Bone morphogenetic protein (BMP)1-3 enhances bone repair

Grgurević, Lovorka; Maček, Boris; Merćep, Mladen; Jelić, Mislav; Smoljanović, Tomislav; Erjavec, Igor; Dumić-Čule, Ivo; Prgomet, Stefan; Đurđević, Dragan; Vnuk, Dražen; Lipar, Marija; Stejskal, Marko; Kufner, Vera; Brkljačić, Jelena; Matičić, Dražen; Vukičević, Slobodan

doi:10.1016/j.bbrc.2011.03.109

Cited by 67 publications

(44 citation statements)

References 27 publications

(24 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recently, mTLD was reported to as a component of human plasma (37), although with a size of 95 kDa, smaller than the 130 kDa previously reported for mTLD (11,23). Thus, mTLD or an mTLD derivative may exert systemic effects, in addition to localized effects exerted by mTLD produced in individual tissues.…”

Section: B/tp Distributions and General Functionsmentioning

confidence: 70%

“…Thus, mTLD or an mTLD derivative may exert systemic effects, in addition to localized effects exerted by mTLD produced in individual tissues. Circulating mTLD appears to be involved in bone fracture repair and in the fibrosis associated with chronic kidney disease (37,39). Thus, inhibition or provision of circulating mTLD may represent future approaches to therapeutic interventions in these and related conditions.…”

Section: B/tp Distributions and General Functionsmentioning

confidence: 99%

See 1 more Smart Citation

Metalloproteinases in Drosophila to Humans That Are Central Players in Developmental Processes

Muir

Greenspan

2011

Journal of Biological Chemistry

View full text Add to dashboard Cite

Many secreted proteins are synthesized as precursors with propeptides that must be cleaved to yield the mature functional form of the molecule. In addition, various growth factors occur in extracellular latent complexes with protein antagonists and are activated upon cleavage of such antagonists. Research in the separate fields of embryonic patterning and extracellular matrix formation has identified members of the BMP1/Tolloid-like family of metalloproteinases as key players in these types of biosynthetic processing events in species ranging from Drosophila to humans. Bone morphogenic proteins (BMPs)2 were first defined by the ability to induce de novo bone formation and were first identified in bone extracts (1). Although all other BMPs are members of the TGF␤ superfamily of growth factors, BMP1 is a metalloproteinase, the first demonstrated role of which was as a procollagen C-proteinase (pCP) (2) that cleaves C-propeptides from procollagen precursors to produce mature monomers of the major fibrillar collagens I-III. This activity is crucial to bone biology, as collagen I is the major protein component of bone and is essential to bone structure/function. After initial cloning of mammalian BMP1, Tolloid (TLD), the protein product of a zygotically active gene involved in dorsoventral patterning of Drosophila embryos, was shown to have a domain structure resembling that of BMP1 (3) and was later shown to exert patterning effects by activating the TGF␤-like BMP decapentaplegic (DPP) (4). Subsequently, BMP1 and TLD have become prototypes of the BMP1/TLD-like proteinase (B/TP) family. B/TPs in a broad range of species are now implicated in processes that include extracellular matrix (ECM) formation and mineralization, embryonic patterning, growth factor activation, and generation of anti-angiogenic protein fragments, all via cleavage of a growing list of substrates.

show abstract

Section: B/tp Distributions and General Functionsmentioning

confidence: 70%

Section: B/tp Distributions and General Functionsmentioning

confidence: 99%

Metalloproteinases in Drosophila to Humans That Are Central Players in Developmental Processes

Muir

Greenspan

2011

Journal of Biological Chemistry

View full text Add to dashboard Cite

show abstract

“…(250 ug/kg, 2x/wk) and BMP1-3 (3 ug, 3x/wk) +BMP6 i.v. (250 μg, 2x/wk) therapy (mean±SD, n=6) [234]. D. Outline of a hypothetical experiment in which tested treatment (T) and a control (Ctr) are assessed ex-vivo at two time points (1, 2) around midtime of the spontaneous healing process.…”

Section: Non-critical Size Defectmentioning

confidence: 99%

The rational use of animal models in the evaluation of novel bone regenerative therapies

Perić¹,

Dumić-Čule²,

Grčević³

et al. 2015

Bone

Self Cite

117

116

View full text Add to dashboard Cite

“…In contrast, injection of specific polyclonal antibody and endogenous BMPs-1-3 led to delayed bone junction. The in vitro experiments found that BMPs-1-3 can enhance the expression levels of type-I collagen and osteocalcin in osteoclasts MC3T3-E1 and stimulate the formation of mineralized bone knot of mesenchymal stem cells [61].…”

Section: Interactions Between Bmp-1 and Bmps Family Membersmentioning

confidence: 99%

Bone morphogenetic proteins: Relationship between molecular structure and their osteogenic activity

Yang

Shi

et al. 2014

Food Science and Human Wellness

View full text Add to dashboard Cite

Please cite this article in press as: J. Yang, et al., Bone morphogenetic proteins: Relationship between molecular structure and their osteogenic activity, Food Sci. Hum. Wellness (2015), http://dx. AbstractBone morphogenetic proteins (BMPs) are a family of potent, multifunctional growth factors belonging to transforming growth factor-␤ (TGF-␤). They are highly conservative in structures. Over 20 members of BMPs with varying functions such as embryogenesis, skeletal formation, hematopoiesis and neurogenesis have been identified in human body. BMPs are unique growth factors that can induce the formation of bone tissue individually. BMPs can induce the differentiation of bone marrow mesenchymal stem cells into osteoblastic lineage and promote the proliferation of osteoblasts and chondrocytes. BMPs stimulate the target cells by specific membrane-bound receptors and signal transduced through mothers against decapentaplegic (Smads) and mitogen activated protein kinase (MAPK) pathways. It has been demonstrated that BMP-2, BMP-4, BMP-6, BMP-7, and BMP-9 play an important role in bone formation. This article focuses on the molecular characterization of BMPs family members, mechanism of osteogenesis promotion, related signal pathways of osteogenic function, relationships between structure and osteogenetic activity, and the interactions among family members at bone formation.

show abstract

Bone morphogenetic protein (BMP)1-3 enhances bone repair

Cited by 67 publications

References 27 publications

Metalloproteinases in Drosophila to Humans That Are Central Players in Developmental Processes

Metalloproteinases in Drosophila to Humans That Are Central Players in Developmental Processes

The rational use of animal models in the evaluation of novel bone regenerative therapies

Bone morphogenetic proteins: Relationship between molecular structure and their osteogenic activity

Contact Info

Product

Resources

About