Bone mineral density surveillance for childhood, adolescent, and young adult cancer survivors: evidence-based recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group

Bone mineral density and nutrition in long-term survivors of childhood brain tumors

“…Drugs can also induce endocrine deficits [19,21]. CSI, a cornerstone in the treatment for MB and CNS-PNET, renders these patients even more vulnerable than other childhood cancer survivors to detrimental effects on the skeleton [22]. Cranial irradiation can damage the hypothalamicepituitary axis and reduce the production of hormones (growth hormone, sex steroids, insulin-like growth factors) imperative for developing the skeleton and muscle mass [23,24].…”

“…Cranial irradiation can damage the hypothalamicepituitary axis and reduce the production of hormones (growth hormone, sex steroids, insulin-like growth factors) imperative for developing the skeleton and muscle mass [23,24]. Hence, BMD surveillance for childhood cancer survivors is essential to prevent the negative consequences of fractures and is recommended for irradiated patients [22].…”

Generalizing approaches to surveillance for complex social outcomes in broad‐range patient populations—The cost in terms of lost information and subgroup utility

“…For instance, recommendations for breast cancer and ototoxicity surveillance in survivors who have received treatment in young adulthood up to the age of 30 years have been included, 6,7 and recommendations concerning other health outcomes complete the list of IGHG guidelines. [8][9][10][11][12][13][14][15][16][17] In this issue of Cancer on behalf of the IGHG, Devine et al 18 present an extensive review of studies (2009-2021) investigating childhood, adolescent, and young adult cancer survivors (CAYA-CSs) with respect to long-term education and employment adverse consequences (EEACs) along with suggestions for harmonized general guidelines for surveillance regarding these outcomes. Their report is aimed at presenting clinical practice guidelines (CPGs) for the surveillance of CAYA-CSs with recommendations and measures to prevent or compensate for adverse EEACs related to the initial cancer and the cancer treatment.…”

“…So far, the majority of these guidelines have concerned specific physical or medical health‐related outcomes, including fatigue. For instance, recommendations for breast cancer and ototoxicity surveillance in survivors who have received treatment in young adulthood up to the age of 30 years have been included, 6,7 and recommendations concerning other health outcomes complete the list of IGHG guidelines 8‐17 …”

A multidisciplinary approach to paediatric and adolescent metabolic health

“…In The Lancet Diabetes & Endocrinology, van Atteveld and colleagues, on behalf of the International Late Effects of Childhood Cancer Guideline Harmonization Group, provide harmonised recommendations for bone mineral density surveillance to facilitate earlier diagnosis, treatment, and follow-up of survivors with low or very low bone mineral density. 3 The authors also identify knowledge gaps for future research to focus on, with the goal of further improving bone mineral density surveillance and fracture prevention strategies in this vulnerable population.…”