Bone quality, and the combination and penetration of cement–bone interface

Abstract

To compare the microstructure, bone quality, and the combination and penetration of cement-bone interface in tissue specimens from patients with osteoarthritis (OA) and rheumatoid arthritis (RA).A total of 80 femoral condyle tissue specimens from 20 OA patients (40 condyles) and 20 RA patients (40 condyles) who underwent total knee arthroplasty at the Department of Orthopaedics in Tengzhou Central People's Hospital were collected between January 2017 and September 2017. According to the random number table method, 20 specimens from the OA group were defined as group A, and 20 specimens in the RA group were defined as group B. The bone quality parameters were measured by micro-CT. The remaining 20 specimens in the OA group and the remaining 20 specimens in the RA group were defined as group C and group D, the cement-bone interfaces were established by the self-made bone cement compression device, and were analyzed by micro-CT.Micro-CT measurement revealed that the bone volume fraction (BV/TV), trabecular thickness (Tb.Th), and trabecular number (Tb.N) in group A were significantly higher than those in group B (all P < .05). The bone surface/bone volume (BS/BV), structure model index (SMI), trabecular separation (Tb.Sp), and degree of anisotropy (DA) in group A were significantly lower than those in group B (all P < .05). The penetration depth of bone cement in group D was significantly greater than those in group C via x-ray detection.The bone quality of OA patients is better than that of RA patients, but the combination and penetration of cement-bone interface of RA patients are better than that of OA patients. The findings advance our understanding of knee prosthesis and have important clinical implications, but they require validations in future studies with larger sample sizes.

Three-Dimensional Micro-Computed Tomography of the Adult Mouse Ovary

“…The main limit of ultrasonography, µ-MRI and PC-CT is an insufficient spatial resolution of these instruments, which is in the order of 10-100 µm/pixel; instead, whilst microCT and SR-CT can reach higher resolutions in the range of 0.35-10 µm/pixel, they mainly work when there is a marked contrast generated by differences in tissue radiopacity. For these reasons, it is not surprising that microCT has been extensively used with hard tissues, such as bones (Mussmann et al, 2017;Song et al, 2018) and teeth (Chałas et al, 2017;Batool et al, 2018;Velozo and Albuquerque, 2019), whose histological composition makes them naturally radiopaque to X-rays. On the other hand, its application on soft tissues is often restricted by the need to employ contrast agents that are largely unspecific with a partial capacity to highlight the presence of different structures within organs (Metscher, 2009;Pauwels et al, 2013;de S e Silva et al, 2015;de Bournonville et al, 2019).…”

Cementing technique for total knee arthroplasty in cadavers using a pastry bone cement

“…Again, penetration depth was lower in the periphery, suggesting that applied pressure was stronger centrally than laterally. However, patient-related conditions (e.g., bone density) and differences in the treatment (e.g., pulse lavage, tourniquet, surface drilling, use of laparotomy sponges, and suction) will lead to different penetration depths of the cement in vivo [ 29 ].…”

Simvastatin Retards Cartilage Degradation and Improves Subchondral Bone Microstructure in Osteoarthritis Mice Induced by High-fat Diet

“…Micro-CT analysis of the subchondral bone microstructure is another way to assess the level of detail regarding the pathological changes present in subchondral bone [29]. previously showed that the abnormalities of subchondral bone were present in OA with high bone turnover and subsequent loss of bone mass [8].…”