Bone reactions to nacre injected percutaneously into the vertebrae of sheep

Lamghari, Meriem; Berland, Sophie; Laurent, A.; Huet, H.; Lopez, Évelyne

doi:10.1016/s0142-9612(00)00213-1

Cited by 69 publications

(59 citation statements)

References 21 publications

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“…Sheep vertebrae have been widely used as a model for human vertebrae for in vivo [45] as well as for in vitro [46] experiments. A morphological study showed that similarities between sheep and human vertebrae are strongest in the thoracic and lumbar regions and suggests sheep spines as a good model for the investigation of spinal implants [47].…”

Section: Discussionmentioning

confidence: 99%

Mechanical competence of bone-implant systems can accurately be determined by image-based micro-finite element analyses

et al. 2009

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The precise failure mechanisms of bone implants are still incompletely understood. Micro-computed tomography in combination with finite element analysis appears to be a potent methodology to determine the mechanical stability of bone-implant constructs. To assess this microstructural finite element (µFE) analysis approach, pull-out tests were designed and conducted on ten sheep vertebral bodies into which orthopedic screws were inserted. µFE models of the same bone-implant constructs were then built and solved, using a large-scale linear FE-solver. µFE calculated pull-out strength correlated highly with the experimentally measured pull-out strength (r 2 = 0.87) thereby statistically supporting the µFE approach. These results suggest that bone-implant constructs can be analyzed using µFE in a detailed and unprecedented way. This could potentially facilitate the development of future implant designs leading to novel and improved fracture fixation methods.Keywords Bone-implant competence · Micro-finite element analysis (µFEA) · Bone microstructure · Peri-implant bone quality · Mechanical testing · Pull-out strength

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Section: Discussionmentioning

confidence: 99%

Mechanical competence of bone-implant systems can accurately be determined by image-based micro-finite element analyses

et al. 2009

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“…In the empty cavity after 8 weeks, the bone was organised into concentric rings (B). 8 weeks after injection the nacre powdered has disappeared and been replaced by new formed bone (C) (Lamghari et al, 2001). …”

Section: Biological Action Of Raw Nacrementioning

confidence: 99%

Nacre, a Natural Biomaterial

Rousseau¹

2011

Biomaterials Applications for Nanomedicine

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“…We do not know whether the possible binding of growth factors in nacre is biologically relevant. However, nacre contains water-soluble proteinaceous factors promoting differentiation of vertebrate fibroblasts into osteoblast-like cells in vitro (28) and nacre implanted into artificial bone cavities promoted bone formation and mineralization (29). It was suggested that these effects were due to the diffusion of growth factor-like substances out of nacre.…”

Section: Comparison To Other Proteinsmentioning

confidence: 99%