Bone modeling: biomechanics, molecular mechanisms, and clinical perspectives

Roberts, W. Eugene; Huja, Sarandeep S.; Roberts, Jeffery A.

doi:10.1053/j.sodo.2004.01.003

Cited by 160 publications

(106 citation statements)

References 168 publications

Supporting

Mentioning

101

Contrasting

Unclassified

Order By: Relevance

“…[2][3][4][5][6][7][8][9] The mechanism of bone remodeling can also be related to the release of inflammatory mediators, such as prostaglandin E 2 . [1][2][3][4] Prostaglandin E 2 (PGE 2 ) and interleukin IL-1β are key mediators involved in periodontal diseases, potent stimulators of bone resorption, and are produced by human periodontal ligament cells in response to mechanical stress. PGE 2 not only mediates inflammatory responses, such as increases in vascular permeability and dilatation, but also can act as a potent stimulator of bone resorption and formation.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8][9] The early phase of orthodontic tooth movement involves an acute inflammatory response characterized by local tissue ischemia, periodontal vasodilatation and the migration of leukocytes through the periodontal ligament capillaries. [1][2][3][4][5][6][7][8][9] In this process, endothelial cells are activated, and cytokines and chemoattractants are produced that result in leukocyte activation. The interaction between activated endothelial cells and leukocytes plays an important role in the inflammatory process by producing proinflammatory and anti-inflammatory cytokines.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Juveniles versus adults: differences in PGE2 levels in the gingival crevicular fluid during orthodontic tooth movement

2010

View full text Add to dashboard Cite

Juveniles versus adults: differences in PGE 2 levels in the gingival crevicular fluid during orthodontic tooth movement Abstract: This study aimed to investigate age-related changes in the biosynthetic capacity of prostaglandin E 2 (PGE 2 ) in the gingival crevicular fluid (GCF) during one month of orthodontic treatment. Twentyfive juvenile subjects (mean age 13 ± 2.1 years) and 23 adults (mean age 24 ± 2.1 years) were included. GCF was collected immediately before the force application at the baseline, 2, 21 and 28 days, with periopaper inserted into the gingival crevice of the maxillary lateral incisors. The mediator levels were determined with an EIA kit. The results showed that the PGE 2 concentrations were significantly elevated from the baseline to 21 days (129.35 and 198.84 pg/µL, p = 0.0169) in juvenile subjects and reduced from 21 to 28 days (198.84 to 112.60 pg/µL, p = 0.0032). Adults, however, had no significant changes in the PGE 2 levels. The total amounts of PGE 2 from both groups changed between the baseline to 21 and 21 to 28 days (p = 0.0119 and p = 0.0076, respectively). The PGE 2 initial and final levels showed significant differences between the juveniles and adults, being higher in adults (baseline: juvenile = 129.35 pg/µL vs. adult = 163.20 pg/µL, p = 0.0379; t3: juvenile = 112.60 pg/µL and adult = 175.30 pg/µL, p = 0.0005). In conclusion, the results demonstrate the presence of variation in the PGE 2 levels according to age and the orthodontic activation period, which can explain why the speed of orthodontics treatment may be different in adults vs. juveniles.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Juveniles versus adults: differences in PGE2 levels in the gingival crevicular fluid during orthodontic tooth movement

2010

View full text Add to dashboard Cite

show abstract

“…In context to root resorption and other adverse effects, not much understanding exists in relation to their occurrence and pathogenesis. [8][9][10] Osteoblasts and osteoclasts are the principal cells involved in the bone remodeling process which causes movement of teeth inside the bone. Past studies in the literature have shown that some amount of alteration do occur in the GCF levels of various bone biomarkers (RANKL, OPN) under the influence of active orthodontic treatment.…”

Section: Discussionmentioning

confidence: 99%

Gingival Crevicular Fluid Turnover Markers in Premenopausal vs Postmenopausal Women receiving Orthodontic Treatment

Bitra

et al. 2017

The Journal of Contemporary Dental Practice

View full text Add to dashboard Cite

Background: Orthodontic treatment is one of the commonly used dental treatments. Orthodontic forces act on the bone by modulating the biomolecules, chiefly the osteoprotegerin (OPG), osteopontin (OPN), receptor activator of nuclear factor kappa-B (RANK), and RANK ligand (RANKL) (OPG ligand). Hormonal changes are known to cause marked alteration in the levels of these biomolecules. Hence, we planned this study to evaluate the response of bone biomarkers in the gingival crevicular fluid (GCF) in postmenopausal women undergoing fixed orthodontic therapy. Materials and methods:This study included assessment of 50 subjects who underwent orthodontic treatment from June 2012 to July 2016. All the patients were divided into two study groups with 25 patients in each group: premenopausal group and postmenopausal group. Similar orthodontic wires were used for controlling the forces applied in subjects of both the study groups and their GCF levels of RANKL, and OPN was assessed at baseline and 24 hours after the activation of orthodontic forces. All the results were compiled, assessed, and analyzed by Statistical Package for the Social Sciences software version 16.0. Chi-square test, Student's t-test, and Mann-Whitney U test were used for the assessment of the level of significance. Gingival Crevicular Fluid Turnover Markers in Premenopausal vs Results:The mean values of RANKL and OPN in the premenopausal and postmenopausal groups were found to be 241.52 and 317.15 pg/µL respectively. The mean values of RANKL at baseline in the premenopausal and postmenopausal groups were found to be 7.15 and 3.84 pg/µL respectively. Nonsignificant results were obtained while comparing mean OPN and RANKL level alteration in between the two study groups. Conclusion:The mean alterations in the GCF levels of bone biomarkers are similar for both premenopausal and postmenopausal women.Clinical significance: For women with either premenopausal or postmenopausal status, orthodontic treatment appears to be equally safer.

show abstract

“…The cloth was placed in a corner in the cage. In the control group 3 rats were housed in a cage and were exposed to a clean cloth (20)(21)(22)(23)(24)(25). The rats in both groups received drinking water and standard laboratory food ad libitum during the study period.…”

Section: Methodsmentioning

confidence: 99%

Effect of psychological stress on orthodontic tooth movement in rats

Mirzakouchaki

Firoozi²,

Shahrbaf³

2011

Med Oral

View full text Add to dashboard Cite

Introduction: The purpose of this study was to investigate the effect of psychological stress on orthodontic tooth movement in Wistar rats. Materials and methods: Forty-eight female ten-week old Wistar rats with an average weight of 188 ±12 gr were selected and randomly divided into two experimental and control groups. The experimental group received crowded environment-induced and cat odour stresses 4 weeks before spring insertion. On the 29th day in both groups, maxillary incisors were moved by the insertion of springs and exactly after 7 days, 9 rats from each group and after 14 days the remaining rats were sacrificed. Then the mesioincisal distance between maxillary incisors was measured. Afterwards, histological sections were prepared to count osteoclasts under a light microscope. The data on the extent of orthodontic tooth movement and the number of osteoclasts were analyzed by independent sample t-test. Results: The results indicated that on the 7th day after spring placement the orthodontic tooth movement was significantly higher in the control group compared to the experimental group (p<0.05). The number of osteoclasts at a significance level of α=0.1 in the control group was higher compared to the experimental group. On the 14th day after spring placement, the orthodontic tooth movement in the control group was significantly higher compared to the experimental group (p<0.05). However, there were no significant differences in the number of osteoclasts between the two groups. The rats experienced weight loss in the experimental group (p<0.05). Conclusions: Psychological stress led to a decrease in orthodontic tooth movement and in the number of osteoclasts around the root in the movement direction in rats, but a decrease in osteoclast counts was not parallel with time and demonstrated a nonlinear pattern. In addition, psychological stress led to weight loss in rats.

show abstract

Bone modeling: biomechanics, molecular mechanisms, and clinical perspectives

Cited by 160 publications

References 168 publications

Juveniles versus adults: differences in PGE2 levels in the gingival crevicular fluid during orthodontic tooth movement

Juveniles versus adults: differences in PGE2 levels in the gingival crevicular fluid during orthodontic tooth movement

Gingival Crevicular Fluid Turnover Markers in Premenopausal vs Postmenopausal Women receiving Orthodontic Treatment

Effect of psychological stress on orthodontic tooth movement in rats

Contact Info

Product

Resources

About