Bone morphogenetic proteins mediate crosstalk between cancer cells and the tumour microenvironment at primary tumours and metastases (Review)

Sun, Zhiwei; Cai, Sanjun; Zabkiewicz, Catherine; Liu, Chang; Ye, Lin

doi:10.3892/ijo.2020.5030

Cited by 8 publications

(7 citation statements)

References 220 publications

(306 reference statements)

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“…MMPs (matrix metalloproteinases) influence tumour invasion and cancer cell migration which can be regulated by BMPs (4,18). ACVRL1, GDF6, BMP8A, ACVR1 and GREM1 were seen as the top five genes which were positively correlated with the MMPs while ACVR1B, ACVR2B, GDF9, DAND5, BMPR1B were ranked as the top five being negatively correlated.…”

Section: Correlation Between Bmps and Epithelial Mesenchymal Transiti...mentioning

confidence: 99%

“…Previous studies have reported that there are over 20 BMP ligands, which are transduced by seven type I and five type II transmembrane serine/threonine kinase receptors (3). They were originally found in bones, playing a critical role in endochondral bone growth, embryonic development, tissue repair and homeostasis and stemness (4). Upon interaction with the BMP ligands, the Type-II receptors phosphorylate the Type-I receptors.…”

Section: Introductionmentioning

confidence: 99%

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Aberrant expression of bone morphogenetic proteins in the disease progression and metastasis of breast cancer

et al. 2023

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BackgroundBone morphogenetic proteins (BMPs) play crucial roles in the tumorigenesis and metastasis of cancers. Controversy remains about the exact implications of BMPs and their antagonists in breast cancer (BC), due to their diverse and complex biological functions and signalling. A comprehensive study of the whole family and their signalling in breast cancer is provoked.MethodsAberrant expression of BMP, BMP receptors and antagonists in primary tumours in breast cancer were analysed by using TCGA-BRCA and E-MTAB-6703 cohorts. Related biomarkers including ER, HER, proliferation, invasion, angiogenesis, lymphangiogenesis and bone metastasis were involved to identify the relationship with BMPs in breast cancer.ResultsThe present study showed BMP8B was significantly increased in breast tumours, while BMP6 and ACVRL1 were decreased in breast cancer tissues. The expressions of BMP2, BMP6, TGFBR1 and GREM1 were significantly correlated with BC patients’ poor overall survival. Aberrant expression of BMPs, together with BMP receptors, were explored in different subtypes of breast cancer according to ER, PR and HER2 status. Furthermore, higher levels of BMP2, BMP6 and GDF5 were revealed in triple negative breast cancer (TNBC) whilst BMP4, GDF15, ACVR1B, ACVR2B and BMPR1B were relatively higher in Luminal type BC. ACVR1B and BMPR1B were positively correlated with ERα but were inversely correlated with ERβ. High expression of GDF15, BMP4 and ACVR1B were associated with poorer overall survival in HER2 positive BC. BMPs also play dual roles in tumour growth and metastasis of BC.ConclusionA shift pattern of BMPs was showed in different subtypes of breast cancer suggesting a subtype specific involvement. It provokes more research to shed light on the exact role of these BMPs and receptors in the disease progression and distant metastasis through a regulation of proliferation, invasion and EMT.

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Section: Correlation Between Bmps and Epithelial Mesenchymal Transiti...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Aberrant expression of bone morphogenetic proteins in the disease progression and metastasis of breast cancer

et al. 2023

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“…The significance of BMP4 in proper PS and mesoderm development has been well documented [20,37], and it is known to be secreted from the amnion during mesoderm induction [50]. However, BMP4 and EGF could be redundant during ExM formation, possibly via the common PI3K/AKT and/or MAPK pathway [97]. Additionally, the two protocols also contain other components with opposing effects.…”

Section: Discussionmentioning

confidence: 99%

Derivation of Human Extraembryonic Mesoderm-like Cells from Primitive Endoderm

Farkas

Ferretti

2023

IJMS

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In vitro modeling of human peri-gastrulation development is a valuable tool for understanding embryogenetic mechanisms. The extraembryonic mesoderm (ExM) is crucial in supporting embryonic development by forming tissues such as the yolk sac, allantois, and chorionic villi. However, the origin of human ExM remains only partially understood. While evidence suggests a primitive endoderm (PrE) origin based on morphological findings, current in vitro models use epiblast-like cells. To address this gap, we developed a protocol to generate ExM-like cells from PrE-like cell line called naïve extraembryonic endoderm (nEnd). We identified the ExM-like cells by specific markers (LUM and ANXA1). Moreover, these in vitro-produced ExM cells displayed angiogenic potential on a soft matrix, mirroring their physiological role in vasculogenesis. By integrating single-cell RNA sequencing (scRNAseq) data, we found that the ExM-like cells clustered with the LUM/ANXA1-rich cell populations of the gastrulating embryo, indicating similarity between in vitro and ex utero cell populations. This study confirms the derivation of ExM from PrE and establishes a cell culture system that can be utilized to investigate ExM during human peri-gastrulation development, both in monolayer cultures and more complex models.

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“…These interactions direct the functions of tumor and stromal cells in the niche to promote the initiation of tumor growth, angiogenesis, local invasion, and metastasis. This leads to the establishment of cancer cells in the tumor niche (Sun et al, 2020). Extracellular antagonists such as chordin, noggin, follistatin, cerberus,g-1, and tolloid, can bind to BMPs and inhibit their interaction with corresponding receptors (Zylbersztejn et al, 2018).…”

Section: Aging and Cancermentioning

confidence: 99%

Targeting the stem cell niche micro-environment as therapeutic strategies in aging

Farahzadi

Valipour²,

Montazersaheb

et al. 2023

Front. Cell Dev. Biol.

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Adult stem cells (ASCs) reside throughout the body and support various tissue. Owing to their self-renewal capacity and differentiation potential, ASCs have the potential to be used in regenerative medicine. Their survival, quiescence, and activation are influenced by specific signals within their microenvironment or niche. In better words, the stem cell function is significantly influenced by various extrinsic signals derived from the niche. The stem cell niche is a complex and dynamic network surrounding stem cells that plays a crucial role in maintaining stemness. Studies on stem cell niche have suggested that aged niche contributes to the decline in stem cell function. Notably, functional loss of stem cells is highly associated with aging and age-related disorders. The stem cell niche is comprised of complex interactions between multiple cell types. Over the years, essential aspects of the stem cell niche have been revealed, including cell-cell contact, extracellular matrix interaction, soluble signaling factors, and biochemical and biophysical signals. Any alteration in the stem cell niche causes cell damage and affects the regenerative properties of the stem cells. A pristine stem cell niche might be essential for the proper functioning of stem cells and the maintenance of tissue homeostasis. In this regard, niche-targeted interventions may alleviate problems associated with aging in stem cell behavior. The purpose of this perspective is to discuss recent findings in the field of stem cell aging, heterogeneity of stem cell niches, and impact of age-related changes on stem cell behavior. We further focused on how the niche affects stem cells in homeostasis, aging, and the progression of malignant diseases. Finally, we detail the therapeutic strategies for tissue repair, with a particular emphasis on aging.

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Bone morphogenetic proteins mediate crosstalk between cancer cells and the tumour microenvironment at primary tumours and metastases (Review)

Cited by 8 publications

References 220 publications

Aberrant expression of bone morphogenetic proteins in the disease progression and metastasis of breast cancer

Aberrant expression of bone morphogenetic proteins in the disease progression and metastasis of breast cancer

Derivation of Human Extraembryonic Mesoderm-like Cells from Primitive Endoderm

Targeting the stem cell niche micro-environment as therapeutic strategies in aging

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