Bone Morphometry in Alcoholics

Johnell, Olof; Be, Nilsson; Pe, Wiklund

doi:10.1097/00003086-198205000-00038

Cited by 66 publications

(18 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Stronger evidence that ethanol induces osteoclastogenic activity was provided by the observation of increased osteoclastogenesis in bone marrow cell cultures and the bone histomorphometry finding of increased osteoclast perimeter in the ethanol-fed il6 +/+ mice. These results are consistent with histomorphometric measurements by Diez et al (37) and Johnell et al (38) who observed increased resorptive surface and osteoclast number in alcoholic men. However, our data contrast with those of Crilly et al (39), who did not observe a change in osteoclastic parameters in alcoholic men.…”

Section: Tablesupporting

confidence: 92%

Chronic alcohol ingestion induces osteoclastogenesis and bone loss through IL-6 in mice

Dai¹,

Lin²,

Zhang³

et al. 2000

J. Clin. Invest.

136

100

View full text Add to dashboard Cite

Section: Tablesupporting

confidence: 92%

Chronic alcohol ingestion induces osteoclastogenesis and bone loss through IL-6 in mice

Dai¹,

Lin²,

Zhang³

et al. 2000

J. Clin. Invest.

136

100

View full text Add to dashboard Cite

“…Our finding of significant alcoholism-related spinal and femoral bone loss is consistent with most [4,7,8,15,16,18,21,25,26,39,40], but not all [5,19,24] previous studies. There are few published reports relating BMD quantitatively to alcohol-related bone loss.…”

Section: Discussionsupporting

confidence: 90%

“…In the literature, alcohol-related bone loss at various anatomic sites (e.g., lumbar spine, femur, calcaneus, forearm) has been studied with roentgenography [11,39] and BMD measurements using other densitometries [4,5,7,8,16,18,19,24,26,28] and histological or histomorphometric methods (4,8,15,16,21,25,40]. Our finding of significant alcoholism-related spinal and femoral bone loss is consistent with most [4,7,8,15,16,18,21,25,26,39,40], but not all [5,19,24] previous studies.…”

Section: Discussionsupporting

confidence: 78%

Alcoholism-associated spinal and femoral bone loss in abstinent male alcoholics, as measured by dual X-ray absorptiometry

et al. 1992

View full text Add to dashboard Cite

Although alcoholism is a known risk factor for osteoporosis, there are few published reports on alcoholism-associated bone loss. To study alcoholism-associated bone loss, this study used a dual X-ray absorptiometry (DXA) densitometer to measure lumbar and femoral bone mineral density (BMD) in a previously little-studied population: 32 relatively healthy, nonhospitalized, Caucasian, alcoholic men with a period of abstinence longer than that previously studied (median abstinence 4.0 months, range 3 days-36 months). DXA is a new, highly precise densitometric method with many advantages over the methods used in previous studies. The subjects had statistically significant bone loss at three sites: lumbar spine, femoral neck, and Ward's triangle (multiple correction adjusted two-tailed P < 0.008). Compared to the mean BMD of sex-, age-, and race-matched norms, the subjects' average femoral neck, Ward's triangle, and lumbar BMDs were, respectively, 0.56, 0.69, and 0.57 standard deviations (SDs) below the normative values.

show abstract

“…Long-term excessive alcohol intake has been associated with low bone mass in both genders [24][25][26][27][28]. It is also well established that alcohol abuse confers a high risk for fragility fractures, although this risk is more pronounced in men than in women [25,26,28,29].…”

Section: Discussionmentioning

confidence: 99%

The Impact of Lifestyle Factors on Stress Fractures in Female Army Recruits

Lappe

Stegman

Recker

2001

Osteoporosis International

180

126

View full text Add to dashboard Cite

Estimates are that stress fractures during basic training (BT) occur in as many as 14% of US female military recruits. Injuries of this type lead to morbidity ranging from minor pain to serious lifetime disability. Since women are assuming an increasing role in the military, this high risk of stress fracture is of concern. The purpose of this prospective study was to determine factors that predict stress fracture during BT in US Army female recruits. The analysis was part of an investigation using quantitative ultrasound (QUS) to determine risk of stress fracture during BT. Prior to the start of BT, we obtained QUS measurements and asked each subject to complete a risk factor questionnaire. We completed assessments for 3758 recruits who then proceeded to 8 weeks of BT, during which time any diagnosed stress fractures were reported to us by Army clinicians. Stress fractures were confirmed with radiographs. The incidence of stress fracture was 8.5% per 8 weeks. Factors associated with stress fracture include: QUS, age, race, alcohol and tobacco use, weight-bearing exercise, lowest adult weight, corticosteroid use, and, in white women only, use of depo-medroxyprogesterone acetate (DMPA). Women who fractured were older than women who remained fracture-free, and black women were less likely to sustain a fracture than whites and other races. Compared with their non-stress-fracture counterparts, recruits who developed stress fractures were more likely to report current or past smoking, alcoholic drinking of > 10 drinks/week, corticosteroid use and lower adult weight. A history of regular exercise was protective against stress fracture, and a longer history of exercise further decreased the relative risk of fracture. Although current weight was not associated with stress fracture, lowest adult weight was inversely related to the risk of fracture. We conclude that prevention of stress fractures in female military recruits should include a thorough assessment of lifestyle factors such as exercise patterns, alcohol and tobacco habits, and corticosteroid and DMPA use. Assessment of risk factors may be helpful in pinpointing female recruits who should have further evaluation of their bone health or additional preparation, such as gradual increases in physical activity, prior to being exposed to the rigor of BT.

show abstract

Bone Morphometry in Alcoholics

Cited by 66 publications

References 0 publications

Chronic alcohol ingestion induces osteoclastogenesis and bone loss through IL-6 in mice

Chronic alcohol ingestion induces osteoclastogenesis and bone loss through IL-6 in mice

Alcoholism-associated spinal and femoral bone loss in abstinent male alcoholics, as measured by dual X-ray absorptiometry

The Impact of Lifestyle Factors on Stress Fractures in Female Army Recruits

Contact Info

Product

Resources

About