Bone regeneration in mandibular fractures after the application of autologous mesenchymal stem cells, a randomized clinical trial

Castillo-Cardiel, Guadalupe; López-Echaury, Alejandro César; Saucedo-Ortiz, José Antonio; Michel-Espinoza, Luis Rodrigo; Irusteta-Jiménez, Leire; Salazar-Parra, Marcela; González-Ojeda, Alejandro

doi:10.1111/edt.12303

Cited by 39 publications

(26 citation statements)

References 27 publications

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“…Almost all organ system have been implicated in adipose‐derived cell therapy. The indication for treatment in the included studies was (in order count) soft tissue , gastrointestinal , musculoskeletal , rheumatological , ulcer/ischemic limb , urogenital , cardiac , neurological , immunological , pulmonary , and ophthalmological (Fig. A).…”

Section: Resultsmentioning

confidence: 99%

Concise Review: A Safety Assessment of Adipose-Derived Cell Therapy in Clinical Trials: A Systematic Review of Reported Adverse Events

Toyserkani

Jørgensen

Tabatabaeifar

et al. 2017

Stem Cells Translational Medicine

108

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The popularity of adipose‐derived cell therapy has increased over the last decade, and the number of studies published annually is growing. However, concerns regarding safety in the setting of previous malignancy or the use of allogeneic cells have been raised. We therefore aimed to systematically review all clinical studies using adipose‐derived cell therapy to identify reported adverse events with a special focus on risk of thromboembolic, immunological, and oncological safety concerns. Our systematic search resulted in 70 included studies involving more than 1,400 patients that were treated with adipose‐derived cell therapy. Safety assessment method was not described in 32 of the included studies. For studies involving systemic or cardiac administration, one case of pulmonary thromboembolism and cases of both myocardial and cerebral infarctions were described. In the setting of allogeneic cell therapy studies, where the production of specific antibodies toward donor cells was examined, it was noted that 19%–34% of patients develop antibodies, but the consequence of this is unknown. With regard to oncological safety, only one case of breast cancer recurrence was identified out of 121 patients. Adipose‐derived cell therapy has so far shown a favorable safety profile, but safety assessment description has, in general, been of poor quality, and only adverse events that are looked for will be found. We encourage future studies to maintain a strong focus on the safety profile of cell therapy, so its safeness can be confirmed. stem cells translational medicine 2017;6:1786–1794

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Section: Resultsmentioning

confidence: 99%

Concise Review: A Safety Assessment of Adipose-Derived Cell Therapy in Clinical Trials: A Systematic Review of Reported Adverse Events

Toyserkani

Jørgensen

Tabatabaeifar

et al. 2017

Stem Cells Translational Medicine

108

View full text Add to dashboard Cite

show abstract

“…The quality assessment of the included studies revealed an unknown risk of bias (for one or more key domains) for the majority of included studies [4,6,7,9,10-12,33,34], two studies [5,8] was classified as low risk (of bias for all key domains) (Table 1). …”

Section: Resultsmentioning

confidence: 99%

“…In 2016, Castillo-Cardiel et al [5] performed randomized clinical trial on 20 humans to evaluate regeneration time and to increase bone quality by testing effectiveness of AMSCs from adipose tissue application in mandibular angle fractures. Patients were divided into 2 groups while only 1 group the Study Group passes reduction with application of AMSCs, and the Control Group passed only simple fracture reduction.…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, it was demonstrated that human processed lipoaspirate cells, isolated from adipose tissue, could be induced to differentiate into mesenchyme tissue through incubation in specific media and suggesting the applicability of adipose tissue-derived stromal cells (ADSCs) to bone repair, animal studies not only revealed the far greater accessibility of ADSCs, but also the greater number of progenitors in lipoaspirates (100 times more than BMSC for same given volume) [1]. Subsequently, Castillo-Cardiel et al [5] tried to evaluate bone regeneration time and to increase bone quality by testing effectiveness of AMSCs application in human mandibular angle fractures. The result showed that the group who was treated with ADSCs had a 36.48% higher rate of ossification in compare to the group who underwent reduction procedure only.…”

Section: Discussionmentioning

confidence: 99%

“…Two broad categories of cell populations available for bone regeneration include osteoblasts and multipotent cells. Osteoblasts possessing a limited number of divisions, and readily form mineralized matrix and multipotent stem cells have the ability for prolonged division while maintaining the capacity to differentiate along multiple lineages [2] and to improve bone regeneration in large bone defects in animal models [5]. By that considerable attention has received to the use of autologous or allogeneic adult stem cells for tissue repair in humans [6].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Mobilization, Isolation and Characterization of Stem Cells from Peripheral Blood: a Systematic Review

Yosupov¹,

Haimov²,

Juodžbalys³

2017

JOMR

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ObjectivesThe purpose of this article is to systematically review the methods of mobilization, isolation and characterization of stem cells from peripheral blood and to discuss their potential therapeutic applications for bone tissue regeneration.Material and MethodsAn electronic literature search was performed through MEDLINE (PubMed) electronic database. The search was restricted to English language articles published during the last 10 years, from January 2006 to November 2016.ResultsIn total, 37 literature sources were reviewed, and 11 of the most relevant articles that are suitable to the criteria were selected. Articles were analysed with data on animals and humans for mobilization, isolation and characterization of stem cells from peripheral blood. From the examination of selected articles, the mobilization materials, side effects, alternatives and factors affecting the extracted amount of mesenchymal stem cells (MSC) from mobilized peripheral blood of healthy individuals, as well as characterization of mobilized MSC were reviewed in this article.ConclusionsBone tissue engineering is a potential alternative strategy in bone regeneration and bone defect repair, however, insufficiency data display in the literature on potential therapeutic applications of peripheral blood stem cells for bone tissue regeneration.

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Stem Cells and Their Application in Orthopedics

Li¹,

Zhu²,

Sun³

et al. 2022

Biofabrication for Orthopedics

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Bone regeneration in mandibular fractures after the application of autologous mesenchymal stem cells, a randomized clinical trial

Abstract: Similar ossification values were obtained after 4 weeks when the use of AMSCs was compared to simple fracture reduction. However, after 12 weeks, the AMSCs group had a 36.48% higher ossification rate.

Cited by 39 publications

References 27 publications

Concise Review: A Safety Assessment of Adipose-Derived Cell Therapy in Clinical Trials: A Systematic Review of Reported Adverse Events

Concise Review: A Safety Assessment of Adipose-Derived Cell Therapy in Clinical Trials: A Systematic Review of Reported Adverse Events

Mobilization, Isolation and Characterization of Stem Cells from Peripheral Blood: a Systematic Review

Stem Cells and Their Application in Orthopedics

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