Bone Regeneration with Calcium Sulfate: Evidence for Increased Angiogenesis in Rabbits

Strocchi, R.; Orsini, Giovanna; Iezzi, Giovanna; Scarano, Antônio; Rubini, Corrado; Pecora, Gabriele; Piattelli, Adriano

doi:10.1563/1548-1336(2002)028<0273:brwcse>2.3.co;2

Cited by 98 publications

(94 citation statements)

References 15 publications

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“…crearon defectos óseos en la tibia de conejos, que fueron llenados con gránulos SC o hueso autógeno, la densidad microvascular se incrementó en los defectos tratados con SC, lo que sugiere un efecto positivo sobre la angiogénesis necesaria para promover la regeneración ósea (1) . En el campo odontológico los investigadores Lebourg y Biou en 1961, implantaron sulfato de calcio en alvéolos después de la extracción de terceros molares inconclusos, así como en los otros defectos óseos en la mandíbula y maxilar.…”

Section: Propiedades Regenerativasunclassified

“…Tiene una historia más larga de uso clínico que la mayoría de los biomateriales disponibles en la actualidad y es ampliamente reconocido como un material bien tolerado, con aplicaciones en la regeneración ósea. Sufre casi reabsorción completa en vivo, sin provocar una significativa respuesta inflamatoria, una propiedad deseable compartida por unos pocos materiales sustitutos óseos (1) . La materia prima de la que se hace es relativamente barata y abundante, se puede combinar con otros materiales como autoinjertos, aloinjertos, fosfatos de calcio, y vidrios bioactivos, para aumentar sus propiedades de unión, el volumen y la eficacia de los injertos óseos.…”

Section: Introductionunclassified

“…La materia prima de la que se hace es relativamente barata y abundante, se puede combinar con otros materiales como autoinjertos, aloinjertos, fosfatos de calcio, y vidrios bioactivos, para aumentar sus propiedades de unión, el volumen y la eficacia de los injertos óseos. También ha servido como un material de vehículo excelente para los factores de crecimiento y múltiples drogas, a pesar de estas ventajas, el material no ha gozado de la popularidad de muchos otros materiales de regeneración, aunque recientemente ha recibido una atención renovada con propiedades hemostáticas, angiogénicas y de barrera o membrana para la preservación de rebordes alveolares postexodoncias (1)(2)(3)(4)(5)(6)(7)(8) . …”

Section: Introductionunclassified

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Sulfato de calcio: propiedades y aplicaciones clínicas

Lopez

Alarcón

2011

Rev. Clin. Periodoncia Implantol. Rehabil. Oral

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RESUMENDurante más de cien años el sulfato de calcio se ha distinguido de otros biomateriales, por ser uno de los materiales aloplásticos más simples y que presenta la más larga historia clínica como material sintético. Entre sus principales propiedades destacan que es de fácil obtención, capacidad de osteoconducción, es totalmente absorbible, no provoca reacciones de inflamación o antigénicas, fácil modelado y fuerza de compresión semejante al tejido óseo. Todas éstas características son necesarias para ser usado como sustituto óseo. Sin embargo, diferencias en la morfología y estructura de sus cristales, la porosidad, propiedades mecánicas y en la constitución química del sulfato de calcio puede alterar significativamente sus propiedades biológicas. El objetivo de la presente revisión es conocer las propiedades del sulfato de calcio y sus diferentes aplicaciones clínicas como sustituto óseo en procedimientos regenerativos. Rev. Clin. Periodoncia Implantol. Rehabil. Oral Vol. 4(3); 138-143, 2011.Palabras clave: Preservación del reborde, exodoncia, implantes dentales, injerto óseo, regeneración. ABSTRACTFor over 100 years, the calcium sulfate has stood out from other biomaterials, for being one of the simplest alloplastic materials and having the longest history as synthetic material. It is readily available, has osteoconductive properties, is completely absorbed, does not cause inflammation or antigenic reactions, can be modeled to defect, has compressive strength similar to bone tissue and can be used as a vehicle for in situ release of chemotherapeutic agents. All these features are required to be used as a bone substitute. However, differences in morphology, crystal structure, porosity, mechanical properties and chemical constitution of calcium sulfate can significantly alter its biological properties. The aim of this study was to determine through a review of the literature, the properties of calcium sulfate and its various clinical applications as bone substitute in regenerative procedures.

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Section: Propiedades Regenerativasunclassified

Section: Introductionunclassified

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Sulfato de calcio: propiedades y aplicaciones clínicas

Lopez

Alarcón

2011

Rev. Clin. Periodoncia Implantol. Rehabil. Oral

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“…They may be injected into vertebral bodies, and because the size of their trabecular structure is similar to human bone, they are gradually resorbed and replaced by native bone over time [52,97]. The calcium sulfate and tri-calcium phosphate classes are more resorbable than bone cements such as polymethylmethacrylate, but will still lead to mechanical protection for a period of years.…”

Section: Future Interventionsmentioning

confidence: 99%

The aging spine: new technologies and therapeutics for the osteoporotic spine

et al. 2003

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IntroductionOsteoporosis is a serious problem in the United States, affecting as many as 13-18% of women and 3-6% of men [49, 55,64,68,89]. If untreated, it is estimated that more than half of all Caucasian white women will sustain an osteoporotic fracture during their lifetime [16,89]. Approximately one-half of these fractures are related to the vertebral bodies, with two-thirds being silent and one-third symptomatic. Epidemiological studies have demonstrated that multiple vertebral fractures increase morbidity [67,69], and the presence and increasing numbers of fractures significantly increase mortality rates [11, 23, 41, 48]. Despite the recognition that osteoporotic fractures increase the risk for additional vertebral fractures as well as hip fractures, the majority of individuals with these fractures remain undiagnosed and untreated [28, 31,74].Over the last ten years, great strides have been made in understanding the pathophysiology of osteoporotic vertebral fractures. Radiographic methods have been enhanced to aid in the diagnosis of osteoporosis. New therapeutics have been developed that may decrease the fragility fracture rate by up to 50% compared with controls treated only with calcium [7, 24, 40,70,79]. During the same time period, two minimally invasive procedures have been developed to rapidly address painful vertebral fractures -vertebroplasty and kyphoplasty. Details regarding these procedures are the subject of separate articles within this issue. Fracture etiology: factor of riskVertebral bodies sustain fractures under two different mechanical environments: repetitive loading that fatigues the cancellous bone and leads to the accumulation of microfractures, or single traumatic events may overload the vertebral body and lead to fracture [58]. To understand the etiology of vertebral fracture, information about the loads imposed onto the vertebral body and the load-bearing capacity of the vertebrae at the time of risk need to be quantified. This concept has been defined as the factor of risk, and represents the ratio of the load applied to the bone over the load necessary to cause a fracture [42]. The load Abstract Osteoporosis results in low-energy fractures of the spine. The load necessary to cause a vertebral fracture is determined by the characteristics related to the vertebral body structure, mineral content, and quality of bone. Radiographic techniques centered on dual X-ray absorptiometry (DXA) permit a determination of bone mass and fracture risk. Current medical therapies principally using bisphosphonate and pulsatile PTH profoundly decrease the risk of fracture (50+%). Fall prevention strategies can further decrease the possibility of fracture. A comprehensive approach to osteoporosis can favorably alter the disease.

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“…Biodegradable CaS exhibits an accelerated linear resorption as well as increased bone formation, and is thus, an affective bone substitute in periosteal regions [2]. The swiftly resorbed CaS material is thought to be a biomechanically affective bone substitute that is intrinsically osteocon-ductive and is hypothesized to actively promote osteogenesis [12,[23][24][25][26]28].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Elution Characteristics of Vancomycin in a Composite Calcium Phosphate/Calcium Sulfate Bone Substitute

2012

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Background: Periprosthetic joint infection is a particularly difficult orthopedic problem, complicating a growing number of revision procedures. Joint debridement and systemic antibiotics are the mainstay of treatment, yet difficulty remains in maintaining a minimum inhibitory concentration of antibiotic at the localized site of infection. Study Aims: This study analyzes the elution characteristics of a 40%bwt calcium phosphate-60%bwt calcium sulfate composite, at varying concentrations of vancomycin. Methods: Four groups of varying concentrations of vancomycin (2.63%bwt, 5.13%, 9.76%, and 17.78%) were mixed with one pack of the composite cement. At designated time intervals up to 28 days, the antibiotic concentration was detected using fluorescence polarization immunoassay and the elution trends compared. Results: The elution rate of each of the four groups decreased over time. At almost all of the intervals, the elution rates of the higher concentration groups were significantly higher than the lower concentration groups (P<0.05). Conclusions: Calcium sulfate reabsorbs over a prolonged period, producing porosity which allows for new bone ingrowth through occupation of osteoprogenitor cells and osteoblasts; while calcium phosphate acts as a long-term osteoconductive matrix. Clinical Relevance: The results of this study suggest that vancomycin can be mixed affectively with a calcium sulfate/ phosphate composite, both maintaining stability and eluting gradually over a clinically relevant period of time.

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Bone Regeneration with Calcium Sulfate: Evidence for Increased Angiogenesis in Rabbits

Cited by 98 publications

References 15 publications

Sulfato de calcio: propiedades y aplicaciones clínicas

Sulfato de calcio: propiedades y aplicaciones clínicas

The aging spine: new technologies and therapeutics for the osteoporotic spine

In Vitro Elution Characteristics of Vancomycin in a Composite Calcium Phosphate/Calcium Sulfate Bone Substitute

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