Bone Morphogenetic Proteins Regulate Interdigital Cell Death in the Avian Embryo

Merino, Ramón; Gañán, Yolanda; Macias, D.; Rodríguez-León, Joaquín; Hurlé, Juan M.

doi:10.1111/j.1749-6632.1999.tb07927.x

Cited by 64 publications

(42 citation statements)

References 75 publications

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“…Both chondrogenesis and apoptosis are induced by local BMPs. BMP pro-apoptotic activity is reported to regulate the expression of members of the msx family of closely related homeobox-containing genes and is finally mediated by caspase activation (Merino et al 1999). These findings indicate that HSP70 may modulate the ability of BMPs to induce apoptosis through an upstream signaling factor present in the early embryos, such as members of the fibroblast growth factor (FGF) and Transforming growth factor beta (TGF-β) families.…”

Section: -3 Overexpression Of Hsp70mentioning

confidence: 87%

“…Given that high HSP70 levels were found to induce BMP4 signaling and repress head formation in this study, we propose that in order for morphogenesis to occur in early development, HSP70 is required to manifest BMP4-mediated apoptosis-inducing activity by regulating downstream genes and/or serving as one component of multiple inductive signals. As BMPs have been shown to regulate interdigital cell death in the avian embryo, the undifferentiated distal mesodermal cells may undergo chondrogenic differentiation or apoptosis depending on whether they are incorporated into the future digital rays or into the interdigital spaces (Merino et al 1999). Both chondrogenesis and apoptosis are induced by local BMPs.…”

Section: -3 Overexpression Of Hsp70mentioning

confidence: 99%

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Stress Protein HSP70 in Fish

Yamashita¹,

Yabu²,

Ojima³

2010

Aqua-BioSci. Monogr. (ABSM)

126

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Stress proteins (heat-shock proteins, HSPs), which comprise an evolutionally wellconserved protein family, are induced in response to a variety of stress conditions and metabolic insults. When cells are subjected to sudden environmental changes, stress proteins are induced and play a central role in cellular homeostasis. A response to sudden adverse environmental changes is referred to as the heat-shock or stress response and is accompanied by a rapid increase in the synthesis of stress proteins. Given the importance of stress proteins in thermal adaptation at the cellular level, we have studied the expression, regulation, and protective functions of the members of the HSP70 stress protein family under normal and stress conditions in a variety of fish species. HSP70/heat-shock cognate protein-70 (HSC70) plays essential roles in the receptor complex formation and activation of Activin/Nodal/transforming growth factor-β and bone morphogenetic protein receptors and facilitates Nodal signaling. In addition, chaperone-mediated autophagy assisted by HSP70/heat-shock cognate (HSC)70 may be responsible for the stress responses in fish cells. HSP70 and HSC70 translocated into the lysosomes were found to accelerate protein degradation and catabolism under both stressed and normal conditions.

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Section: -3 Overexpression Of Hsp70mentioning

confidence: 87%

Section: -3 Overexpression Of Hsp70mentioning

confidence: 99%

Stress Protein HSP70 in Fish

Yamashita¹,

Yabu²,

Ojima³

2010

Aqua-BioSci. Monogr. (ABSM)

126

View full text Add to dashboard Cite

show abstract

“…Interdigital expression of Cyp26a has not been reported in amniotes. Interdigital tissue is selectively removed by apoptosis in chickens, a process that is regulated by BMP7, which in turn is regulated by RA (Merino et al, 1999). Unlike amniotes, the interdigital region in Xenopus limbs does not undergo apoptosis (Cameron and Fallon, 1977).…”

Section: Complex Regulation Of Ra In Later Limb Development Sculpts Tmentioning

confidence: 99%

Expression of key retinoic acid modulating genes suggests active regulation during development and regeneration of the amphibian limb

McEwan

Lynch

Beck

2011

Developmental Dynamics

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We have previously shown differential regulation of components of the Retinoic acid (RA) pathway in Xenopus tadpole hindlimb regeneration. RA is thought to act as a morphogen, providing positional information during development and regeneration. We have investigated the regulation of genes involved in RA synthesis, catabolism, and binding in developing and regenerating Xenopus limbs. Our data indicate that RA is synthesised by Raldh2 in proximal cells during limb bud outgrowth. Furthermore, Cyp26b is expressed transiently in the progress zone of developing limbs and the blastema of regenerating limbs suggesting degradation of RA occurs in both processes. The RA‐binding protein Crabp2 is also upregulated during regeneration. We summarise this data to predict the presence of evolving gradients of RA in the developing amphibian limb. Thus, RA from the stump cells could be responsible for the establishment of proximal‐distal pattern during limb regeneration, as predicted by classical studies. Developmental Dynamics 240:1259–1270, 2011. © 2011 Wiley‐Liss, Inc.

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“…In ducks, interdigital cell death in the webbed foot is correlated with the restriction of Msx2 to the distal edge of the limbs (14). If repression of Bmp targets is a common mechanism to restrict cell death and generate webbed limbs, Msx gene expression in bat wings should reflect this repression and hence be absent or greatly reduced compared with bat hindlimbs.…”

Section: Interdigits (mentioning

confidence: 99%

Interdigital webbing retention in bat wings illustrates genetic changes underlying amniote limb diversification

Weatherbee

Behringer

Rasweiler

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

127

142

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Developmentally regulated programmed cell death sculpts the limbs and other embryonic organs in vertebrates. One intriguing example of species-specific differences in apoptotic extent is observed in the tissue between the digits. In chicks and mice, bone morphogenetic proteins (Bmps) trigger apoptosis of the interdigital mesenchyme, leading to freed digits, whereas in ducks, Bmp antagonists inhibit the apoptotic program, resulting in webbed feet. Here, we show that the phyllostomid bat Carollia perspicillata utilizes a distinct mechanism for maintaining interdigit tissue. We find that bat forelimb and hindlimb interdigital tissues express Bmp signaling components but that only bat hindlimbs undergo interdigital apoptosis. Strikingly, the retention of interdigital webbing in the bat forelimb is correlated with a unique pattern of Fgf8 expression in addition to the Bmp inhibitor Gremlin. By using a functional assay, we show that maintenance of interdigit tissue in the bat wing depends on the combined effects of high levels of Fgf signaling and inhibition of Bmp signaling. Our data also indicate that although there is not a conserved mechanism for maintaining interdigit tissue across amniotes, the expression in the bat forelimb interdigits of Gremlin and Fgf8 suggests that these key molecular changes contributed to the evolution of the bat wing.bone morphogenetic protein ͉ Carollia perspicillata ͉ Fgf ͉ Gremlin

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Bone Morphogenetic Proteins Regulate Interdigital Cell Death in the Avian Embryo

Cited by 64 publications

References 75 publications

Stress Protein HSP70 in Fish

Stress Protein HSP70 in Fish

Expression of key retinoic acid modulating genes suggests active regulation during development and regeneration of the amphibian limb

Interdigital webbing retention in bat wings illustrates genetic changes underlying amniote limb diversification

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