Bone regeneration in animals and in man

Eitel, F.; Klapp, F; Jacobson, W.; Schweiberer, L.

doi:10.1007/bf00400911

Cited by 66 publications

(18 citation statements)

References 5 publications

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“…[49][50][51][52][53] Compared with rodents, 54 which have been used in similar investigations, 31,55-58 the vascular pattern, secondary bone structure and metabolic activity index of dogs are more comparable with those of man. 54 Our findings concerning the cartilage and joint surface may not be applied directly to man because of basic differences in the mechanical properties of the articular cartilage.…”

Section: Discussionmentioning

confidence: 99%

Influence of extracorporeal irradiation on the reintegration of autologous grafts of bone and joint

Sabo¹,

Brocai

Eble

et al. 2000

The Journal of Bone and Joint Surgery. British volume

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We studied the effects of irradiation on the reintegration of autologous osteoarticular grafts over a period of 24 weeks in a canine model. In 16 foxhounds the medial femoral condyle was resected, irradiated and immediately replanted. In the control group resection and replantation were performed without irradiation. Reintegration was assessed by macroscopic analysis, histology, radiography and gait analysis.Reintegration was equal at 12 weeks, but significantly inferior in the irradiated group after 24 weeks with delayed bone remodelling. The articular cartilage showed modest degeneration. Conventional radiography and histology showed corresponding changes. Limb function was adequate but the gait was inferior in the treated group.J Bone Joint Surg [Br] 1999;81-B:276-82.

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Section: Discussionmentioning

confidence: 99%

Influence of extracorporeal irradiation on the reintegration of autologous grafts of bone and joint

Sabo¹,

Brocai

Eble

et al. 2000

The Journal of Bone and Joint Surgery. British volume

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“…PTH has not previously been evaluated in this canine model. The canine bone structure most closely resembles human bone and the sites for implantation [40–42]. The native PTH(1–84) and PTH(1–34) fragments show equivalent biological activities at equimolar concentrations [43].…”

Section: Discussionmentioning

confidence: 99%

Parathyroid Hormone Treatment Increases Fixation of Orthopedic Implants with Gap Healing: A Biomechanical and Histomorphometric Canine Study of Porous Coated Titanium Alloy Implants in Cancellous Bone

et al. 2011

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Parathyroid hormone (PTH) administered intermittently is a bone-building peptide. In joint replacements, implants are unavoidably surrounded by gaps despite meticulous surgical technique and osseointegration is challenging. We examined the effect of human PTH(1–34) on implant fixation in an experimental gap model. We inserted cylindrical (10 × 6 mm) porous coated titanium alloy implants in a concentric 1-mm gap in normal cancellous bone of proximal tibia in 20 canines. Animals were randomized to treatment with PTH(1–34) 5 μg/kg daily. After 4 weeks, fixation was evaluated by histomorphometry and push-out test. Bone volume was increased significantly in the gap. In the outer gap (500 μm), the bone volume fraction median (interquartile range) was 27% (20–37%) for PTH and 10% (6–14%) for control. In the inner gap, the bone volume fraction was 33% (26–36%) for PTH and 13% (11–18%) for control. At the implant interface, the bone fraction improved with 16% (11–20%) for PTH and 10% (7–12%) (P = 0.07) for control. Mechanical implant fixation was improved for implants exposed to PTH. For PTH, median (interquartile range) shear stiffness was significantly higher (PTH 17.4 [12.7–39.7] MPa/mm and control 8.8 [3.3–12.4] MPa/mm) (P < 0.05). Energy absorption was significantly enhanced for PTH (PTH 781 [595–1,198.5] J/m2 and control 470 [189–596] J/m2). Increased shear strength was observed but was not significant (PTH 3.0 [2.6–4.9] and control 2.0 [0.9–3.0] MPa) (P = 0.08). Results show that PTH has a positive effect on implant fixation in regions where gaps exist in the surrounding bone. With further studies, PTH may potentially be used clinically to enhance tissue integration in these challenging environments.

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“…Sheep have very little cancellous femoral bone after preparation of the canal for insertion of a cemented stem. 20 We accept that the inclusion of cancellous bone in the FE model may have altered the cortical strain values. It has also been recognised that bone cement creeps at different rates in tension and compression.…”

Section: Discussionmentioning

confidence: 99%

The skeletal response to matt and polished cemented femoral stems

Barker

Wang

Yeo

et al. 2000

The Journal of Bone and Joint Surgery. British volume

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We studied the effect of the surface finish of the stem on the transfer of load in the proximal femur in a sheep model of cemented hip arthroplasty. Strain-gauge analysis and corresponding finite-element (FE) analysis were performed to assess the effect of friction and creep at the cement-stem interface.No difference was seen between the matt and polished stems. FE analysis showed that the effects of cement creep and friction at the stem-cement interface on femoral strain were small compared with the effect of inserting a cemented stem.

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Bone regeneration in animals and in man

Cited by 66 publications

References 5 publications

Influence of extracorporeal irradiation on the reintegration of autologous grafts of bone and joint

Influence of extracorporeal irradiation on the reintegration of autologous grafts of bone and joint

Parathyroid Hormone Treatment Increases Fixation of Orthopedic Implants with Gap Healing: A Biomechanical and Histomorphometric Canine Study of Porous Coated Titanium Alloy Implants in Cancellous Bone

The skeletal response to matt and polished cemented femoral stems

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