perfect adaptation to the complex shapes of bone defects, followed by gradual bioresorption and new bone formation. In addition, reinforced formulations have been introduced, which might be described as calcium orthophosphate concretes. The discovery of self-setting properties opened up a new era in the medical application of calcium orthophosphates and many commercial trademarks have been introduced as a result. Currently such formulations are widely used as synthetic bone grafts, with several advantages, such as pourability and injectability. Moreover, their low-temperature setting reactions and intrinsic porosity allow loading by drugs, biomolecules and even cells for tissue engineering purposes. In this review, an insight into the self-setting calcium orthophosphate formulations, as excellent bioceramics suitable for both dental and bone grafting applications, has been provided.

show abstract

Bone regeneration with glass ceramic implants and calcium phosphate cements in a rabbit cranial defect model

Cited by 31 publications

References 22 publications

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Mesoporous silica films as a novel biomaterial: applications in the middle ear

Self-Setting Calcium Orthophosphate Formulations

Contact Info

Product

Resources

About