Bone Mineral Density Screening and the Frequency of Osteopenia/Osteoporosis in Turkish Adult Patients With Celiac Disease

Sayar, Süleyman; Aykut, Hüseyin; Kaya, Özkan; Kürbüz, Kemal; Ak, Çağatay; Gökçen, Pınar; Bilgic, Nermin Mutlu; Adali, Güpse; Kahraman, Resul; Doganay, Levent; Özdil, Kamil

doi:10.5152/tjg.2021.20313

Cited by 8 publications

(3 citation statements)

References 28 publications

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“…Compared to matched controls, patients with celiac disease who underwent THA exhibited significantly higher rates of periprosthetic fractures at 2 years postoperatively. These results align with prior literature reporting on the negative impact of celiac disease on BMD and associated increased fragility fracture risk [ 10 , [13] , [14] , [15] , [16] ]. While BMD has been shown to significantly improve with treatment via GFDs, it has not been shown to normalize in all patients [ 9 , 13 , 15 , 16 ].…”

Section: Discussionsupporting

confidence: 91%

“…These results align with prior literature reporting on the negative impact of celiac disease on BMD and associated increased fragility fracture risk [ 10 , [13] , [14] , [15] , [16] ]. While BMD has been shown to significantly improve with treatment via GFDs, it has not been shown to normalize in all patients [ 9 , 13 , 15 , 16 ]. As a result, current guidelines recommend adult patients with celiac disease undergo routine screening with a dual-energy radiograph absorptiometry scan 1 year after the initiation of a GFD [ 17 ].…”

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

The Impact of Celiac Disease on Complication Rates After Total Joint Arthroplasty: A Matched Cohort Study

Cole¹,

Ross²,

Collins³

et al. 2022

Arthroplasty Today

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

The Impact of Celiac Disease on Complication Rates After Total Joint Arthroplasty: A Matched Cohort Study

Cole¹,

Ross²,

Collins³

et al. 2022

Arthroplasty Today

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“…Many studies indicate that patients with CD, including those with asymptomatic disease (21), have lower bone mineral density (BMD) compared to age-and sex-matched controls (22,23). The reported prevalence of osteopenia or osteoporosis in CD is variable, ranging from 38%-72% of newly diagnosed patients (Table 2) (24)(25)(26)(27). In a large cohort of patients with CD age 50 years and older, 44% had osteoporosis, indicating that this is a frequent and important issue for this population (28).…”

Section: Introductionmentioning

confidence: 99%

Celiac disease and bone

Kondapalli¹,

Walker²

2022

Archives of Endocrinology and Metabolism

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Celiac disease (CD) is an autoimmune disorder characterized by small intestinal inflammation triggered by gluten ingestion in genetically-predisposed individuals. A frequent extra-intestinal manifestation of CD is metabolic bone disease which contributes to an increased risk of fracture. The mechanisms underlying bone disease in CD remain incompletely understood, but multiple processes have been proposed including (1) malabsorption of calcium and vitamin D leading to secondary hyperparathyroidism and increased skeletal resorption, (2) pro-inflammatory cytokines altering the osteoprotegerin and receptor activator of nuclear kappa-B ligand ratio favoring osteoclastogenesis, (3) hypogonadism, and (4) low weight and malnutrition. Most studies show reduced bone mineral density in patients with CD. Bone microarchitecture is also deteriorated leading to reduced whole bone stiffness. Many, but not all investigations, have shown an increased risk of fracture associated with CD. The main stay of therapy for CD is maintaining a gluten-free diet. Improvement in bone mineral density with adherence to a gluten-free diet has been well-established. Bone mineral density remains lower, however, compared to controls and increased fracture risk can persist. There is no consensus on the timing of dual-energy x-ray absorptiometry for bone mineral density assessment in patients with CD. Routine screening for CD in patients with osteoporosis is not recommended. Little data are available on the use or efficacy of prescription osteoporosis therapeutics in patients with CD. Studies are needed to develop standardized guidelines for screening and treatment of metabolic bone disease in patients with CD to identify those who may need early intervention with prescription osteoporosis therapy.

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Osteoporosis and bone fractures in patients with celiac disease: A nationwide cohort study

Hansen,

Schwarz,

Rumessen

et al. 2023

Bone

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Bone Mineral Density Screening and the Frequency of Osteopenia/Osteoporosis in Turkish Adult Patients With Celiac Disease

Cited by 8 publications

References 28 publications

The Impact of Celiac Disease on Complication Rates After Total Joint Arthroplasty: A Matched Cohort Study

The Impact of Celiac Disease on Complication Rates After Total Joint Arthroplasty: A Matched Cohort Study

Celiac disease and bone

Osteoporosis and bone fractures in patients with celiac disease: A nationwide cohort study

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