Bone mineral density of total body, spine, and femoral neck in children and young adults: A cross-sectional and longitudinal study

Lu, P W; Briody, Julie; Ogle, Graham D; Morley, K.; Humphries, Ian R. J.; Allen, Jim; Howman‐Giles, Robert; Sillence, David; Cowell, Christopher T.

doi:10.1002/jbmr.5650090918

Cited by 279 publications

(83 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Tracking was inferred from the correlation between CHL and weight in early life and bone traits in adolescence because CHL or height predicts bone traits throughout childhood with similar strength. (29)(30)(31) Indeed, CHL at 6 months and height at 18 years equally predicted bone traits at 18 years. Thus we infer that the bone traits track as strongly as stature.…”

Section: Discussionmentioning

confidence: 92%

Familial resemblance and diversity in bone mass and strength in the population are established during the first year of postnatal life

Wang

Alén

Lyytikäinen

et al. 2010

Journal of Bone and Mineral Research

View full text Add to dashboard Cite

Familial resemblance and diversity in bone structure and strength in adulthood are determined in part during growth. Whether these characteristics are established during gestation or shortly after birth is not known. Total-body, lumbar spine, and femoral neck size and mass and indices of tibial bending strength and distal radial compressive strength were measured using bone densitometry and quantitative computed tomography in 236 girls at 18.5 years of age. Among them, 219, 141, and 105 girls had crown-heel length (CHL) and weight recorded at birth and at 6 and 12 months of age, and then height and weight were recorded at 3, 5, 10, 13, and 15 years of age in 181, 176, 127, 111, and 228 girls, respectively. Of these girls, 101 and 93 girls also had bone structure assessed at 11 and 13 years of age, respectively. Similar bone measurements were made once in 78 mother-father pairs. CHL and weight at birth did not correlate or did so weakly with bone traits in girls at 18 years of age. By contrast, CHL at 6 months correlated with the height, bone traits, and strength at puberty and at 18 years of age (r ¼ 0.24-0.56, p < .001) in girls and with their parents' height and bone traits (r ¼ 0.15-0.37, p < .05). When the girls' CHL at 6 months was stratified into quartiles, the absolute and relative differences in bone traits observed at puberty ($11.5 years) were maintained as these traits tracked during the ensuing 7 years. Similarly, weight at 6 months correlated with the girls' bone traits at puberty and 18 years of age (r ¼ 0.22-0.55, p < .05). During puberty and at 18 years of age, the girls' bone traits correlated with the corresponding traits in their parents (r ¼ 0.32-0.43, p < .01). It is concluded that familial resemblance in bone structural strength and the position of an individual's bone traits relative to others in adulthood are likely to be established during the first year of life. Thus susceptibility to bone fragility late in life has its antecedents established early in life. ß

show abstract

Section: Discussionmentioning

confidence: 92%

Familial resemblance and diversity in bone mass and strength in the population are established during the first year of postnatal life

Wang

Alén

Lyytikäinen

et al. 2010

Journal of Bone and Mineral Research

View full text Add to dashboard Cite

show abstract

“…Measured over an extended period of time (usually Ͼ1 yr), bone mineral content measures long-term calcium balance. Bone mineral content increases throughout childhood (8), peaks in adolescence (9), remains relatively constant in early/late adulthood (10), and declines in old age (Normal Population Data Base, DPX-IQ Reference Manual, Documentation Version 5/96; Lunar Corporation, Madison, WI).…”

Section: Calcium Distributionmentioning

confidence: 99%

Calcium Metabolism in Health and Disease

Peacock

2010

Clinical Journal of the American Society of Nephrology

648

502

View full text Add to dashboard Cite

This brief review focuses on calcium balance and homeostasis and their relationship to dietary calcium intake and calcium supplementation in healthy subjects and patients with chronic kidney disease and mineral bone disorders (CKD-MBD). Calcium balance refers to the state of the calcium body stores, primarily in bone, which are largely a function of dietary intake, intestinal absorption, renal excretion, and bone remodeling. Bone calcium balance can be positive, neutral, or negative, depending on a number of factors, including growth, aging, and acquired or inherited disorders. Calcium homeostasis refers to the hormonal regulation of serum ionized calcium by parathyroid hormone, 1,25-dihydroxyvitamin D, and serum ionized calcium itself, which together regulate calcium transport at the gut, kidney, and bone. Hypercalcemia and hypocalcemia indicate serious disruption of calcium homeostasis but do not reflect calcium balance on their own. Calcium balance studies have determined the dietary and supplemental calcium requirements needed to optimize bone mass in healthy subjects. However, similar studies are needed in CKD-MBD, which disrupts both calcium balance and homeostasis, because these data in healthy subjects may not be generalizable to this patient group. Importantly, increasing evidence suggests that calcium supplementation may enhance soft tissue calcification and cardiovascular disease in CKD-MBD. Further research is needed to elucidate the risks and mechanisms of soft tissue calcification with calcium supplementation in both healthy subjects and CKD-MBD patients.

show abstract

“…Childhood bone development is extremely important and is influenced by diet and nutrition 30) . Any disturbances in growth patterns could predispose children to bony defects, low BMD, high bone turnover or high risk of osteoporotic fracture [31][32][33] .…”

Section: Discussionmentioning

confidence: 99%

Mandibular Cortical Width on Panoramic Images of Children in the Lao People’s Democratic Republic

Vongsa

Aboshi

Ejima

et al. 2018

J. Hard Tissue Biology.

View full text Add to dashboard Cite

The purpose of this study was to determine correlations between height and weight with mandibular cortical width (MCW) that may aid identifi cation of bone mineral density (BMD) in a pediatric population. A total of 122 patients (69 boys and 53 girls) aged 4 to 6 years old who were patients at the Dental Hospital of Faculty of Dentistry (UHS, Lao P.D.R.) participated in the study. Anthropometric data of height and weight were recorded. Digital panoramic radiographs were taken and transferred to Nihon University, Tokyo via telemedicine system. MCW was measured using a SDS-DICOM viewer application. The Mann-Whitney U test was performed to analyze MCW gender diff erences. Tukey -Kramer method was performed to determine means of MCW, Height, Weight between each age group. The Pearson's correlation test was performed to analyze the correlation between MCW and Height or Weight. P values less than 0.05 were considered statistically significant. The range of MCW were between 1.40-3.03 mm in males and 1.68-2.80 mm in females, with no sexual diff erences. As age increased, each parameter (MCW, Height, Weight) increased, but no signifi cant diff erence between age groups was detected in MCW. There were positive signifi cant correlations between height and MCW, but not between weight and MCW. This pilot study has shown that MCW does not appear to be a useful indicator for the diagnosis of hidden children osteogenesis. Further studies are needed to examine if other panoramic radiomorphometric indices could be more relevant.

show abstract

Bone mineral density of total body, spine, and femoral neck in children and young adults: A cross-sectional and longitudinal study

Cited by 279 publications

References 16 publications

Familial resemblance and diversity in bone mass and strength in the population are established during the first year of postnatal life

Familial resemblance and diversity in bone mass and strength in the population are established during the first year of postnatal life

Calcium Metabolism in Health and Disease

Mandibular Cortical Width on Panoramic Images of Children in the Lao People’s Democratic Republic

Contact Info

Product

Resources

About