Bone Mineral Density of the Lumbar Spine in Children and Adolescents With Celiac Disease on a Gluten-Free Diet in São Paulo, Brazil

Sdepanian, Vera Lúcia; Carvalho, Cecília Noronha de Miranda; Morais, Mauro Batista de; Colugnati, Fernando Antônio Basile; Fagundes-Neto, Ulysses

doi:10.1097/00005176-200311000-00013

Cited by 39 publications

(33 citation statements)

References 35 publications

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“…Children with CD have a lower bone mass at diagnosis compared with healthy controls and have revealed complete recovery or significant improvement of BMD following diet therapy (11)(12)(13)(14). In this study, we also observed a lower BMD in celiac patients compared with the healthy subjects.…”

Section: Discussionsupporting

confidence: 68%

Bone mineral density and vitamin K status in children with celiac disease: Is there a relation?

Volkan¹,

Fettah²,

İşlek³

et al. 2018

Turk J Gastroenterol

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Section: Discussionsupporting

confidence: 68%

Bone mineral density and vitamin K status in children with celiac disease: Is there a relation?

Volkan¹,

Fettah²,

İşlek³

et al. 2018

Turk J Gastroenterol

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“…It has been suggested that patients with a shorter symptomatic period, recover more completely than those suffering longer periods of untreated CD (Scotta et al, 1997). Sdepanian et al (2003) found that BMD was significantly lower in adolescent with CD on GFD compared with controls but not in children with CD compared with controls; the authors attributed these findings to the longer time between symptoms and diagnosis in adolescents, due to which they suffer more malnutrition and more bone damage than children. In our study, children older than 4 years of age compared with young children suffered a longer period between symptoms and diagnosis.…”

Section: Discussionmentioning

confidence: 97%

Bone mineral density in children with celiac disease. Effect of a Gluten-free diet

Tau

Mautalén²,

Rosa

et al. 2005

Eur J Clin Nutr

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Objective: To assess the degree of osteopenia in children with celiac disease (CD) at the time of diagnosis and the effect of a gluten-free diet (GFD). Design: Longitudinal and prospective study. Subjets: In total, 24 children (18 girls, six boys) diagnosed with CD by means of an intestinal biopsy were included in the study. Mean7s.d. age was 4.974.3 years. In all, 16 patients were under (2.2070.82 year) and eight were over the age of 4 years (10.3072.90 year). The time between the first symptoms and diagnosis was 17.30724.70 months (range: 2-109 months). Spine bone mineral content (BMC), area and bone mineral density (BMD) were measured by DXA at baseline and 1.1770.93 years after GFD. Results: Before treatment, mean7s.d. BMD was 0.4670.13 g/cm 2 , the BMD Z-score was À1.3671.20, and was below À1 s.d. in 14 patients (58%). BMC, area and BMD increased significantly on GFD. BMD increased from 0.4670.13 to 0.5570.13 g/cm 2 (Po0.001). BMD Z-score improved from À1.3671.20 to À0.2371.20 after GFD. However, BMD increased more than 1 s.d. in 15 of the 16 children under the age of 4 years, a similar increase was only observed in four of the eight children aged more than 4 years, some of whom did not follow GFD strictly. Height and weight increased significantly with GFD (Po0.001) and the increase correlated positively with the increase in BMD. Conclusions: Axial BMD below À1 s.d. was found in 58% of children with celiac disease. Axial bone mass reverted to normal values in most children under the age of 4, who had low bone mass, all of whom followed GFD strictly.

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“…In São Paulo, Brazil, SDEPANIAN et al (58) , in 13 adolescents with CD reported that BMD was lower than that of the controls. Furthemore, the proportion of adolescents who had started a GFD after 2 years of age was higher than that of children with CD, an experience similar to ours.…”

Section: Bone Diseasementioning

confidence: 95%

Celiac disease in Brazilian patients: associations, complications and causes of death. Forty years of clinical experience

Kotze

2009

Arq. Gastroenterol.

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-Context -Celiac disease is a multisystem auto-immune disorder and may start at any age in genetically predisposed individuals. Objective -To identify associations, complications, and cause of death in Brazilian patients. Methods -One hundred and fifty-seven patients were studied: 23 adolescents and 134 adults, 79.6% females, 20.4% males, 75.8% at the time of diagnosis and 24.2% on a gluten-free diet, follow-up between 1 and 40 years. The diagnosis of celiac disease was based on histologic findings and the presence of serologic auto-antibodies markers for celiac disease. Specific tests were done according to clinical suspicion of associations. Bone mineral density was determined by dual energy x-rays in 53 patients upon diagnosis. The data regarding associations, complications, and causes of death were obtained by interviews and from the patient's charts. -Results -Associations: atopy (22.3%), depression (17.2%), thyroid disorder (15.9%), dermatitis herpetiformis (11.5%), diabetes mellitus types 1 and 2 (4.5%) and tumors (4.5%). Complications -Anemia and osteopenia/osteoporosis in all groups; increased number of spontaneous abortion. Four patients (4.5%) died (one from lymphoma, one with diabetes type 1, one from acute meningitis and one due to suicide). Conclusions -This experience is similar to those described in the world literature. Celiac disease presents the same characteristics independently of the geographic region. We recommend periodic evaluations, from childhood, independent of the duration of the diet. The key is to establish an interval between evaluations. HEADINGS -Celiac disease. Gluten. Lymphoma, non-Hodgkin.

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Bone Mineral Density of the Lumbar Spine in Children and Adolescents With Celiac Disease on a Gluten-Free Diet in São Paulo, Brazil

Abstract: The BMD of adolescents with CD was lower than that of the control subjects, whereas no difference was found between the BMD of children with CD and that of control subjects.

Cited by 39 publications

References 35 publications

Bone mineral density and vitamin K status in children with celiac disease: Is there a relation?

Bone mineral density and vitamin K status in children with celiac disease: Is there a relation?

Bone mineral density in children with celiac disease. Effect of a Gluten-free diet

Celiac disease in Brazilian patients: associations, complications and causes of death. Forty years of clinical experience

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