Bone morphogenetic proteins (BMPs) and their role in poultry

Divya, D.; Bhattacharya, T. K.

doi:10.1080/00439339.2021.1959274

Cited by 2 publications

(2 citation statements)

References 196 publications

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“…BMP5, a key member of the TGF-β signaling pathway, is reported to participate in fecundity of animals [ 61 ]. Meanwhile, BMP5 could affect ovary development by TGF-β signaling pathway activation [ 62 ]. BMP2 has been identified as a candidate gene within the hypothalamic-pituitary-gonadal axis responsible for different egg production performance of ducks [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

Pituitary transcriptome profile from laying period to incubation period of Changshun green-shell laying hens

Chen,

Wen,

Zhang

et al. 2024

BMC Genomics

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Background Incubation behaviour, an instinct for natural breeding in poultry, is strictly controlled by the central nervous system and multiple neuroendocrine hormones and neurotransmitters, and is closely associated with the cessation of egg laying. Therefore, it is essential for the commercial poultry industry to clarify the molecular regulation mechanism of incubation behaviour. Here, we used high-throughput sequencing technology to examine the pituitary transcriptome of Changshun green-shell laying hen, a local breed from Guizhou province, China, with strong broodiness, in two reproductive stages, including egg-laying phase (LP) and incubation phase (BP). We also analyze the differences in gene expression during the transition from egg-laying to incubation, and identify critical pathways and candidate genes involved in controlling the incubation behaviour in the pituitary. Results In this study, we demonstrated that a total of 2089 differently expressed genes (DEGs) were identified in the pituitary, including 842 up-regulated and 1247 down-regulated genes. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed that steroid biosynthesis pathway and neuroactive ligand-receptor interaction were significantly enriched based on DEGs commonly identified in pituitary. Further analysis revealed that SRC, ITGB4, ITGB3, PIK3R3 and DRD2 may play crucial roles in the regulation of incubation behaviour. Conclusions We identified 2089 DEGs and the key signaling pathways which may be closely correlated with incubation in Changshun green-shell laying hens, and clarified the molecular regulation mechanism of incubation behaviour. Our results indicate the complexity and variety of differences in reproductive behaviour of different chicken breeds.

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Section: Discussionmentioning

confidence: 99%

Pituitary transcriptome profile from laying period to incubation period of Changshun green-shell laying hens

Chen,

Wen,

Zhang

et al. 2024

BMC Genomics

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“…Among the enrichment pathways, the TGF-beta signaling pathway plays an important role in the growth and maintenance of various tissues with BMP (Miyazono 2000 ; Zuo et al 2017 ). Especially, BMP5 has a role in ovary development by TGF-beta signaling pathway activation (Shimasaki et al 2004 ; Divya and Bhattacharya 2021 ). The SMAD2 is important in the TGF-beta signaling pathway, which could affect the growth of tissues with the female genital.…”

Section: Discussionmentioning

confidence: 99%

Blood transcriptome comparison between sexes and their function in 4-week Rhode Island red chickens

Kim

Choo

Cha

et al. 2022

Animal Cells and Systems

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Sex is a major biological factor in the development and physiology of a sexual reproductive organism, and its role in the growing process is needed to be investigated in various species. We compare blood transcriptome between 5 males and 5 females in 4-week-old Rhode Island Red chickens and perform functional annotation of differentially expressed genes (DEGs). The results are as follows. 141 and 109 DEGs were located in autosomes and sex chromosomes, respectively. The gene ontology (GO) terms are significantly ( p < 0.05) enriched, which were limb development, inner ear development, positive regulation of dendrite development, the KEGG pathway the TGF-beta signaling pathway, and melanogenesis ( p < 0.05). These pathways are related to morphological maintenance and growth of the tissues. In addition, the SMAD2W and the BMP5 were involved in the TGF-beta signaling pathway, and both play an important role in maintaining tissue development. The major DEGs related to the development of neurons and synapses include the up-regulated NRN1 , GDF10 , SLC1A1 , BMP5 , NBEA, and NRXN1 . Also, 7 DEGs were validated using RT-qPCR with high correlation ( r 2 = 0.74). In conclusion, the differential expression of blood tissue in the early growing chicken was enriched in TGF-beta signaling and related to the development of neurons and synapses including SMAD2W and BMP5 . These results suggest that blood in the early growing stage is differentially affected in tissue development, nervous system, and pigmentation by sex. For future research, experimental characterization of DEGs and a holistic investigation of various tissues and growth stages will be required.

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Bone morphogenetic proteins (BMPs) and their role in poultry

Cited by 2 publications

References 196 publications

Pituitary transcriptome profile from laying period to incubation period of Changshun green-shell laying hens

Pituitary transcriptome profile from laying period to incubation period of Changshun green-shell laying hens

Blood transcriptome comparison between sexes and their function in 4-week Rhode Island red chickens

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