Bone Regeneration Using Bone Morphogenetic Proteins and Various Biomaterial Carriers

Sheikh, Zeeshan; Javaid, Muhammad; Hamdan, Nader; Hashmi, Raheel M.

doi:10.3390/ma8041778

Cited by 87 publications

(76 citation statements)

References 317 publications

(318 reference statements)

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“…Bone healing is a complex process coordinated through growth factor signaling [21][22][23][24][25] , and tissue engineers use these factors to improve bone healing in bone-mimetic scaffolds 19,20 . Bone morphogenic protein 2 (BMP2) 20,42 , vascular endothelial growth factor (VEGF) 20 , and platelet derived growth factor (PDGF) 34 are popular candidates for use in bone biomaterials. In this manuscript, we described the use of modified simulated body fluid (mSBF) and sequential sequestrations to incorporate BMP2 and VEGF into mineralized collagen scaffolds.…”

Section: Discussionmentioning

confidence: 99%

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Sequential sequestrations increase the incorporation and retention of multiple growth factors in mineralized collagen scaffolds

Tiffany

Dewey

Harley

2020

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Trauma induced injuries of the mouth, jaw, face, and related structures present unique clinical challenges due to their large size and complex geometry. Growth factor signaling coordinates the behavior of multiple cell types following an injury, and effective coordination of growth factor availability within a biomaterial can be critical for accelerating bone healing. Mineralized collagen scaffolds are a class of degradable biomaterial whose biophysical and compositional parameters can be adjusted to facilitate cell invasion and tissue remodeling. Here we describe the use of modified simulated body fluid treatments to enable sequential sequestration of bone morphogenic protein 2 and vascular endothelial growth factor into mineralized collagen scaffolds for bone repair. We report the capability of these scaffolds to sequester growth factors from solution without additional crosslinking treatments and show high levels of retention for individual and multiple growth factors that can be layered into the material via sequential sequestration steps. Sequentially sequestering growth factors allows prolonged release of growth factors in vitro and suggests the potential to improve healing of large-scale bone injury models in vivo. Future work will utilize this sequestration method to induce cellular activities critical to bone healing such as vessel formation and cell migration.

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Section: Discussionmentioning

confidence: 99%

“…Incorporating BMP2 into scaffolds for bone repair is very common and has shown to improve osteogenesis in multiple systems [36][37][38][39][40][41][42] . However, the need for doses of soluble BMP2 larger than what's normally found in the body has led to complications such as abnormal bone formation 43,44 .…”

Section: Introductionmentioning

confidence: 99%

Sequential sequestrations increase the incorporation and retention of multiple growth factors in mineralized collagen scaffolds

Tiffany

Dewey

Harley

2020

Preprint

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“…BMP use has shown promising results for intraoral applications such as sinus augmentation and alveolar ridge preservation [233–237]. The most commonly used and investigated BMPs for bone regeneration applications are BMP-2 & 7 [238].…”

Section: Other Strategies For Periodontal Regenerationmentioning

confidence: 99%

Natural graft tissues and synthetic biomaterials for periodontal and alveolar bone reconstructive applications: a review

et al. 2017

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Periodontal disease is categorized by the destruction of periodontal tissues. Over the years, there have been several clinical techniques and material options that been investigated for periodontal defect repair/regeneration. The development of improved biomaterials for periodontal tissue engineering has significantly improved the available treatment options and their clinical results. Bone replacement graft materials, barrier membranes, various growth factors and combination of these have been used. The available bone tissue replacement materials commonly used include autografts, allografts, xenografts and alloplasts. These graft materials mostly function as osteogenic, osteoinductive and/or osteoconductive scaffolds. Polymers (natural and synthetic) are more widely used as a barrier material in guided tissue regeneration (GTR) and guided bone regeneration (GBR) applications. They work on the principle of epithelial cell exclusion to allow periodontal ligament and alveolar bone cells to repopulate the defect before the normally faster epithelial cells. However, in an attempt to overcome complications related to the epithelial down-growth and/or collapse of the non-rigid barrier membrane and to maintain space, clinicians commonly use a combination of membranes with hard tissue grafts. This article aims to review various available natural tissues and biomaterial based bone replacement graft and membrane options used in periodontal regeneration applications.

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“…The latter phase is characterized by osteoconduction and a process known as creeping substitution. 89 Osteoinduction involves stimulation of osteoprogenitor cells to differentiate into osteoblasts and then begins formation of new bone. The osteoblast precursors differentiate into mature osteoblasts under the influence of osteoinductors and synthesize new bone during the first weeks.…”

Section: Surgical Debridement and Bone Graftingmentioning

confidence: 99%

Peri-Implantitis: A Review of the Disease and Report of a Case Treated with Allograft to Achieve Bone Regeneration

Rashid¹,

Sheikh²,

Vohra³

et al. 2015

Dent Open J

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Dental implants offer excellent tooth replacement options however; peri-implantitis can limit their clinical success by causing failure. Peri-implantitis is an inflammatory process around dental implants resulting in bone loss in association with bleeding and suppuration. Dental plaque is at the center of its etiology, and in addition, systemic diseases, smoking, and parafunctional habits are also implicated. The pathogenic species associated with peri-implantitis include, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Tannerella forsythia. The goal in the management of peri-implantitis is the complete resolution of peri-implant infection with function. Therapies using various biomaterials to deliver antibiotics have been used in the treatment of peri-implantitis e.g. fibers, gels, and beads. The use of guided tissue regeneration barrier membranes loaded with antimicrobials has shown success in re-osseointegrating the infected implants in animal models. Several uncertainties still remain regarding the management of peri-implantitis. The purpose of this article is to present a background of peri-implantitis along with a case of peri-implantitis successfully treated for bone regeneration.

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Bone Regeneration Using Bone Morphogenetic Proteins and Various Biomaterial Carriers

Cited by 87 publications

References 317 publications

Sequential sequestrations increase the incorporation and retention of multiple growth factors in mineralized collagen scaffolds

Sequential sequestrations increase the incorporation and retention of multiple growth factors in mineralized collagen scaffolds

Natural graft tissues and synthetic biomaterials for periodontal and alveolar bone reconstructive applications: a review

Peri-Implantitis: A Review of the Disease and Report of a Case Treated with Allograft to Achieve Bone Regeneration

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