Bone morphogenic protein-2 use in revision total hip arthroplasty with acetabular defects

Nodzo, Scott R.; Boyle, Keely K.; Pavlesen, Sonja; Rachala, Sridhar R.

doi:10.1007/s00264-017-3671-3

Cited by 7 publications

(2 citation statements)

References 30 publications

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“…The technique of bone grafting is frequently utilized in orthopedic surgery to encourage spinal fusion and reconstruct bone defects resulting from a range of factors, including trauma, tumors, or revision arthroplasty [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 ]. Human bone allografts are frequently used to repair skeletal defects, as these induce bone remodeling and prevent early implant subsidence.…”

Section: Introductionmentioning

confidence: 99%

Enhancing Bone Infection Diagnosis with Raman Handheld Spectroscopy: Pathogen Discrimination and Diagnostic Potential

Lindtner,

Wurm,

Pirchner

et al. 2023

IJMS

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Osteomyelitis is a bone disease caused by bacteria that can damage bone. Raman handheld spectroscopy has emerged as a promising diagnostic tool for detecting bone infection and can be used intraoperatively during surgical procedures. This study involved 120 bone samples from 40 patients, with 80 samples infected with either Staphylococcus aureus or Staphylococcus epidermidis. Raman handheld spectroscopy demonstrated successful differentiation between healthy and infected bone samples and between the two types of bacterial pathogens. Raman handheld spectroscopy appears to be a promising diagnostic tool in bone infection and holds the potential to overcome many of the shortcomings of traditional diagnostic procedures. Further research, however, is required to confirm its diagnostic capabilities and consider other factors, such as the limit of pathogen detection and optimal calibration standards.

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Section: Introductionmentioning

confidence: 99%

Enhancing Bone Infection Diagnosis with Raman Handheld Spectroscopy: Pathogen Discrimination and Diagnostic Potential

Lindtner,

Wurm,

Pirchner

et al. 2023

IJMS

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show abstract

“…Bone represents the second most commonly transplanted tissue behind blood [ 1 ]. In orthopedic surgery, the application of human bone allografts is prevalent in promoting spinal fusion and reconstructing bone defects resulting from trauma, tumors, or revision arthroplasty [ 2 , 3 , 4 , 5 , 6 , 7 , 8 ]. Removing loose implants and adjacent fibro cellular membranes is often necessary in the context of hip arthroplasty revision procedures.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Mid-Infrared Handheld and Benchtop Spectrometers to Detect Staphylococcus epidermidis in Bone Grafts

Lindtner,

Wurm,

Kugel

et al. 2023

Bioengineering

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Bone analyses using mid-infrared spectroscopy are gaining popularity, especially with handheld spectrometers that enable on-site testing as long as the data quality meets standards. In order to diagnose Staphylococcus epidermidis in human bone grafts, this study was carried out to compare the effectiveness of the Agilent 4300 Handheld Fourier-transform infrared with the Perkin Elmer Spectrum 100 attenuated-total-reflectance infrared spectroscopy benchtop instrument. The study analyzed 40 non-infected and 10 infected human bone samples with Staphylococcus epidermidis, collecting reflectance data between 650 cm−1 and 4000 cm−1, with a spectral resolution of 2 cm−1 (Agilent 4300 Handheld) and 0.5 cm−1 (Perkin Elmer Spectrum 100). The acquired spectral information was used for spectral and unsupervised classification, such as a principal component analysis. Both methods yielded significant results when using the recommended settings and data analysis strategies, detecting a loss in bone quality due to the infection. MIR spectroscopy provides a valuable diagnostic tool when there is a tissue shortage and time is of the essence. However, it is essential to conduct further research with larger sample sizes to verify its pros and cons thoroughly.

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Is bone morphogenic protein-2 useful in revision total hip arthroplasty with acetabular defects?

Yan

Fang

2017

International Orthopaedics (SICOT)

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Bone morphogenic protein-2 use in revision total hip arthroplasty with acetabular defects

Abstract: rhBMP-2 had modest clinical benefit in the setting of revision THA. Cost of this synthetic biologic versus the added clinical benefit should be carefully considered when being used in the revision hip setting.

Cited by 7 publications

References 30 publications

Enhancing Bone Infection Diagnosis with Raman Handheld Spectroscopy: Pathogen Discrimination and Diagnostic Potential

Enhancing Bone Infection Diagnosis with Raman Handheld Spectroscopy: Pathogen Discrimination and Diagnostic Potential

Comparison of Mid-Infrared Handheld and Benchtop Spectrometers to Detect Staphylococcus epidermidis in Bone Grafts

Is bone morphogenic protein-2 useful in revision total hip arthroplasty with acetabular defects?

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